Skip to main content Accessibility help
×
×
Home
  • Print publication year: 2014
  • Online publication date: October 2014

Chapter 32 - Epigenetics

from Section 5 - Research: Mediators and Moderators
Recommend this book

Email your librarian or administrator to recommend adding this book to your organisation's collection.

A Concise Guide to Understanding Suicide
  • Online ISBN: 9781139519502
  • Book DOI: https://doi.org/10.1017/CBO9781139519502
Please enter your name
Please enter a valid email address
Who would you like to send this to *
×

References

Agid, O., Shapira, B., Zislin, J., et al. (1999). Environment and vulnerability to major psychiatric illness: a case control study of early parental loss in major depression, bipolar disorder and schizophrenia. Molecular Psychiatry, 4, 163–172.
Aguilera, G., Kiss, A., Liu, Y., & Kamitakahara, A. (2007). Negative regulation of corticotropin-releasing factor expression and limitation of stress response. Stress, 10, 153–161.
Aid, T., Kazantseva, A., Piirsoo, M., Palm, K., & Timmusk, T. (2007). Mouse and rat BDNF gene structure and expression revisited. Journal of Neuroscience Research, 85, 525–535.
Alt, S. R., Turner, J. D., Klok, M. D., et al. (2010). Differential expression of glucocorticoid receptor transcripts in major depressive disorder is not epigenetically programmed. Psychoneuroendocrinology, 35, 544–556.
Andersen, S. L., Tomada, A., Vincow, E. S., et al. (2008). Preliminary evidence for sensitive periods in the effect of childhood sexual abuse on regional brain development. Journal of Neuropsychiatry and Clinical Neuroscience, 20, 292–301.
Aston, C., Jiang, L., & Sokolov, B. P. (2005). Transcriptional profiling reveals evidence for signaling and oligodendroglial abnormalities in the temporal cortex from patients with major depressive disorder. Molecular Psychiatry, 10, 309–322.
Bannister, A. J., Zegerman, P., Partridge, J. F., et al. (2001). Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature, 410, 120–124.
Barrera, L. O., Li, Z., Smith, A. D., et al. (2008). Genome-wide mapping and analysis of active promoters in mouse embryonic stem cells and adult organs. Genome Research, 18, 46–59.
Barski, A., Cuddapah, S., Cui, K., et al. (2007). High-resolution profiling of histone methylations in the human genome. Cell, 129, 823–837.
Bensley, L. S., Van Eenwyk, J., Spieker, S. J., & Schoder, J. (1999). Self-reported abuse history and adolescent problem behaviors. I. Antisocial and suicidal behaviors. Journal of Adolescent Health, 24, 163–172.
Bhagwagar, Z. & Cowen, P. J. (2008). ‘It’s not over when it’s over’: persistent neurobiological abnormalities in recovered depressed patients. Psychological Medicine, 38, 307–313.
Botuyan, M. V., Lee, J., Ward, I. M., et al. (2006). Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell, 127, 1361–1373.
Bremner, J. D., Randall, P., Vermetten, E., et al. (1997). Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse – a preliminary report. Biological Psychiatry, 41, 23–32.
Bremner, J. D., Vythilingam, M., Vermetten, E., et al. (2003). MRI and PET study of deficits in hippocampal structure and function in women with childhood sexual abuse and posttraumatic stress disorder. American Journal of Psychiatry, 160, 924–932.
Briere, J., & Elliott, D. M. (2003). Prevalence and psychological sequelae of self-reported childhood physical and sexual abuse in a general population sample of men and women. Child Abuse and Neglect, 27, 1205–1222.
Brown, G. W., & Moran, P. (1994). Clinical and psychosocial origins of chronic depressive episodes. I: A community survey. British Journal of Psychiatry, 165, 447–456.
Brunoni, A. R., Lopes, M., & Fregni, F. (2008). A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression. International Journal of Neuropsychopharmacology, 11, 1169–1180.
Carpenter, L. L., Tyrka, A. R., McDougle, C. J., et al. (2004). Cerebrospinal fluid corticotropin-releasing factor and perceived early life stress in depressed patients and healthy control subjects. Neuropsychopharmacology, 29, 777–784.
