This chapter deals with the critical issue of developing an effective culture, to more readily allow for innovations, say in research or in pedagogy. Partly such a change-prone culture might be impacted from the Dean/President at the top. Partly also there must be a bottom-up focus at work. And, it is this positive tension between top-down and bottom-up that might lead to an effective change culture. Ethics are of course key here, to inspire “good can become even better”.