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  • Print publication year: 2018
  • Online publication date: February 2018

Chapter 8 - Diencephalon: Hypothalamus and Epithalamus

Gumz, M. L. (Ed.). (2016). Circadian Clocks: Role in Health and Disease. New York NY: Springer.
Swaab, D. F. (2003–2004). The Human Hypothalamus: Basic and Clinical Aspects. Handbook of Clinical Neurology (vol. 93, 80) Amsterdam: Elsevier.
Akhter, S., Marcus, M., Kerber, R. A., Kong, M., and Taylor, K. C. (2016). The impact of periconceptional materal stress on fecundability. Ann. Epidemiology, 26(10), 710716.e7. doi:10.1016/j.annepidem.2016.07.015
Amat, J., Sparks, P. D., Matus-Amat, P., Griggs, J., Watkins, L. R., and Maier, S. F. (2001). The role of the habenular complex in the elevation of dorsal raphe nucleus serotonin and the changes in the behavioral responses produced by uncontrollable stress. Brain. Resh., 917, 118126. doi:10.1016/s0006-8993(01)02934–1
Asarnow, L. D., Soehner, A. M., and Harvey, A. G. (2013). Circadian rhythms and psychiatric illness. Curr. Opin. Psychiatry, 26(6), 566571. doi:10.1097/YCO.0b013e328365a2fa
Benarroch, E. E. (2008). Suprachiasmatic nucleus and melatonin. Reciprocal interactions and clinical correlations. Neurology, 71(5), 594598. doi:10.1212/01.wnl.0000324283.57261.37
Benedetti, F., Barbini, B., Fulgosi, M. C., Colombo, C., Dallaspezia, S., Pontiggia, A., and Smeraldi, E. (2005). Combined total sleep deprivation and light therapy in the treatment of drug-resistant bipolar depression: acute response and long-term remission rates. J. Clin. Psychiatry, 66, 15351540. Retrieved from www.ncbi.nlm.nih.gov/pubmed/16401154
Beretta, C. A., Dross, N., Gutierrez-Triana, J. A., Ryu, S., and Carl, M. (2012). Habenula circuit development: past, present, and future. Neurogenesis, 6, 51. doi.org/10.3389/fnins.2012.00051
Bernstein, H. G., Hildebrandt, J., Dobrowolny, H., Steiner, J., Bogerts, B., and Pahnke, J. (2016). Morphometric analysis of the cerebral expression of ATP-binding cassette transporter protein ABCB1 in chronic schizophrenia: Circumscribed deficits in the habenula. Schizophr Res., 177(1–3), 5258. doi:10.1016/j.schres.2016.02.036
Bernstein, H. G., Klix, M., Dobrowolny, H., Brisch, R., Steiner, J., Bielau, H., Gos, T., and Bogerts, B. (2012). A postmortem assessment of mammillary body volume, neuronal number and densities, and fornix volume in subjects with mood disorders. Eur. Arch. Psychiatry Clin. Neurosci., 262(8), 637646. doi:10.1007/s00406-012–0300-4
Breningstall, G. N. (1985). Gelastic seizures, precocious puberty, and hypothalamic hamartomas. Neurology, 35, 11801183. doi:10.1093/brain/awr235
Buijs, F. N., León-Mercado, L., Guzmán-Ruiz, M., Guerrero-Vargas, N. N., Romo-Nava, F., and Buijs, R. M. (2016). The circadian system: a regulatory feedback network of periphery and brain. Physiology, 31(3), 170181. doi:10.1152/physiol.00037.2015
Burstein, R. (1996). Somatosensory and visceral input to the hypothalamus and limbic system. Prog. Brain Res., 107, 257267. doi:10.1016/S0079-6123(08)61869–5
Byne, W., Tobet, S., Mattiace, L. A., Lasco, M. S., Kemether, E., Edgar, M. A.,… Jones, L. B. (2001). The interstitial nuclei of the human anterior hypothalamus: an investigation of variation with sex, sexual orientation, and HIV status. Horm. Behav., 40, 8692. doi:10.1006/hbeh.2001.1680