Carrion, V. G., Weems, C. F., Eliez, S., et al. (2001). Attenuation of frontal asymmetry in pediatric posttraumatic stress disorder. Biological Psychiatry, 50, 943–951.
Chan, J. P., Unger, T. J., Byrnes, J., & Rios, M. (2006). Examination of behavioral deficits triggered by targeting Bdnf in fetal or postnatal brains of mice. Neuroscience, 142, 49–58.
Chen, B., Dowlatshahi, D., MacQueen, G. M., Wang, J. F., & Young, L. T. (2001). Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication. Biological Psychiatry, 50, 260–265.
Chen, E. S., Ernst, C., & Turecki, G. (2011). The epigenetic effects of antidepressant treatment on human prefrontal cortex BDNF expression. International Journal of Neuropsychopharmacology, 14, 427–429.
Chen, W. G., Chang, Q., Lin, Y., et al. (2003). Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science, 302, 885–889.
Children’s Bureau. (2010). Child maltreatment 2009. In US Department of Health and Human Services, A. O. C., Youth and Families (Ed.). Washington DC: Government Printing Office.
Clements, A., Poux, A. N., Lo, W. S., et al. (2003). Structural basis for histone and phosphohistone binding by the GCN5 histone acetyltransferase. Molecular Cell, 12, 461–473.
Cronholm, B., Asberg, M., Montgomery, S., & Schalling, D. (1977). Suicidal behaviour syndrome with low CSF 5-HIAA. British Medical Journal, 1, 776.
De Bellis, M. D., Keshavan, M. S., Frustaci, K., et al. (2002). Superior temporal gyrus volumes in maltreated children and adolescents with PTSD. Biological Psychiatry, 51, 544–552.
De Luca, V., Likhodi, O., Kennedy, J. L., & Wong, A. H. (2007). Differential expression and parent-of-origin effect of the 5-HT2A receptor gene C102T polymorphism: analysis of suicidality in schizophrenia and bipolar disorder. American Journal of Medical Genetics B Neuropsychiatric Genetics, 144B, 370–374.
De Luca, V., Viggiano, E., Dhoot, R., Kennedy, J. L., & Wong, A. H. (2009). Methylation and QTDT analysis of the 5-HT2A receptor 102C allele: analysis of suicidality in major psychosis. Journal of Psychiatric Research, 43, 532–537.
Deaton, A. M., Webb, S., Kerr, A. R., et al. (2011). Cell type-specific DNA methylation at intragenic CpG islands in the immune system. Genome Research, 21, 1074–1086.
Dinwiddie, S., Heath, A. C., Dunne, M. P., et al. (2000). Early sexual abuse and lifetime psychopathology: a co-twin-control study. Psychological Medicine, 30, 41–52.
Driessen, M., Herrmann, J., Stahl, K., et al. (2000). Magnetic resonance imaging volumes of the hippocampus and the amygdala in women with borderline personality disorder and early traumatization. Archives of General Psychiatry, 57, 1115–1122.
Du, L., Bakish, D., Lapierre, Y. D., Ravindran, A. V., & Hrdina, P. D. (2000). Association of polymorphism of serotonin 2A receptor gene with suicidal ideation in major depressive disorder. American Journal of Medical Genetics, 96, 56–60.
Du, L., Faludi, G., Palkovits, M., Bakish, D., & Hrdina, P. D. (2001). Serotonergic genes and suicidality. Crisis, 22, 54–60.
Duman, R. S., & Monteggia, L. M. (2006). A neurotrophic model for stress-related mood disorders. Biological Psychiatry, 59, 1116–1127.
Duric, V., & McCarson, K. E. (2005). Hippocampal neurokinin-1 receptor and brain-derived neurotrophic factor gene expression is decreased in rat models of pain and stress. Neuroscience, 133, 999–1006.
Duric, V., & McCarson, K. E. (2006). Effects of analgesic or antidepressant drugs on pain- or stress-evoked hippocampal and spinal neurokinin-1 receptor and brain-derived neurotrophic factor gene expression in the rat. Journal of Pharmacology and Experimental Therapeutics, 319, 1235–1243.
