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  • Print publication year: 2020
  • Online publication date: February 2020

1c - Illustrating the Value of Neuroimaging Studies Using the Example of Affect Regulation: Author Rejoinder to Commentaries on Neuroimaging in Personality Disorders

from Part I - Etiology


This rejoinder uses the neuroimaging literature on affect regulation to exemplify how integration of complementary methods suggested by the commentaries could advance neurobiological understanding of personality disorders. It illustrates progressive insights gained from incorporating multiple sources of evidence including neuroimaging, genetics, and behavioral data associated with affect regulation. It also demonstrates the use of brain pattern activation analysis in addition to studying individual regions of interest to better understand the complex relationships between biological genotype, brain activity, and behavioral phenotype. The ways in which neuroimaging can serve as an endophenotype to bridge the gap between genes and distant phenotypes are highlighted.

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