Cajochen, C., Munch, M., Knoblauch, V., Blatter, K., and Wirz-Justice, A. (2006). Age-related changes in the circadian and homeostatic regulation of human sleep. Chronobiol. Int., 23, 461474. doi:10.1080/07420520500545813
Danilenko, K. V., Putilov, A. A., Russkikh, G. S., Duffy, L. K., and Ebbesson, S. O. (1994). Diurnal and seasonal variations of melatonin and serotonin in women with seasonal affective disorder. Arctic Med. Res., 53, 137145. doi:10.1016/j.biopsych.2008.11.020
Dantzer, R., O’Connor, J. C., Freund, G. G., Johnson, R. W., and Kelley, K. W. (2008). From inflammation to sickness and depression: When the immune system subjugates the brain. Nat. Rev. Neurosci., 9, 4656. doi:10.1038/nrn2297
Delville, Y. U., Melloni, R. H. Jr., and Ferris, C. F. (1998). Behavioral and neurobiological consequences of social subjugation during puberty in golden hamsters. J. Neurosci., 18, 26672672. Retrieved from www.ncbi.nlm.nih.gov/pubmed/9502824
Demitrack, M. A., and Gold, P. W. (1988). Oxytocin: Neurobiologic considerations and their implications for affective illness. Prog. Neuropsychopharmacol., 12, S23S51. Retrieved from www.ncbi.nlm.nih.gov/.pubmed/3074339
Demitrack, M. A., Lesem, M. D., Listwak, S. J., Brandt, H. A., Jimerson, D. C., and Gold, P. W. (1990). CSF oxytocin in anorexia nervosa and bulimia nervosa: Clinical and pathophysiological considerations. Am. J. Psychiatry, 147, 882886. Retrieved from www.ncbi.nlm.nih.gov/pubmed/2356873
DeMoranville, B. M., and Jackson, I. M. D. (1996). Psychoneuroendocrinology. In: Fogel, B. S., Schiffer, R. B., and Rao, S. M. (Eds.), Neuropsychiatry (pp. 173192). Baltimore, MD: Williams & Wilkins.
Dobolyi, A., Grattan, D. R., and Stolzenberg, D. S. (2014). Preoptic inputs and mechanisms that regulate maternal responsiveness. J. Neuroendocrinol., 26(10), 627640. doi:10.1111/jne.12185
Ellison, G. (1994). Stimulant-induced psychosis, the dopamine theory of schizophrenia and the habenula. Brain Res. Rev., 19, 223239. Retrieved from www.ncbi.nlm.nih.gov/pubmed/7914793
Elman, I., Borsook, D., and Volkow, N. D. (2013). Pain and suicidality: Insights from reward and addiction neuroscience. Prog. Neurobiol., 109, 127. doi:10.1016/j.pneurobio.2013.06.003
Fakhoury, M., and López, S. D. (2014). The role of habenula in motivation and reward. Adv. Neurosci., Article ID S62048. doi:10.1155/2014/862048
Fontes, M. A. P., Xavier, C. H., de Menezes, R. C. A., and DiMicco, J. A. (2011). The dorsomedial hypothalamus and the central pathways involved in the cardiovascular response to emotional stress. Cogn. Behav. Sys. Neurosci., 184, 6474. doi:10.1016/j.neuroscience.2011.03.018
Friedman, A., Lax, E., Dikshtein, Y., Abraham, L., Flaumenhaft, Y., Sudai, E.,… Yadid, G. (2011). Electrical stimulation of the lateral habenula produces an inhibitory effect on sucrose self-administration. Neuropharmacology, 60, 381387. doi:10.1016/j.neuropharm.2010.10.006
Gamble, K. L., Resuehr, D., and Johnson, C. H. (2013). Shift work and circadian dysregulation of reproduction. Front. Endocrinol., 4, 92. doi:10.3389/fendo.2013.00092
Garcia-Falgueras, A., and Swaab, D. F. (2008), A sex difference in the hypothalamic uncinate nucleus: relationship to gender identity. Brain, 131(12), 31323146. doi:10.1093/brain/awn276