Dwivedi, Y., Rizavi, H. S., Conley, R. R., et al. (2003). Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects. Archives of General Psychiatry, 60, 804–815.
Dwivedi, Y., Rizavi, H. S., Zhang, H., et al. (2009). Neurotrophin receptor activation and expression in human postmortem brain: effect of suicide. Biological Psychiatry, 65, 319–328.
Elliott, E., Ezra-Nevo, G., Regev, L., Neufeld-Cohen, A., & Chen, A. (2010). Resilience to social stress coincides with functional DNA methylation of the Crf gene in adult mice. Nature Neuroscience, 13, 1351–1353.
Ernst, C., Chen, E. S., & Turecki, G. (2009a). Histone methylation and decreased expression of TrkB.T1 in orbital frontal cortex of suicide completers. Molecular Psychiatry, 14, 830–832.
Ernst, C., Deleva, V., Deng, X., et al. (2009b). Alternative splicing, methylation state, and expression profile of tropomyosin-related kinase B in the frontal cortex of suicide completers. Archives of General Psychiatry, 66, 22–32.
Evans, E., Hawton, K., & Rodham, K. (2005). Suicidal phenomena and abuse in adolescents: a review of epidemiological studies. Child Abuse and Neglect, 29, 45–58.
Fergusson, D. M., Horwood, L. J., & Lynskey, M. T. (1996). Childhood sexual abuse and psychiatric disorder in young adulthood: II. Psychiatric outcomes of childhood sexual abuse. Journal of the American Academy of Child and Adolescent Psychiatry, 35, 1365–74.
Fiori, L. M., & Turecki, G. (2008). Implication of the polyamine system in mental disorders. Journal of Psychiatry and Neuroscience, 33, 102–110.
Fischle, W., Tseng, B. S., Dormann, H. L., et al. (2005). Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation. Nature, 438, 1116–1122.
Francis, D., Diorio, J., Liu, D., & Meaney, M. J. (1999). Nongenomic transmission across generations of maternal behavior and stress responses in the rat. Science, 286, 1155–1158.
Gainer, H., Fields, R. L., & House, S. B. (2001). Vasopressin gene expression: experimental models and strategies. Experimental Neurology, 171, 190–199.
Gilad, G. M., & Gilad, V. H. (2003). Overview of the brain polyamine-stress-response: regulation, development, and modulation by lithium and role in cell survival. Cellular and Molecular Neurobiology, 23, 637–649.
Gilad, G. M., Gilad, V. H., Eliyayev, Y., & Rabey, J. M. (1998). Developmental regulation of the brain polyamine-stress-response. International Journal of Developmental Neuroscience, 16, 271–8.
Gladstone, G. L., Parker, G. B., Mitchell, P. B., et al. (2004). Implications of childhood trauma for depressed women: an analysis of pathways from childhood sexual abuse to deliberate self-harm and revictimization. American Journal of Psychiatry, 161, 1417–1425.
Gorey, K. M., & Leslie, D. R. (1997). The prevalence of child sexual abuse: integrative review adjustment for potential response and measurement biases. Child Abuse and Neglect, 21, 391–398.
Grayson, D. R., Jia, X., Chen, Y., et al. (2005). Reelin promoter hypermethylation in schizophrenia. Proceedings of the National Academy of Sciences USA, 102, 9341–9346.
Gronli, J., Bramham, C., Murison, R., et al. (2006). Chronic mild stress inhibits BDNF protein expression and CREB activation in the dentate gyrus but not in the hippocampus proper. Pharmacology, Biochemistry and Behavior, 85, 842–849.
Gross, J. A., Fiori, L. M., Labonté, B., Lopez, J. P., & Turecki, G. (2012). Effects of promoter methylation on increased expression of polyamine biosynthetic genes in suicide. Journal of Psychiatric Research, 47(4), 513–519.
Guidotti, A., Auta, J., Davis, J. M., et al. (2000). Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study. Archives of General Psychiatry, 57, 1061–1069.
