This chapter describes the process of ComB treatment implementation, in which the “active ingredients” are introduced that that are chosen to reduce the power of antecedent cues, to divert the individual’s ability to engage in their BFRB, and to provide alternative means for achieving reinforcing outcomes that encourage and perpetuate BFRB activity. The process of introducing appropriate interventions is described in detail, with emphases on fitting interventions to each client’s needs and preferences. The reader is guided through methods for choosing specific interventions, monitoring their effectiveness, and making decisions about modifying the intervention plan as therapy moves forward. The SCAMP formulation is revisited to illustrate how specific interventions within each of the five domains draw upon tried-and-true cognitive behavioral techniques that can be incorporated in problem-solving common difficulties encountered within each domain.