Garcia-Falgueras, A., Ligtenberg, L., Kruijver, F. P. M., and Swaab, D. F. (2011). Galanin neurons in the intermediate nucleus (InM) of the human hypothalamus in relation to sex, age, and gender identity. J. Comp. Neurol., 519, 30613084. doi:10.1002/cne.22666View
Geisler, S., and Trimble, M. (2008). The lateral habenula: No longer neglected. CNS Spectrums, 13(6), 484489. doi:10.1017/S1092852900016710
Goel, N., Terman, M., Terman, J. S., Macchi, M. M., and Stewart, J. W. (2005). Controlled trial of bright light and negative air ions for chronic depression. Psychol. Med., 35, 945955. doi:10.1017/S0033291705005027
Goldstein, J. M., Seidman, L. J., Makris, N., Ahern, T., O’Brien, L. M., Caviness, V. S. Jr.,… Tsuang, M. T. (2006). Hypothalamic abnormalities in schizophrenia: Sex effects and genetic vulnerability. Biol. Psychiatry, 61, 935945. doi:10.1016/j.biopsych.2006.06.027
Hernando, V., Pastor, J., Pedrosa, M., Peña, E., and Sola, R. G. (2008). Low-frequency bilateral hypothalamic stimulation for treatment of drug-resistant aggressiveness in a young man with mental retardation. Stereotact. Funct. Neurosurg., 86, 219220. doi:10.1159/000131659
Hikosaka, O. (2010). The habenula: from stress-evasion to value-based decision making. Nat. Rev. Neurosci., 11, 503513. doi:10.1038/nrn2866
Hikosaka, O., Sesack, S. R., Lecourtier, L., and Shepard, P. D. (2008). Habenula: Crossroad between the basal ganglia and the limbic system. J. Neurosci., 28(46), 1182511829. doi:10.1523/JNEUROSCI.3463–08.2008
Holsboer-Trachsler, E., Stohler, R., and Hatzinger, M. (1991). Repeated administration of the combined dexamethasone–human corticotropin releasing hormone stimulation test during treatment of depression. Psychiatry Res., 38, 163171. doi:10.1016/0165–1781(91)90041-M
Iwasaki, H., Jodo, E., Kawauchi, A., Miki, T., Kayama, Y., and Koyama, Y. (2010). Role of the lateral preoptic area and the bed nucleus of stria terminalis in the regulation of penile erection. Brain Res., 1357, 7078. doi:10.1016/j.brainres.2010.08.006
Kim, U., and Chang, S. Y. (2005). Dendritic morphology, local circuitry, and intrinsic electrophysiology of neurons in the rat medial and lateral habenular nuclei of the epithalamus. J. Comp. Neurol., 483(2), 236250. doi:10.1002/cne.20410
King, B. M. (2006). The rise, fall and resurrection of the ventromedial hypothalamus in the regulation of feeding behavior and body weight. J. Physiol. Behav., 87(2), 221244. doi:10.1016/j.physbeh.2005.10.007
Koob, G. F., and Le Moal, M. (2008). Addiction and the brain antireward system. Annu. Rev. Psychol., 59, 2953. doi:10.1146/annurev.psych.59.103006.093548
Kostic, V. S., Stefanova, E., Svetel, M., and Kozic, D. (1998). A variant of the Kleine-Levin syndrome following head trauma. Behav. Neurol., 11(2), 105108. doi:10.1155/1998/413989
Kremer, H. P. H. (1992). The hypothalamic lateral tuberal nucleus: Normal anatomy and changes in neurological diseases. Prog. Brain Res., 111, 249261. Retrieved from www.ncbi.nlm.nih.gov/pubmed/1362279
Lecourtier, L., DeFrancesco, A. and Moghaddam, B., (2008). Differential tonic influence of lateral habenula on prefrontal cortex and nucleus accumbens dopamine release. European Journal of Neuroscience, 27(7), 17551762.