Hata, K., Okano, M., Lei, H., & Li, E. (2002). Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. Development, 129, 1983–1993.
He, L., & Hannon, G. J. (2004). MicroRNAs: small RNAs with a big role in gene regulation. Nature Reviews Genetics, 5, 522–531.
Heckers, S., Stone, D., Walsh, J., et al. (2002). Differential hippocampal expression of glutamic acid decarboxylase 65 and 67 messenger RNA in bipolar disorder and schizophrenia. Archives of General Psychiatry, 59, 521–529.
Heim, C., & Nemeroff, C. B. (2001). The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies. Biological Psychiatry, 49, 1023–1039.
Heim, C., Newport, D. J., Heit, S., et al. (2000). Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood. JAMA, 284, 592–597.
Heim, C., Mletzko, T., Purselle, D., Musselman, D. L., & Nemeroff, C. B. (2008a). The dexamethasone/corticotropin-releasing factor test in men with major depression: role of childhood trauma. Biological Psychiatry, 63, 398–405.
Heim, C., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2008b). The link between childhood trauma and depression: insights from HPA axis studies in humans. Psychoneuroendocrinology, 33, 693–710.
Heim, C., Young, L. J., Newport, D. J., et al. (2009). Lower CSF oxytocin concentrations in women with a history of childhood abuse. Molecular Psychiatry, 14, 954–958.
Heim, C., Shugart, M., Craighead, W. E., & Nemeroff, C. B. (2010). Neurobiological and psychiatric consequences of child abuse and neglect. Developmental Psychobiology, 52, 671–90.
Ito, S., D’Alessio, A. C., Taranova, O. V., et al. (2010). Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature, 466, 1129–1133.
Iwamoto, K., Bundo, M., Ueda, J., et al. (2011). Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons. Genome Research, 21, 688–696.
Jaffee, S. R., Moffitt, T. E., Caspi, A., et al. (2002). Differences in early childhood risk factors for juvenile-onset and adult-onset depression. Archives of General Psychiatry, 59, 215–222.
Kaplan, M. J., & Klinetob, N. A. (2000). Childhood emotional trauma and chronic posttraumatic stress disorder in adult outpatients with treatment-resistant depression. Journal of Nervous and Mental Disease, 188, 596–601.
Keller, S., Sarchiapone, M., Zarrilli, F., et al. (2010). Increased BDNF promoter methylation in the Wernicke area of suicide subjects. Archives of General Psychiatry, 67, 258–267.
Kendler, K. S., Bulik, C. M., Silberg, J., et al. (2000). Childhood sexual abuse and adult psychiatric and substance use disorders in women: an epidemiological and cotwin control analysis. Archives of General Psychiatry, 57, 953–959.
Kendler, K. S., Kuhn, J. W., & Prescott, C. A. (2004). Childhood sexual abuse, stressful life events and risk for major depression in women. Psychological Medicine, 34, 1475–1482.
Kim, Y. K., Lee, H. P., Won, S. D., et al. (2007). Low plasma BDNF is associated with suicidal behavior in major depression. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 31, 78–85.
Kirmizis, A., Santos-Rosa, H., Penkett, C. J., et al. (2007). Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation. Nature, 449, 928–932.
Klempan, T. A., Sequeira, A., Canetti, L., et al. (2009). Altered expression of genes involved in ATP biosynthesis and GABAergic neurotransmission in the ventral prefrontal cortex of suicides with and without major depression. Molecular Psychiatry, 14, 175–189.
Klose, R. J., & Bird, A. P. (2006). Genomic DNA methylation: the mark and its mediators. Trends in Biochemical Sciences, 31, 89–97.
Kouzarides, T. (2007). Chromatin modifications and their function. Cell, 128, 693–705.
Kriaucionis, S., & Heintz, N. (2009). The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science, 324, 929–930.
Kundakovic, M., Chen, Y., Costa, E., & Grayson, D. R. (2007). DNA methyltransferase inhibitors coordinately induce expression of the human reelin and glutamic acid decarboxylase 67 genes. Molecular Pharmacology, 71, 644–653.
