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  • Print publication year: 2016
  • Online publication date: May 2016

17 - Biological factors in bipolar disorder in childhood and adolescence

Adleman, N. E., Kayser, R., Dickstein, D., et al. Neural correlates of reversal learning in severe mood dysregulation and pediatric bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2011;50:1173–85 e2.
Adleman, N. E., Fromm, S. J., Razdan, V., et al. Cross-sectional and longitudinal abnormalities in brain structure in children with severe mood dysregulation or bipolar disorder. J Child Psychol Psychiatry. 2012;53:1149–56.
Adleman, N. E., Kayser, R. R., Olsavsky, A. K., et al. Abnormal fusiform activation during emotional-face encoding assessed with functional magnetic resonance imaging. Psychiatry Res. 2013;212:161–3.
Adler, C. M., DelBello, M. P., Weber, W. A., et al. Neurochemical effects of quetiapine in patients with bipolar mania: a proton magnetic resonance spectroscopy study. J Clin Psychopharmacol. 2013;33: 528–32.
Alberts, B., Kirschner, M. W., Tilghman, S. et al. Rescuing US biomedical research from its systemic flaws. Proc Natl Acad Sci U S A. 2014;111:5773–7.
Alexander, G. E., DeLong, M. R., Strick, P. L. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci. 1986;9:357–81.
Almeida, J. R., Akkal, D., Hassel, S., et al. Reduced gray matter volume in ventral prefrontal cortex but not amygdala in bipolar disorder: significant effects of gender and trait anxiety. Psychiatry Res. 2009a;171:5468.
Almeida, J. R., Versace, A., Mechelli, A., et al. Abnormal amygdala-prefrontal effective connectivity to happy faces differentiates bipolar from major depression. Biol Psychiatry. 2009b;66:451–9.
Altshuler, L. L., Bartzokis, G., Grieder, T., et al. Amygdala enlargement in bipolar disorder and hippocampal reduction in schizophrenia: An MRI study demonstrating neuroanatomic specificity. Arch Gen Psychiatry. 1998;55:663–4.
Altshuler, L. L., Bartzokis, G., Grieder, T., et al. An MRI study of temporal lobe structures in men with bipolar disorder or schizophrenia. Biol Psychiatry 2000;48:147–62.
Altshuler, L. L., Bookheimer, S. Y., Townsend, J., et al. Blunted activation in orbitofrontal cortex during mania: a functional magnetic resonance imaging study. Biol Psychiatry. 2005;58:763–9.
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders: DSM-IV-TR. Washington, DC: Amercian Psychiatric Association, 2003.
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders: DSM-5. Arlington, VA: American Psychiatric Publishing; 2013.
Anand, A., Li, Y., Wang, Y., et al. Resting state corticolimbic connectivity abnormalities in unmedicated bipolar disorder and unipolar depression. Psychiatry Res. 2009;171:189–98.
Anticevic, A., Brumbaugh, M. S., Winkler, A. M., et al. Global prefrontal and fronto-amygdala dysconnectivity in bipolar I disorder with psychosis history. Biol Psychiatry. 2013;73:565–73.
Arts, B., Jabben, N., Krabbendam, L. et al. Meta-analyses of cognitive functioning in euthymic bipolar patients and their first-degree relatives. Psychol Med. 2008;38:771–85.
Baloch, H. A., Hatch, J. P., Olvera, R. L., et al. Morphology of the subgenual prefrontal cortex in pediatric bipolar disorder. J Psychiatr Res. 2010;44:1106–10.
Basso, M. R., Lowery, N., Neel, J., et al. Neuropsychological impairment among manic, depressed, and mixed- episode inpatients with bipolar disorder. Neuropsychology. 2002;16:8491.
Baxter, M. G. & Murray, E. A. The amygdala and reward. Nat Rev Neurosci. 2002;3:563–73.
Bearden, C. E., Hoffman, K. M. & Cannon, T. D. The neuropsychology and neuroanatomy of bipolar affective disorder: A critical review. Bipolar Disord. 2001;3:106–50.
Benedetti, F., Absinta, M., Rocca, M. A., et al. Tract-specific white matter structural disruption in patients with bipolar disorder. Bipolar Disord. 2011;13:414–24.
Biederman, J., Klein, R. G., Pine, D. S. et al. Resolved: mania is mistaken for ADHD in prepubertal children. J Am Acad Child Adolesc Psychiatry. 1998;37:1091–6; discussion 1096–9.