Lecourtier, L., and Kelly, P. H. (2007). A conductor hidden in the orchestra? Role of the habenular complex in monoamine transmission and cognition. Neurosci. Biobehav. Rev., 31(5), 658672. doi:10.1016/j.neubiorev.2007.01.004
Legros, J. J., Ansseau, M., and Timsit-Berthier, M. (1993). Neurohypophyseal peptides and psychopathology. Prog. Brain Res., 93, 455461. doi:10.1016/S0079-6123(08)64589–6
Li, B., Piriz, J., Mirrione, M., Chung, C., Proulx, C. D., Schulz, D.,… Malinow, R. (2011). Synaptic potentiation onto habenula neurons in the learned helplessness model of depression. Nature, 470, 535539. doi:10.1038/nature09742
Li, C., and Zhou, X. (2015). Melatonin and male reproduction. Clin. Chim. Acta, 446, 175180. doi:10.1016/j.cca.2015.04.029
Li, J., Hu, Z., and de Lecea, L. (2014). The hypocretins/orexins: integrators of multiple physiological functions. Brit. J. Pharmacol., 171(2), 332350. doi:10.1111/bph.12415
Maier, S. F. and Watkins, L. R. (2010). Role of the medial prefrontal cortex in coping and resilience. Brain Resh., 1355, 5260. doi:10.1016/j.brainres.2010.08.039
Maley, J. H., Alvernia, J. E., Valle, E. P., and Richardson, D. (2010). Deep brain stimulation of the orbitofrontal projections for the treatment of intermittent explosive disorder. Neurosurg. Focus, 29(2), E11. doi:10.3171/2010.5
Matsumoto, M., and Hikosaka, O. (2007). Lateral habenula as a source of negative reward signals in dopamine neurons. Nature, 447, 11111115. doi:10.1038/nature05860
Matsumoto, M., and Hikosaka, O. (2009). Representation of negative motivational value in the primate lateral habenula. Nat. Neurosci., 12(1), 7784. doi:10.1038/nn.2233
McHenry, J. A., Rubinow, D. R., and Stuber, G. D. (2015). Maternally responsive neurons in the bed nucleus of the stria terminalis and medial preoptic area: Putative circuits for regulating anxiety and reward. Front. Neuroendocrinol., 38, 6572. doi:10.1016/j.yfrne.2015.04.001
Meye, F. J. Lecca, S., Valentinova, K., and Mameli, M. (2013). Synaptic and cellular profile of neurons in the lateral habenula. Front. Hum. Neurosci., 7. 860. doi:10.3389/fnhum.2013.00860
Mitchell, J., O’Neil, J., Janabi, M., Marks, S., Jagust, W., and Fields, H. (2012). Alcohol consumption induces endogenous opioid release in the human orbitofrontal cortex and nucleus accumbens. Sci. Translat. Med., 4(116), 116ra6. doi:10.1126/scitranslmed.3002902
Møller, M. and Baeres, F. M. M. (2002). The anatomy and innervation of the mammalian pineal gland. Cell Tissue Res., 309, 139150. doi:10.1007/s00441-002–0580-5
Moura, D., Canavarro, M. C., and Figueiredo-Braga, M. (2016). Oxytocin and depression in the perinatal period – a systematic review. Arch. Womens Ment. Health, 19(4), 561570. doi:10.1007/s00737-016–0643-3
Murakami, G. (2016). Distinct effects of estrogen on mouse maternal behavior: The contribution of estrogen synthesis in the brain. PLos ONE. doi:10.1371/journal.pone.0150728
Nadvornik, P., Sramka, M., and Patoprsta, G. 1975. Transventricular anterior hypothalamotomy in stereotactic treatment of hedonia. In : Sweet, W. H., Obrador, S., and Martin-Rodriguez, J. G. (Eds.), Neurosurgical Treatment in Psychiatry, Pain and Epilepsy. (pp. 445450). Baltimore, MD: University Park Press.