Labonté, B., Suderman, M., Maussion, G., et al. (2012a). Genome-wide epigenetic regulation by early life trauma. Archives of General Psychiatry, 69, 722–731.
Labonté, B., Yerko, V., Gross, J., et al. (2012b). Differential glucocorticoid receptor exon 1(B), 1(C), and 1(H) expression and methylation in suicide completers with a history of childhood abuse. Biological Psychiatry, 72, 41–48.
Labonté, B., Suderman, M., Maussion, G., et al. (2013). Genome-wide methylation changes in the suicide brain. American Journal of Psychiatry, 170, 511–520.
Ladd-Acosta, C., Pevsner, J., Sabunciyan, S., et al. (2007). DNA methylation signatures within the human brain. American Journal of Human Genetics, 81, 1304–1315.
Lan, F., Bayliss, P. E., Rinn, J. L., et al. (2007). A histone H3 lysine 27 demethylase regulates animal posterior development. Nature, 449, 689–694.
Laplante, P., Diorio, J. & Meaney, M. J. (2002). Serotonin regulates hippocampal glucocorticoid receptor expression via a 5-HT7 receptor. Brain Research: Developmental Brain Research, 139, 199–203.
Liu, D., Diorio, J., Tannenbaum, B., et al. (1997). Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress. Science, 277, 1659–1662.
Lopez, J. P., Mamdani, F., Labonté, B., et al. (2013). Epigenetic regulation of BDNF expression according to antidepressant response. Molecular Psychiatry, 18, 398–399.
Matrisciano, F., Bonaccorso, S., Ricciardi, A., et al. (2009). Changes in BDNF serum levels in patients with major depression disorder (MDD) after 6 months treatment with sertraline, escitalopram, or venlafaxine. Journal of Psychiatric Research, 43, 247–254.
Maunakea, A. K., Nagarajan, R. P., Bilenky, M., et al. (2010). Conserved role of intragenic DNA methylation in regulating alternative promoters. Nature, 466, 253–257.
McCauley, J., Kern, D. E., Kolodner, K., et al. (1997). Clinical characteristics of women with a history of childhood abuse: unhealed wounds. JAMA, 277, 1362–1368.
McCormick, J. A., Lyons, V., Jacobson, M. D., et al. (2000). 5’-heterogeneity of glucocorticoid receptor messenger RNA is tissue specific: differential regulation of variant transcripts by early life events. Molecular Endocrinology, 14, 506–517.
McGowan, P. O., Sasaki, A., Huang, T. C., et al. (2008). Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain. PLoS One, 3, e2085.
McGowan, P. O., Sasaki, A., D’Alessio, A. C., et al. (2009). Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nature Neuroscience, 12, 342–348.
McGowan, P. O., Suderman, M., Sasaki, A., et al. (2011). Broad epigenetic signature of maternal care in the brain of adult rats. PLoS One, 6, e14739.
Meaney, M. J. (2001). Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. Annual Review of Neuroscience, 24, 1161–1192.
Meaney, M. J., Aitken, D. H. & Sapolsky, R. M. (1987). Thyroid hormones influence the development of hippocampal glucocorticoid receptors in the rat: a mechanism for the effects of postnatal handling on the development of the adrenocortical stress response. Neuroendocrinology, 45, 278–283.
Meaney, M. J., Diorio, J., Francis, D., et al. (2000). Postnatal handling increases the expression of cAMP-inducible transcription factors in the rat hippocampus: the effects of thyroid hormones and serotonin. Journal of Neuroscience, 20, 3926–3935.
Mellen, M., Ayata, P., Dewell, S., Kriaucionis, S., & Heintz, N. (2012). MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system. Cell, 151, 1417–1430.
Merali, Z., Du, L., Hrdina, P., et al. (2004). Dysregulation in the suicide brain: mRNA expression of corticotropin-releasing hormone receptors and GABA(A) receptor subunits in frontal cortical brain region. Journal of Neuroscience, 24, 1478–1485.
