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Eslicarbazepine Acetate

Published online by Cambridge University Press:  01 June 2018

Philip N. Patsalos  and
Erik K. St Louis
Philip N. Patsalos
Affiliation:
UCL Institute for Neurology
Erik K. St Louis
Affiliation:
Mayo Clinic
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The Epilepsy Prescriber's Guide to Antiepileptic Drugs , pp. 71 - 80
Publisher: Cambridge University Press
Print publication year: 2018

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References

Suggested Reading

Almeida, L, Falcao, A, Maia, J, Mazur, D, Gellert, M, Soares-da-Silva, P. Single-dose and steady-state pharmacokinetics of eslicarbazepine acetate (BIA 2–093) in healthy elderly and young subjects. Journal of Clinical Pharmacology 2005; 45: 1062–1066.Google Scholar
Almeida, L, Potgieter, JH, Maia, J, Potgieter, MA, Moto, F, Soares-da-Silva, P. Pharmacokinetics of eslicarbazepine acetate in patients with moderate hepatic impairment. European Journal of Clinical Pharmacology 2008; 64: 267–273.CrossRefGoogle ScholarPubMed
Almeida, L, Soares-da-Silva, P. Eslicarbazepine acetate (BIA-2–093). Neurotherapeutics 2007; 4: 88–96.CrossRefGoogle ScholarPubMed
Elger, C, Halasz, P, Maia, J, Almeida, L, Soares-da-Silva, P, on behalf of the BIA-2093–301 Investigators Study Group. Efficacy and safety of eslicarbazepine acetate as adjunctive treatment in adults with refractory partial-onset seizures: a randomized, double-blind, placebo controlled, parallel-group phase III study. Epilepsia 2009; 50: 454–463.CrossRefGoogle ScholarPubMed
Falcão, A, Fuseau, E, Nunes, T, Almeida, L, Soares-da-Silva, P. Pharmacokinetics, drug interactions and exposure-response relationship of eslicarbazepine acetate in adult patients with partial-onset seizures: population pharmacokinetic and pharmacokinetic/pharmacody-namic analyses. CNS Drugs 2012; 26: 79–91.CrossRefGoogle Scholar
Gil-Nagel, A, Elger, C, Ben-Menachem, E, Halász, P, Lopes-Lima, J, Gabbai, AA, Nunes, T, Falcão, A, Almeida, L, da-Silva, PS. Efficacy and safety of eslicarbazepine acetate as add-on treatment in patients with focal-onset seizures: integrated analysis of pooled data from double-blind phase III clinical studies. Epilepsia 2013; 54: 98–107.CrossRefGoogle ScholarPubMed
Gil-Nagel, A, Lopes-Lima, J, Almeida, L, Maia, J, Soares-da-Silva, P, on behalf of the BIA-2093–303 Investigators Study Group. Efficacy and safety of 800 and 1200 mg eslicarbazepine acetate as adjunctive treatment in adults with refractory partial-onset seizures. Acta Neurologica Scandinavica 2009; 120: 281–287.CrossRefGoogle ScholarPubMed
Johannessen Landmark, C, Patsalos, PN. Drug interactions involving the new second- and third-generation antiepileptic drugs. Expert Reviews in Neurotherapeutics 2010; 10: 119–140.CrossRefGoogle ScholarPubMed
Meis, J, Almeida, L, Falcao, A, Soares, E, Mota, F, Potgieter, MA, Potgieter, JH, Soares-da-Silva, P. Effect of renal impairment on the pharmacokinetics of eslicarbazepine acetate. International Journal of Clinical Pharmacology and Therapeutics 2008; 463: 119–130.Google Scholar
Nunes, T, Rocha, JF, Falcão, A, Almeida, L, Soares-da-Silva, P. Steady-state plasma and cerebrospinal fluid pharmacokinetics and tolerability of eslicarbazepine acetate and oxcarbazepine in healthy volunteers. Epilepsia 2013; 54: 108–116.CrossRefGoogle ScholarPubMed
Patsalos, PN. Antiepileptic drug interactions: a clinical guide, 3rd edition. Springer, London, UK; 2016.Google Scholar
Patsalos, PN, Berry, DJ. Pharmacotherapy of the third-generation AEDs: lacosamide, retigabine and eslicarbazepine acetate. Expert Opinion in Pharmacotherapy 2012; 13:699–715.CrossRefGoogle ScholarPubMed
Perucca, E, Elger, C, Halász, P, Falcão, A, Almeida, L, Soares-da-Silva, P. Pharmacokinetics of eslicarbazepine acetate at steady-state in adults with partial-onset seizures. Epilepsy Research 2011; 96: 132–1329.CrossRefGoogle ScholarPubMed
Villanueva, V, Bermejo, P, Montoya, J, Toledo, M, Gómez-Ibáñez, A, Garcés, M, Vilella, L, López-González, FJ, Rodriguez-Osorio, X, Campos, D, Martínez, P, Giner, P, Zurita, J, Rodríguez-Uranga, J, Ojeda, J, Mauri, JA, Camacho, JL, Ruiz-Giménez, J, Poza, JJ, Massot-Tarrús, A, Galiano, ML, Bonet, M. EARLY-ESLI study: long-term experience with eslicarbazepine acetate after first monotherapy failure. Acta Neurologica Scandinavica 2017; 136: 254–264.Google Scholar

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