Pankhurst, M. W., and McLennan, I. S. (2012). Inhibin B and anti-Müllerian hormone/Müllerian-inhibiting substance may contribute to the male bias in autism. Trans. Psychiatry, 2, p. e148. doi:10.1038/tp.2012.72
Paredes, R. G. (2003). Medial preoptic area/anterior hypothalamus and sexual motivation. Scand. J. Psychol., 44(3), 203212. doi:10.1111/1467–9450.00337
Partch, C. L., Green, C. B., and Takahashi, J. S. (2014). Molecular architecture of the mammalian circadian clock. Trends Cell. Biol., 24, 9099. doi:10.1016/j.tcb.2013.07.002
Pedersen, C. A. (1997). Oxytocin control of maternal behavior: Regulation by sex steroids and offspring stimuli. Ann. N. Y. Acad. Sci., 807, 126145. doi:10.1111/j.1749–6632.1997
Pedersen, C. A., and Prange, A. J. Jr. (1979). Induction of maternal behavior in virgin rats after intracerebroventricular administration of oxytocin. Proc. Natl. Acad. Sci. U. S. A., 76, 66616665. Retrieved from www.ncbi.nlm.nih.gov/pubmed/293752
Raadsheer, F. C., Hoogendijk, W. J. G., Stam, F. C., Tilders, F. J. H., and Swaab, D. F. (1994). Increased number of corticotropin-releasing hormone neurons in the hypothalamic paraventricular nuclei of depressed patients. Neuroendocrinol., 60, 436444. Retrieved from www.ncbi.nlm.nih.gov/pubmed/7824085
Reiter, R. J., Tamura, H., Tan, D. X., and Xu, X. Y. (2014). Melatonin and the circadian system: contributions to successful female reproduction. Fertil. Steril., 102(2), 321328. doi:10.1016/j.fertnstert.2014.06.014
Riemann, D., Berger, M., and Voderholzer, U. (2001). Sleep and depression: results from psychobiological studies. Biol. Psychol., 57, 67103. doi:10.1016/S0301-0511(01)00090–4
Roiser, J. P., Elliott, R., and Sahakian, B. J. (2012). Cognitive mechanisms of treatment in depression. Neuropsychopharm., 37, 117136. doi:10.1038/npp.2011.183
Rosenblatt, J. S. and Ceus, K. (1998). Estrogen implants in the medial preoptic area stimulate maternal behavior in male rats. Hormones Behavior, 33(1), 2330. doi:10.1006/hbeh.1997.1430
Ross, E. D., and Stewart, R. M. (1981). Akinetic mutism from hypothalamic damage: Successful treatment with dopamine agonists. Neurology, 31(11), 14351439. Retrieved from www.ncbi.nlm.nih.gov/pubmed/6118841
Rutigliano, G., Rocchetti, M., Paloyelis, Y., Gileen, J., Sardella, A., Capucciati, M.,… Fusar-Poli, P. (2016). Peripheral oxytocin and vasopressin: Biomarkers of psychiatric disorders? A comprehensive systematic review and preliminary meta-analysis. Psychiatry Res., 241, 207220. doi:10.1016/j.psychres.2016.04.117
Sandyk, R. (1992). Pineal and habenula calcification in schizophrenia. Internat. J. Neurosci., 67, 1930. Retrieved from www.ncbi.nlm.nih.gov/pubmed/1305634
Saper, C. B. (2012). Hypothalamus. In Mai, J. K., and Paxinos, G. (Eds.), The Human Nervous System (3rd edn., pp. 548583). New York, NY: Elsevier.
