Eliza Cox Akin and Mary Graham Charles were the wives and partners to two of the most important American caricaturists of the nineteenth-century, James Akin and William Charles. Surviving engravings and historical ephemera reveal that these women contributed to their husbands’ engraving businesses and that Eliza participated in engraving prints. In order to establish an appreciation of the role women played in the early American printmaking world, this chapter examines the lives of Eliza Cox Akin and Mary Graham Charles and considers their position in producing, and within the market for, engravings in the United States during the late 1790s and early 1800s.