Mercier, G., Lennon, A. M., Renouf, B., et al. (2004). MAP kinase activation by fluoxetine and its relation to gene expression in cultured rat astrocytes. Journal of Molecular Neuroscience, 24, 207–216.
Mill, J., Tang, T., Kaminsky, Z., et al. (2008). Epigenomic profiling reveals DNA-methylation changes associated with major psychosis. American Journal of Human Genetics, 82, 696–711.
Minguet, E. G., Vera-Sirera, F., Marina, A., Carbonell, J., & Blazquez, M. A. (2008). Evolutionary diversification in polyamine biosynthesis. Molecular Biology and Evolution, 25, 2119–2128.
Mitchell, J. B., Iny, L. J., & Meaney, M. J. (1990). The role of serotonin in the development and environmental regulation of type II corticosteroid receptor binding in rat hippocampus. Brain Research. Developmental Brain Research, 55, 231–235.
Molnar, B. E., Berkman, L. F., & Buka, S. L. (2001). Psychopathology, childhood sexual abuse and other childhood adversities: relative links to subsequent suicidal behaviour in the US. Psychological Medicine, 31, 965–977.
Murgatroyd, C., Patchev, A. V., Wu, Y., et al. (2009). Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nature Neuroscience, 12, 1559–1566.
Nakatani, N., Hattori, E., Ohnishi, T., et al. (2006). Genome-wide expression analysis detects eight genes with robust alterations specific to bipolar I disorder: relevance to neuronal network perturbation. Human Molecular Genetics, 15, 1949–1962.
Nelson, C. J., Santos-Rosa, H., & Kouzarides, T. (2006). Proline isomerization of histone H3 regulates lysine methylation and gene expression. Cell, 126, 905–916.
Nielsen, S. J., Schneider, R., Bauer, U. M., et al. (2001). Rb targets histone H3 methylation and HP1 to promoters. Nature, 412, 561–565.
Okano, M., XIE, S., & Li, E. (1998). Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. Nature Genetics, 19, 219–220.
Pandey, G. N., Ren, X., Rizavi, H. S., et al. (2008). Brain-derived neurotrophic factor and tyrosine kinase B receptor signalling in postmortem brain of teenage suicide victims. International Journal of Neuropsychopharmacology, 11, 1047–1061.
Pariante, C. M., & Lightman, S. L. (2008). The HPA axis in major depression: classical theories and new developments. Trends in Neurosciences, 31, 464–468.
Perroud, N., Paoloni-Giacobino, A., Prada, P., et al. (2011). Increased methylation of glucocorticoid receptor gene (NR3C1) in adults with a history of childhood maltreatment: a link with the severity and type of trauma. Translational Psychiatry, 1.
Pokholok, D. K., Harbison, C. T., Levine, S., et al. (2005). Genome-wide map of nucleosome acetylation and methylation in yeast. Cell, 122, 517–527.
Polesskaya, O. O., Aston, C., & Sokolov, B. P. (2006). Allele C-specific methylation of the 5-HT2A receptor gene: evidence for correlation with its expression and expression of DNA methylase DNMT1. Journal of Neuroscience Research, 83, 362–373.
Poulter, M. O., Du, L., Weaver, I. C., et al. (2008). GABAA receptor promoter hypermethylation in suicide brain: implications for the involvement of epigenetic processes. Biological Psychiatry, 64, 645–652.
Pray-Grant, M. G., Daniel, J. A., Schieltz, D., Yates, J. R., 3rd & Grant, P. A. (2005). Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation. Nature, 433, 434–438.
Pruunsild, P., Kazantseva, A., Aid, T., Palm, K., & Timmusk, T. (2007). Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters. Genomics, 90, 397–406.
Radtke, K. M., Ruf, M., Gunter, H. M., et al. (2011). Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor. Translational Psychiatry, 1, 1–6.
Razzoli, M., Domenici, E., Carboni, L., et al. (2011). A role for BDNF/TrkB signaling in behavioral and physiological consequences of social defeat stress. Genes, Brain and Behavior, 10(4), 424–433.
Rhee, H. J., Kim, E. J., & Lee, J. K. (2007). Physiological polyamines: simple primordial stress molecules. Journal of Cellular and Molecular Medicine, 11, 685–703.