Sartorius, A., Kiening, K. I., Kirsch, P., von Gall, C. C., Haberkorn, U., Unterberg, A. W.,…. Meyer-Lindberg, A. (2010). Remission of major depression under deep brain stimulation of the lateral habenula in a therapy-refractory patient. Biol. Psychiatry, 67, e9e11. doi:10.1016/j.biopsych.2009.08.027
Savic, D., Knezevic, G., Matic, G., Damjanovic, S., and Spiric, Z. (2015). Posttraumatic and depressive symptoms in β-endorphin dynamics. J. Affect. Disord., 181, 6166. doi:10.1016/j.jad.2015.03.063
Schaap, J., and Meijer, J. H. (2001). Opposing effects of behavioural activity and light on neurons of the suprachiasmatic nucleus. Eur. J. Neurosci., 13, 19551962. doi:10.1046/j.0953-816x.2001.01561.x
Schmidt, M. H., Valatx, J. L., Sakai, K., Fort, P., and Jouvet, M. (2000). Role of the lateral preoptic area in sleep-related erectile mechanisms and sleep generation in the rat. J. Neurosci., 20, 66406647. Retrieved from www.ncbi.nlm.nih.gov/pubmed/10964969
Sechi, G., and Serra, A. (2007). Wernicke’s encephalopathy: New clinical settings and recent advances in diagnosis and management. Lancet Neurology, 6, 442455. doi:10.1016/S1474-4422(07)70104–7
Shipley, M. T., Murphy, A. Z., Rizvi, T. A., Ennis, M., and Behbehani, M. M. (1996). Olfaction and brainstem circuits of reproductive behavior in the rat. Prog. Brain Res., 107, 355377. Retrieved from www.ncbi.nlm.nih.gov/pubmed/8782531
Shumake, J., Edwards., E., and Gonzalez-Lima, F. (2003). Opposite metabolic changes in the habenula and ventral tegmental area of a genetic model of helpless behavior. Brain Resh., 963, 274281. doi:10.1016/S0006-8993(02)04048–9
Silva, B. A., Mattucci, C., Krzywkowski, P., Murana, E., Illarionova, A., Grinevich, V.,… Gross, C. T. (2013). Independent hypothalamic circuits for social and predator fear. Nature Neurosci., 16, 17311733. doi:10.1038/nn.3573
Song, J., Kim, E., Kim, C-H., Song, H-T., and Lee, J. E. (2015). The role of orexin in post-stroke inflammation, cognitive decline, and depression. Mol. Brain, 8, 16. doi:10.1186/s13041-015–0106-1
Srinivasan, V., De Berardis, D., Shillcutt, S. D., and Brzezinski, A. (2012). Role of melatonin in mood disorders and the antidepressant effects of agomelatine. Exp. Opin. Investigat. Drugs, 21(10), 15031522. doi:10.1517/13543784.2012.711314
Stoléru, S., Fonteille, V., Cornélis, C., Joyal, C., and Moulier, V. (2012). Functional neuroimaging studies of sexual arousal and orgasm in healthy men and women: A review and meta-analysis. Neurosci. Biobehav. Rev., 36(6), 14811509. doi:10.1016/j.neubiorev.2012.03.006
Stuebe, A. M., Grewen, K., Pedersen, C. A., Propper, C., and Meltzer-Brody, S. (2012). Failed lactation and perinatal depression: common problems with shared neuroendocrine mechanisms? J. Womans Health, 21(3), 32643272. doi:10.1089/jwh.2011.3083
Tahara, Y., and Shibata, S. (2013). Chronobiology and nutrition. Neurosci., 253, 7888. doi:10.1016/j.neuroscience.2013.08.049
Takeuchi, J., Handa, H., and Miki, Y. (1979). Precocious puberty due to hypothalamic hamartoma. Surg. Neurol., 11, 456460. doi:10.4103/2230–8210.98027
Teitelbaum, P., and Epstein, A. N. (1962). The lateral hypothalamic syndrome: recovery of feeding and drinking after lateral hypothalamic lesions. Psychol. Rev., 69, 7490. doi:10.1037/h0039285