Biederman, J., Mick, E., Spencer, T. J., et al. Therapeutic dilemmas in the pharmacotherapy of bipolar depression in the young. J Child Adolesc Psychopharmacol. 2000;10: 185–92.
Birmaher, B., Axelson, D., Strober, M., et al. Clinical course of children and adolescents with bipolar spectrum disorders. Arch Gen Psychiatry. 2006;63:175–83.
Biswal, B. B. Resting state fMRI: a personal history. Neuroimage. 2012;62:938–44.
Bitter, S. M., Weber, W. A., Chu, W. J., et al. N-acetyl aspartate levels in adolescents with bipolar and/or cannabis use disorders. J Dual Diagn. 2014;10:3943.
Blond, B. N., Fredericks, C. A., Blumberg, H. P. Functional neuroanatomy of bipolar disorder: structure, function, and connectivity in an amygdala-anterior paralimbic neural system. Bipolar Disord. 2012;14:340–55.
Blumberg, H. P., Kaufman, J., Martin, A., et al. Amygdala and hippocampal volumes in adolescents and adults with bipolar disorder. Arch Gen Psychiatry. 2003a;60:1201–8.
Blumberg, H. P., Martin, A., Kaufman, J., et al. Frontostriatal abnormalities in adolescents with bipolar disorder: preliminary observations from functional MRI. Am J Psychiatry. 2003b;160:1345–7.
Blumberg, H. P., Donegan, N. H., Sanislow, C. A., et al. Preliminary evidence for medication effects on functional abnormalities in the amygdala and anterior cingulate in bipolar disorder. Psychopharmacology (Berl.) 2005a;183:308–13.
Blumberg, H. P., Fredericks, C., Wang, F., et al. Preliminary evidence for persistent abnormalities in amygdala volumes in adolescents and young adults with bipolar disorder. Bipolar Disord. 2005b;7:570–6.
Bora, E., Yucel, M., Pantelis, C. Cognitive endophenotypes of bipolar disorder: a meta-analysis of neuropsychological deficits in euthymic patients and their first-degree relatives. J Affect Disord. 2009;113:120.
Brambilla, P., Harenski, K., Nicoletti, M., et al. MRI investigation of temporal lobe structures in bipolar patients. J Psychiatr Res. 2003;37:287–95.
Brotman, M. A., Schmajuk, M., Rich, B. A., et al. Prevalence, clinical correlates, and longitudinal course of severe mood dysregulation in children. Biol Psychiatry. 2006;60:991–7.
Brotman, M. A., Kassem, L., Reising, M. M., et al. Parental diagnoses in youth with narrow phenotype bipolar disorder or severe mood dysregulation. Am J Psychiatry. 2007;164:1238–41.
Brotman, M. A., Guyer, A. E., Lawson, E. S. et al. Facial emotion labeling deficits in children and adolescents at risk for bipolar disorder. Am J Psychiatry. 2008a;165:385–9.
Brotman, M. A., Skup, M., Rich, B. A., et al. Risk for bipolar disorder is associated with face-processing deficits across emotions. J Am Acad Child Adolesc Psychiatry. 2008b;47:1455–61.
Brotman, M. A., Rich, B. A., Guyer, A. E., et al. Amygdala activation during emotion processing of neutral faces in children with severe mood dysregulation versus ADHD or bipolar disorder. Am J Psychiatry. 2010;167:61–9.
Brotman, M. A., Tseng, W. L., Olsavsky, A. K., et al. Fronto- limbic-striatal dysfunction in pediatric and adult patients with bipolar disorder: impact of face emotion and attentional demands. Psychol Med. 2013;113.
Bruckl, T. M., Wittchen, H. U., Hofler, M., et al. Childhood separation anxiety and the risk of subsequent psychopathology: Results from a community study. Psychother Psychosom. 2007;76:4756.
Cabeza, R., Nyberg, L. Imaging cognition II: An empirical review of 275 PET and fMRI studies. J Cogn Neurosci. 2000;12:147.
Carlson, G. A. Mania and ADHD: comorbidity or confusion. J Affect Disord. 1998;51:177–87.
Chaddock, C. A., Barker, G. J., Marshall, N., et al. White matter microstructural impairments and genetic liability to familial bipolar I disorder. Br J Psychiatry. 2009;194:527–34.
