Skip to main content Accessibility help
×
Hostname: page-component-7479d7b7d-q6k6v Total loading time: 0 Render date: 2024-07-11T14:13:09.910Z Has data issue: false hasContentIssue false

6.2 - The Stress Response and Glucocorticoids

from 6 - Modulators

Published online by Cambridge University Press:  08 November 2023

Mary-Ellen Lynall
Affiliation:
University of Cambridge
Peter B. Jones
Affiliation:
University of Cambridge
Stephen M. Stahl
Affiliation:
University of California, San Diego
Get access

Summary

This section summarises the psychology and neurobiology of stress responses in humans. It considers the adaptive value of stress in enabling humans to detect real or perceived threats in the environment and, through learning, to build resilience through helpful coping responses. The conditions that favour ‘toxic’ forms of stress to prevail and so cause chronic metabolic, inflammatory and cognitive disorders are highlighted and discussed from the perspective of dysregulated cortisol signalling.

Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2023

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Argentieri, MA, Nagarajan, S, Seddighzadeh, B, Baccarelli, AA, Shields, AE (2017). Epigenetic pathways in human disease: the impact of DNA methylation on stress-related pathogenesis and current challenges in biomarker development. EBioMedicine 18: 327350.CrossRefGoogle ScholarPubMed
de Kloet, ER, de Kloet, SF, de Kloet, CS, de Kloet, AD (2019). Top-down and bottom-up control of stress-coping. J Neuroendocrinol 31: e12675.CrossRefGoogle ScholarPubMed
Dias-Ferreira, E, Sousa, JC, Melo, I et al. (2009). Chronic stress causes frontostriatal reorganization and affects decision-making. Science 325: 621625.CrossRefGoogle ScholarPubMed
Koolhaas, JM, Bartolomucci, A, Buwalda, B et al. (2011). Stress revisited: a critical evaluation of the stress concept. Neurosci Biobehav Rev 35: 12911301.CrossRefGoogle ScholarPubMed
McEwen, BS, Gianaros, PJ (2011). Stress- and allostasis-induced brain plasticity. Annu Rev Med 62: 431445.CrossRefGoogle ScholarPubMed
Selye, H (1955). Stress and disease. Science 122: 625631.CrossRefGoogle ScholarPubMed
Uno, H, Tarara, R, Else, JG, Suleman, MA, Sapolsky, RM (1989). Hippocampal damage associated with prolonged and fatal stress in primates. J Neurosci 9: 17051711.CrossRefGoogle ScholarPubMed
van der Goes, MC, Jacobs, JW, Bijlsma, JW (2014). The value of glucocorticoid co-therapy in different rheumatic diseases: positive and adverse effects. Arthritis Res Ther 16: S2.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×