Thannickal, T. C., Moore, R. Y., Nienhuis, R., Moore, R. Y., Nienhuis, R., Ramanathan, L.,… Siegel, J. M. (2000). Reduced number of hypocretin neurons in human narcolepsy. Neuron, 27, 469474. doi:10.1016/S0896-6273(00)00058–1
Tonkonogy, J. M., and Geller, J. L. 1992. Hypothalamic lesions and intermittent explosive disorder. J. Neuropsychiatry Clin. Neurosci., 4, 4550. doi:10.1176/jnp.4.1.45
Ullsperger, M., and von Cramon, D. Y. (2003). Error monitoring using external feedback: Specific roles of the habenular complex, the reward system, and the cingulate motor area revealed by functional magnetic resonance imaging. J. Neurosci., 23(10), 43084314. Retrieved from www.ncbi.nlm.nih.gov/pubmed/12764119
Urban-Kowalczyk, M., Śmigielski, J., and Strzelecki, D. (2016). Comparison of beta-endorphin and CGRP levels before and after treatment for severe schizophrenia. Neuropsychiatr. Dis. Treat., 12, 863868. doi:10.2147/NDT.S101647
Van de Poll, N. E., and Van Goozen, S. H. M. (1992). Hypothalamic involvement in sexuality and hostility: Comparative psychological aspects. Prog. Brain Res., 93, 343361. doi:10.1016/S0079-6123(08)64584–7
Vázquez-Borsetti, P., Celada, P., Cortés, R., and Artigas, F. (2011). Simultaneous projections from prefrontal cortex to dopaminergic and serotonergic nuclei. Int. J. Neuropsychopharmacol., 14(3), 289302. doi:10.1017/S1461145710000349
Veening, J. G., de Jong, T. R., Waldinger, M. D., Korte, S. M., and Olivier, B. (2015). The role of oxytocin in male and female reproductive behavior. Eur. J. Pharmacol., 753, 209228. doi:10.1016/j.ejphar.2014.07.045
Velasquez, K. M., Molfese, D. L., and Salas, R. (2014). The role of the habenula in drug addiction. Front. Hum. Neurosci., 8, 174. doi:10.3389/fnhum.2014.00174
Villarreal, J. S., Gonzalez-Lima, F., Berndt, J., and Barea-Rodriguez, E. J. (2002). Water maze training in aged rats: effects on brain metabolic capacity and behavior. Brain Res., 939(1–2), 4351. doi:10.1016/S0006-8993(02)02545–3
Viswanath, H., Carter, A. Q., Baldwin, P. R., Molfese, D. L., and Salas, R. (2013). The medial habenula: still neglected. Front. Hum. Neurosci., 7, 731. doi:10.3389/fnhum.2013.00931
Vreeburg, S. A., Hoogendijk, W. J., DeRijk, R. H., van Dyck, R., Smit, J. H., Zitman, F. G., and Penninx, B. W. (2013). Salivary cortisol levels and the 2-year course of depressive and anxiety disorders. Psychoneuroendocrinology, 38, 14941502. doi:10.1016/j.psyneuen.2012.12.017
Witt, D. W. (1997). Regulatory mechanisms of oxytocin-mediated sociosexual behavior. Ann. N. Y. Acad. Sci., 807, 287301. doi:10.1111/j.1749–6632.1997.tb51927.x
Wu, Y. H., and Swaab, D. F. (2007). Disturbance and strategies for reactivation of the circadian rhythm system in aging and Alzheimer’s disease. Sleep Med., 8, 623636. doi:10.1016/j.sleep.2006.11.010
Wulff, K., Gatti, S., Wettstein, J. G., and Foster, R. G. (2010). Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease. Nat. Rev. Neurosci., 11, 589599. doi:10.1038/nrn2868
Yang, L. M., Hu, B., Xia, Y. H., Zhang, B. L., and Zhao, H. (2008). Lateral habenula lesions improve the behavioral response in depressed rats via increasing the serotonin level in dorsal raphe nucleus. Behav. Brain Resh., 188, 8490. doi:10.1016/j.bbr.2007.10.022
Zhou, J. N., Hofman, M. A., Gooren, L. J., and Swaab, D. F. (1995). A sex difference in the human brain and its relation to transsexuality. Nature, 378, 6870. doi:10.1038/378068a0