Chang, K., Adleman, N., Dienes, K., et al. Decreased N-acetylaspartate in children with familial bipolar disorder. Biol Psychiatry. 2003;53:1059–65.
Chang, K., Karchemskiy, A., Barnea-Goraly, N., et al. Reduced amygdalar gray matter volume in familial pediatric bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2005;44:565–73.
Chang, K., Delbello, M., Chu, W. J., et al. Neurometabolite effects of response to quetiapine and placebo in adolescents with bipolar depression. J Child Adolesc Psychopharmacol. 2012;22:261–8.
Chen, C. H., Suckling, J., Lennox, B. R., et al. A quantitative meta-analysis of fMRI studies in bipolar disorder. Bipolar Disord. 2011;13:115.
Chepenik, L. G., Raffo, M., Hampson, M., et al. Functional connectivity between ventral prefrontal cortex and amygdala at low frequency in the resting state in bipolar disorder. Psychiatry Res. 2010;182:207–10.
Chitty, K. M., Lagopoulos, J., Lee, R. S., et al. A systematic review and meta-analysis of proton magnetic resonance spectroscopy and mismatch negativity in bipolar disorder. Eur Neuropsychopharmacol. 2013;23:1348–63.
Clark, L., Goodwin, G. M. State- and trait-related deficits in sustained attention in bipolar disorder. Eur Arch Psychiatry Clin Neurosci. 2004;254:61–8.
Copeland, W. E., Angold, A., Costello, E. J. et al. Prevalence, comorbidity, and correlates of DSM-5 proposed disruptive mood dysregulation disorder. Am J Psychiatry. 2013;170:173–9.
Copeland, W. E., Shanahan, L., Egger, H., et al. Adult diagnostic and functional outcomes of DSM-5 disruptive mood dysregulation disorder. Am J Psychiatry. 2014;171:668–74.
Davanzo, P., Thomas, M. A., Yue, K., et al. Decreased anterior cingulate myo-inositol/creatine spectroscopy resonance with lithium treatment in children with bipolar disorder. Neuropsychopharmacology. 2001;24:359–69.
Davanzo, P., Yue, K., Thomas, M. A., et al. Proton magnetic resonance spectroscopy of bipolar disorder versus intermittent explosive disorder in children and adolescents. Am J Psychiatry. 2003;160:1442–52.
DelBello, M. P., Zimmerman, M. E., Mills, N. P., et al. Magnetic resonance imaging analysis of amygdala and other subcortical brain regions in adolescents with bipolar disorder. Bipolar Disord. 2004;6:4352.
Delvecchio, G., Fossati, P., Boyer, P., et al. Common and distinct neural correlates of emotional processing in bipolar disorder and major depressive disorder: a voxel-based meta-analysis of functional magnetic resonance imaging studies. Eur Neuropsychopharmacol. 2012;22:100–13.
Delvecchio, G., Sugranyes, G., Frangou, S. Evidence of diagnostic specificity in the neural correlates of facial affect processing in bipolar disorder and schizophrenia: a meta-analysis of functional imaging studies. Psychol Med. 2013;43:553–69.
Derntl, B., Seidel, E. M., Kryspin-Exner, I., et al. Facial emotion recognition in patients with bipolar I and bipolar II disorder. Br J Clin Psychol. 2009;48:363–75.
Deveney, C. M., Brotman, M. A., Decker, A. M., et al. Affective prosody labeling in youths with bipolar disorder or severe mood dysregulation. J Child Psychol Psychiatry. 2012a;53:262–70.
Deveney, C. M., Connolly, M. E., Jenkins, S. E., et al. Striatal dysfunction during failed motor inhibition in children at risk for bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2012b;38:127–33.
Deveney, C. M., Connolly, M. E., Jenkins, S. E., et al. Neural recruitment during failed motor inhibition differentiates youths with bipolar disorder and severe mood dysregulation. Biol Psychol. 2012c;89:148–55.
Dickstein, D. P., Treland, J. E., Snow, J., et al. Neuropsychological performance in pediatric bipolar disorder. Biol Psychiatry. 2004;55:32–9.
Dickstein, D. P., Milham, M. P., Nugent, A. C., et al. Frontotemporal alterations in pediatric bipolar disorder: Results of a voxel-based morphometry study. Arch Gen Psychiatry. 2005;62:734–41.