Rogoz, Z., Skuza, G., & Legutko, B. (2005). Repeated treatment with mirtazepine induces brain-derived neurotrophic factor gene expression in rats. Journal of Physiology and Pharmacology, 56, 661–671.
Rose, C. R., Blum, R., Pichler, B., et al. (2003). Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells. Nature, 426, 74–78.
Roth, T. L., Lubin, F. D., Funk, A. J., & Sweatt, J. D. (2009). Lasting epigenetic influence of early life adversity on the BDNF gene. Biological Psychiatry, 65, 760–769.
Roth, T. L., Zoladz, P. R., Sweatt, J. D., & Diamond, D. M. (2011). Epigenetic modification of hippocampal Bdnf DNA in adult rats in an animal model of post-traumatic stress disorder. Journal of Psychiatric Research, 45(7), 919–926.
Salcedo-Amaya, A. M., Van Driel, M. A., Alako, B. T., et al. (2009). Dynamic histone H3 epigenome marking during the intraerythrocytic cycle of Plasmodium falciparum. Proceedings of the National Academy of Sciences U S A, 106(24), 9655–9660.
Sanders, S. L., Portoso, M., Mata, J., et al. (2004). Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage. Cell, 119, 603–614.
Santa Mina, E. E., & Gallop, R. M. (1998). Childhood sexual and physical abuse and adult self-harm and suicidal behaviour: a literature review. Canadian Journal of Psychiatry, 43, 793–800.
Santos-Rosa, H., Schneider, R., Bernstein, B. E., et al. (2003). Methylation of histone H3 K4 mediates association of the Isw1p ATPase with chromatin. Molecular Cell, 12, 1325–1332.
Scher, C. D., Forde, D. R., Mcquaid, J. R., & Stein, M. B. (2004). Prevalence and demographic correlates of childhood maltreatment in an adult community sample. Child Abuse and Neglect, 28, 167–180.
Sen, S., Duman, R., & Sanacora, G. (2008). Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications. Biological Psychiatry, 64, 527–532.
Sequeira, A., Gwadry, F. G., Ffrench-Mullen, J. M., et al. (2006). Implication of SSAT by gene expression and genetic variation in suicide and major depression. Archives of General Psychiatry, 63, 35–48.
Sequeira, A., Klempan, T., Canetti, L., et al. (2007). Patterns of gene expression in the limbic system of suicides with and without major depression. Molecular Psychiatry, 12, 640–655.
Smythe, J. W., Rowe, W. B., & Meaney, M. J. (1994). Neonatal handling alters serotonin (5-HT) turnover and 5-HT2 receptor binding in selected brain regions: relationship to the handling effect on glucocorticoid receptor expression. Brain Research. Developmental Brain Research, 80, 183–189.
Stein, M. B., Koverola, C., Hanna, C., Torchia, M. G., & Mcclarty, B. (1997). Hippocampal volume in women victimized by childhood sexual abuse. Psychological Medicine, 27, 951–959.
Sun, H., Kennedy, P. J., & Nestler, E. J. (2013). Epigenetics of the depressed brain: role of histone acetylation and methylation. Neuropsychopharmacology, 38, 124–137.
Swigut, T., & Wysocka, J. (2007). H3K27 demethylases, at long last. Cell, 131, 29–32.
Tahiliani, M., Koh, K. P., Shen, Y., et al. (2009). Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science, 324, 930–935.
Tamura, Y., Kunugi, H., Ohashi, J., & Hohjoh, H. (2007). Epigenetic aberration of the human REELIN gene in psychiatric disorders. Molecular Psychiatry, 12, 519, 593–600.
Tanskanen, A., Hintikka, J., Honkalampi, K., et al. (2004). Impact of multiple traumatic experiences on the persistence of depressive symptoms: a population-based study. Nordic Journal of Psychiatry, 58, 459–464.
Torrey, E. F., Barci, B. M., Webster, M. J., et al. (2005). Neurochemical markers for schizophrenia, bipolar disorder, and major depression in postmortem brains. Biological Psychiatry, 57, 252–260.
