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  • Print publication year: 2020
  • Online publication date: February 2020

1c - Illustrating the Value of Neuroimaging Studies Using the Example of Affect Regulation: Author Rejoinder to Commentaries on Neuroimaging in Personality Disorders

from Part I - Etiology

Summary

This rejoinder uses the neuroimaging literature on affect regulation to exemplify how integration of complementary methods suggested by the commentaries could advance neurobiological understanding of personality disorders. It illustrates progressive insights gained from incorporating multiple sources of evidence including neuroimaging, genetics, and behavioral data associated with affect regulation. It also demonstrates the use of brain pattern activation analysis in addition to studying individual regions of interest to better understand the complex relationships between biological genotype, brain activity, and behavioral phenotype. The ways in which neuroimaging can serve as an endophenotype to bridge the gap between genes and distant phenotypes are highlighted.

Bastiaansen, J. A., Servaas, M. N., Marsman, J. B. C., Ormel, J., Nolte, I. M., Riese, H., & Aleman, A. (2014). Filling the gap: Relationship between the serotonin-transporter-linked polymorphic region and amygdala activation. Psychological Science, 25(11), 20582066.
Broome, M. R., He, Z., Iftikhar, M., Eyden, J., & Marwaha, S. (2015). Neurobiological and behavioural studies of affective instability in clinical populations: A systematic review. Neuroscience & Biobehavioral Reviews, 51, 243254.
Calati, R., Gressier, F., Balestri, M., & Serretti, A. (2013). Genetic modulation of borderline personality disorder: Systematic review and meta-analysis. Journal of Psychiatric Research, 47(10), 12751287.
Hankin, B. L., Barrocas, A. L., Jenness, J., Oppenheimer, C. W., Badanes, L. S., Abela, J. R. Z., … Smolen, A. (2011). Association between 5-HTTLPR and borderline personality disorder traits among youth. Frontiers in Psychiatry, 2, 6.
Hariri, A. R., & Holmes, A. (2006). Genetics of emotional regulation: The role of the serotonin transporter in neural function. Trends in Cognitive Sciences, 10(4), 182191.
Klucken, T., Schweckendiek, J., Blecker, C., Walter, B., Kuepper, Y., Hennig, J., & Stark, R. (2015). The association between the 5-HTTLPR and neural correlates of fear conditioning and connectivity. Social Cognitive and Affective Neuroscience, 10(5), 700707.
Madsen, M. K., McMahon, B., Andersen, S. B., Siebner, H. R., Knudsen, G. M., & Fisher, P. M. (2016). Threat-related amygdala functional connectivity is associated with 5-HTTLPR genotype and neuroticism. Social Cognitive and Affective Neuroscience, 11(1), 140149.
Maurex, L., Zaboli, G., Ohman, A., Asberg, M., & Leopardi, R. (2010). The serotonin transporter gene polymorphism (5-HTTLPR) and affective symptoms among women diagnosed with borderline personality disorder. European Psychiatry: The Journal of the Association of European Psychiatrists, 25(1), 1925.
Munafò, M. R., Brown, S. M., & Hariri, A. R. (2008). Serotonin transporter (5-HTTLPR) genotype and amygdala activation: A meta-analysis. Biological Psychiatry, 63(9), 852857.
Munafò, M. R., Clark, T., & Flint, J. (2005). Does measurement instrument moderate the association between the serotonin transporter gene and anxiety-related personality traits? A meta-analysis. Molecular Psychiatry, 10(4), 415419.
Munafò, M. R., Freimer, N. B., Ng, W., Ophoff, R., Veijola, J., Miettunen, J., … Flint, J. (2009). 5-HTTLPR genotype and anxiety-related personality traits: A meta-analysis and new data. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 150B(2), 271281.
Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., … Weinberger, D. R. (2005). 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: A genetic susceptibility mechanism for depression. Nature Neuroscience, 8(6), 828834.
Sen, S., Burmeister, M., & Ghosh, D. (2004). Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 127B(1), 8589.