Dickstein, D. P., Nelson, E. E., McClure, E. B., et al. Cognitive flexibility in phenotypes of pediatric bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2007;46:341–55.
Dickstein, D. P., Finger, E. C., Brotman, M. A., et al. Impaired probabilistic reversal learning in youths with mood and anxiety disorders. Psychol Med. 2010a;40:1089–100.
Dickstein, D. P., Finger, E. C., Skup, M., et al. Altered neural function in pediatric bipolar disorder during reversal learning. Bipolar Disord. 2010b;12:707–19.
Dickstein, D. P., Gorrostieta, C., Ombao, H., et al. Fronto-temporal spontaneous resting state functional connectivity in pediatric bipolar disorder. Biol Psychiatry. 2010c;68:839–46.
Doyle, A. E., Wilens, T. E., Kwon, A., et al. Neuropsychological functioning in youth with bipolar disorder. Biol Psychiatry. 2005;58:540–8.
Eker, C., Simsek, F., Yilmazer, E. E., et al. Brain regions associated with risk and resistance for bipolar I disorder: a voxel-based MRI study of patients with bipolar disorder and their healthy siblings. Bipolar Disord. 2014;16:249–61.
Emsell, L., Chaddock, C., Forde, N., et al. White matter microstructural abnormalities in families multiply affected with bipolar I disorder: a diffusion tensor tractography study. Psychol Med. 2013;112.
Faedda, G. L., Baldessarini, R. J., Suppes, T., et al. Pediatric-onset bipolar disorder: A neglected clinicial and public health problem. Harvard Rev Psychiatry. 1995;3:171–95.
Favre, P., Baciu, M., Pichat, C., et al. fMRI evidence for abnormal resting-state functional connectivity in euthymic bipolar patients. J Affect Disord. 2014;165:182–9.
Fears, S. C., Service, S. K., Kremeyer, B., et al. Multisystem component phenotypes of bipolar disorder for genetic investigations of extended pedigrees. JAMA Psychiatry. 2014;71:375–87.
Foland-Ross, L. C., Bookheimer, S. Y., Lieberman, M. D., et al. Normal amygdala activation but deficient ventrolateral prefrontal activation in adults with bipolar disorder during euthymia. Neuroimage. 2012;59:738–44.
Frangou, S. Snipping at the endophenotypic space. Am J Psychiatry. 2013;170:1223–5.
Frazier, J. A., Breeze, J. L., Papadimitriou, G., et al. White matter abnormalities in children with and at risk for bipolar disorder. Bipolar Disord. 2007;9:799809.
Fu, C. H., Mourao-Miranda, J., Costafreda, S. G., et al. Pattern classification of sad facial processing: toward the development of neurobiological markers in depression. Biol Psychiatry. 2008;63:656–62.
Garrett, A. S., Reiss, A. L., Howe, M. E., et al. Abnormal amygdala and prefrontal cortex activation to facial expressions in pediatric bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2012;51:821–31.
Geller, B., Fox, L. W. & Clark, K. A. Rate and predictors of prepubertal bipolarity during follow-up of 6- to 12-year-old depressed children. J Am Acad Child Adolesc Psychiatry. 1994;33:461–8.
Giedd, J. N., Blumenthal, J., Jeffries, N. O., et al. Brain development during childhood and adolescence: a longitudinal MRI study. Nat Neurosci. 1999;2:861–3.
Gigante, A. D., Bond, D. J., Lafer, B., et al. Brain glutamate levels measured by magnetic resonance spectroscopy in patients with bipolar disorder: a meta-analysis. Bipolar Disord. 2012;14:478–87.
Glahn, D. C., Bearden, C. E., Niendam, T. A. et al. The feasibility of neuropsychological endophenotypes in the search for genes associated with bipolar affective disorder. Bipolar Disord. 2004;6:171–82.
Glahn, D. C., Almasy, L., Barguil, M., et al. Neurocognitive endophenotypes for bipolar disorder identified in multiplex multigenerational families. Arch Gen Psychiatry. 2010;67:168–77.
Gorrindo, T., Blair, R. J., Budhani, S., et al. Deficits on a probabilistic response-reversal task in patients with pediatric bipolar disorder. Am J Psychiatry. 2005;162:1975–7.
Gottesman, II, Gould, T. D. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry. 2003;160:636–45.