Tsankova, N. M., Berton, O., Renthal, W., et al. (2006). Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nature Neuroscience, 9, 519–525.
Tucker, K. L. (2001). Methylated cytosine and the brain: a new base for neuroscience. Neuron, 30, 649–652.
Turecki, G., Briere, R., Dewar, K., et al. (1999). Prediction of level of serotonin 2A receptor binding by serotonin receptor 2A genetic variation in postmortem brain samples from subjects who did or did not commit suicide. American Journal of Psychiatry, 156, 1456–1458.
Turner, J. D., & Muller, C. P. (2005). Structure of the glucocorticoid receptor (NR3C1) gene 5’ untranslated region: identification, and tissue distribution of multiple new human exon 1. Journal of Molecular Endocrinology, 35, 283–292.
Turner, J. D., Pelascini, L. P., Macedo, J. A., & Muller, C. P. (2008). Highly individual methylation patterns of alternative glucocorticoid receptor promoters suggest individualized epigenetic regulatory mechanisms. Nucleic Acids Research, 36, 7207–7218.
Turner, J. D., Alt, S. R., Cao, L., et al. (2010). Transcriptional control of the glucocorticoid receptor: CpG islands, epigenetics and more. Biochemical Pharmacology, 80, 1860–1868.
Tyrka, A. R., Price, L. H., Marsit, C., Walters, O. C., & Carpenter, L. L. (2012). Childhood adversity and epigenetic modulation of the leukocyte glucocorticoid receptor: preliminary findings in healthy adults. PLoS One, 7, e30148.
Uddin, M., Aiello, A. E., Wildman, D. E., et al. (2010). Epigenetic and immune function profiles associated with posttraumatic stress disorder. Proceedings of the National Academy of Sciences U S A, 107, 9470–9475.
Veldic, M., Caruncho, H. J., Liu, W. S., et al. (2004). DNA-methyltransferase 1 mRNA is selectively overexpressed in telencephalic GABAergic interneurons of schizophrenia brains. Proceedings of the National Academy of Sciences U S A, 101, 348–353.
Volk, D. W., Austin, M. C., Pierri, J. N., Sampson, A. R., & Lewis, D. A. (2000). Decreased glutamic acid decarboxylase67 messenger RNA expression in a subset of prefrontal cortical gamma-aminobutyric acid neurons in subjects with schizophrenia. Archives of General Psychiatry, 57, 237–245.
Wang, Z., Zang, C., Rosenfeld, J. A., et al. (2008). Combinatorial patterns of histone acetylations and methylations in the human genome. Nature Genetics, 40, 897–903.
Weaver, I. C., Cervoni, N., Champagne, F. A., et al. (2004). Epigenetic programming by maternal behavior. Nature Neuroscience, 7, 847–854.
Wysocka, J., Swigut, T., Milne, T. A., et al. (2005). WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development. Cell, 121, 859–872.
Wysocka, J., Swigut, T., Xiao, H., et al. (2006). A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling. Nature, 442, 86–90.
Xiao, T., Shibata, Y., Rao, B., et al. (2007). The RNA polymerase II kinase Ctk1 regulates positioning of a 5’ histone methylation boundary along genes. Molecular and Cellular Biology, 27, 721–731.
Xu, H., Chen, Z., He, J., et al. (2006). Synergetic effects of quetiapine and venlafaxine in preventing the chronic restraint stress-induced decrease in cell proliferation and BDNF expression in rat hippocampus. Hippocampus, 16, 551–559.
Zhang, T. Y., Hellstrom, I. C., Bagot, R. C., et al. (2010). Maternal care and DNA methylation of a glutamic acid decarboxylase 1 promoter in rat hippocampus. Journal of Neuroscience, 30, 13 130–13 137.
Zhou, Z., Hong, E. J., Cohen, S., et al. (2006). Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation. Neuron, 52, 255–269.
Zlotnick, C., Mattia, J., & Zimmerman, M. (2001). Clinical features of survivors of sexual abuse with major depression. Child Abuse and Neglect, 25, 357–367.