Gottfried, J. A., O’Doherty, J., Dolan, R. J. Encoding predictive reward value in human amygdala and orbitofrontal cortex. Science. 2003;301:1104–7.
Guyer, A. E., McClure, E. B., Adler, A. D., et al. Specificity of facial expression labeling deficits in childhood psychopathology. J Child Psychol Psychiatry. 2007;48:863–71.
Hajek, T., Alda, M., Hajek, E. et al. Functional neuroanatomy of response inhibition in bipolar disorders – combined voxel based and cognitive performance meta-analysis. J Psychiatr Res. 2013a;47:1955–66.
Hajek, T., Cullis, J., Novak, T., et al. Brain structural signature of familial predisposition for bipolar disorder: replicable evidence for involvement of the right inferior frontal gyrus. Biol Psychiatry. 2013b;73:144–52.
Haller, S., Xekardaki, A., Delaloye, C., et al. Combined analysis of grey matter voxel-based morphometry and white matter tract-based spatial statistics in late-life bipolar disorder. J Psychiatry Neurosci. 2011;36:391401.
Hariri, A. R., Drabant, E. M., Munoz, K. E., et al. A susceptibility gene for affective disorders and the response of the human amygdala. Arch Gen Psychiatry. 2005;62:146–52.
Houenou, J., Frommberger, J., Carde, S., et al. Neuroimaging-based markers of bipolar disorder: evidence from two meta-analyses. J Affect Disord. 2011;132:344–55.
Insel, T. R. Mental disorders in childhood: shifting the focus from behavioral symptoms to neurodevelopmental trajectories. JAMA. 2014a;311:1727–8.
Insel, T. R. The NIMH Research Domain Criteria (RDoC) Project: precision medicine for psychiatry. Am J Psychiatry. 2014b;171:395–7.
Insel, T., Cuthbert, B., Garvey, M., et al. Research domain criteria (RDoC): toward a new classification framework for research on mental disorders. Am J Psychiatry. 2010;167:748–51.
Iverson, G. L., Brooks, B. L., Young, A. H. Rapid computerized assessment of neurocognitive deficits in bipolar disorder. Appl Neuropsychol. 2009;16:207–13.
Izquierdo, A., Murray, E. A. Combined unilateral lesions of the amygdala and orbital prefrontal cortex impair affective processing in rhesus monkeys. J Neurophysiol. 2004;91:2023–39.
Johnson, J. G., Cohen, P., Brook, J. S. Associations between bipolar disorder and other psychiatric disorders during adolescence and early adulthood: a community-based longitudinal investigation. Am J Psychiatry. 2000;157:1679–81.
Kalmar, J. H., Wang, F., Chepenik, L. G., et al. Relation between amygdala structure and function in adolescents with bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2009;48:636–42.
Kaur, S., Sassi, R. B., Axelson, D., et al. Cingulate cortex anatomical abnormalities in children and adolescents with bipolar disorder. Am J Psychiatry. 2005;162:1637–43.
Keener, M. T., Fournier, J. C., Mullin, B. C., et al. Dissociable patterns of medial prefrontal and amygdala activity to face identity versus emotion in bipolar disorder. Psychol Med. 2012;42:1913–24.
Kim, P., Jenkins, S. E., Connolly, M. E., et al. Neural correlates of cognitive flexibility in children at risk for bipolar disorder. J Psychiatr Res. 2012a;46:2230.
Kim, P., Thomas, L. A., Rosen, B. H., et al. Differing amygdala responses to facial expressions in children and adults with bipolar disorder. Am J Psychiatry. 2012b;169:642–9.
Kim-Cohen, J., Caspi, A., Moffitt, T. E., et al. Prior juvenile diagnoses in adults with mental disorder: developmental follow-back of a prospective-longitudinal cohort. Arch Gen Psychiatry. 2003;60:709–17.
Kimura, M., Yamada, H., Matsumoto, N. Tonically active neurons in the striatum encode motivational contexts of action. Brain Devel. 2003;25(Suppl 1):S20–3.
Kohler, C. G., Hoffman, L. J., Eastman, L. B., et al. Facial emotion perception in depression and bipolar disorder: a quantitative review. Psychiatry Res. 2011;188:303–9.
Kupferschmidt, D. A., Zakzanis, K. K. Toward a functional neuroanatomical signature of bipolar disorder: quantitative evidence from the neuroimaging literature. Psychiatry Res. 2011;193:71–9.
Ladouceur, C. D., Farchione, T., Diwadkar, V., et al. Differential patterns of abnormal activity and connectivity in the amygdala-prefrontal circuitry in bipolar-I and bipolar-NOS youth. J Am Acad Child Adolesc Psychiatry. 2011;50:1275–89 e2.
Lawrence, N. S., Williams, A. M., Surguladze, S., et al. Subcortical and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar disorder and major depression. Biol Psychiatry. 2004;55:578–87.
Leibenluft, E. Severe mood dysregulation, irritability, and the diagnostic boundaries of bipolar disorder in youths. Am J Psychiatry. 2011;168:129–42.
Leibenluft, E. Categories and dimensions, brain and behavior: the yins and yangs of psychopathology. JAMA Psychiatry. 2014;71:1517.
Leibenluft, E., Charney, D. S., Towbin, K. E., et al. Defining clinical phenotypes of juvenile mania. Am J Psychiatry. 2003;160:430–7.
Leibenluft, E., Rich, B. A., Vinton, D. T., et al. Neural circuitry engaged during unsuccessful motor inhibition in pediatric bipolar disorder. Am J Psychiatry. 2007;164:5260.
Lembke, A., Ketter, T. A. mpaired recognition of facial emotion in mania. Am J Psychiatry. 2002;159:302–4.
Lewinsohn, P. M., Klein, D. N., Seeley, J. R. Bipolar disorders in a community sample of older adolescents: Prevalence, phenomenology, comorbidity, and course. J Am Acad Child Adolesc Psychiatry. 1995;34:454–63.
Lewinsohn, P. M., Klein, D. N., Seeley, J. R. Bipolar disorder during adolescence and young adulthood in a community sample. Bipolar Disord. 2000;2:281–93.
Lewinsohn, P. M., Seeley, J. R., Klein, D. N. Bipolar disorders during adolescence. Acta Psychiatr Scand. 2003;108:4750.
Lieberman, M. D., Berkman, E. T., Wager, T. D. Correlations in social neuroscience aren’t voodoo. Perspect Psychol Sci. 2009;4:299307.
Linke, J., King, A. V., Rietschel, M., et al. Increased medial orbitofrontal and amygdala activation: evidence for a systems-level endophenotype of bipolar I disorder. Am J Psychiatry. 2012;169:316–25.
Linke, J., King, A. V., Poupon, C., et al. Impaired anatomical connectivity and related executive functions: differentiating vulnerability and disease marker in bipolar disorder. Biol Psychiatry. 2013;74:908–16.
Liu, I. Y., Howe, M., Garrett, A., et al. Striatal volumes in pediatric bipolar patients with and without comorbid ADHD. Psychiatry Res. 2011;194:1420.
Lopez-Larson, M., Michael, E. S., Terry, J. E., et al. Subcortical differences among youths with attention-deficit/hyperactivity disorder compared to those with bipolar disorder with and without attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol. 2009;19:31–9.
Lyoo, I. K., Kim, M. J., Stoll, A. L., et al. Frontal lobe gray matter density decreases in bipolar I disorder. Biol Psychiatry. 2004;55:648–51.
Mahon, K., Burdick, K. E., Ikuta, T., et al. Abnormal temporal lobe white matter as a biomarker for genetic risk of bipolar disorder. Biol Psychiatry. 2013;73:177–82.
Martinez-Aran, A., Vieta, E., Reinares, M., et al. Cognitive function across manic or hypomanic, depressed, and euthymic states in bipolar disorder. Am J Psychiatry. 2004;161:262–70.
McClure, E. B., Pope, K., Hoberman, A. J., et al. Facial expression recognition in adolescents with mood and anxiety disorders. Am J Psychiatry. 2003;160:1172–4.
McClure, E. B., Treland, J. E., Snow, J., et al. Memory and learning in pediatric bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2005a;44:461–9.
McClure, E. B., Treland, J. E., Snow, J., et al. Deficits in social cognition and response flexibility in pediatric bipolar disorder. Am J Psychiatry. 2005b;162:1644–51.
McIntosh, A. M., Job, D. E., Moorhead, T. W., et al. White matter density in patients with schizophrenia, bipolar disorder and their unaffected relatives. Biol Psychiatry. 2005;58:254–7.
McIntosh, A. M., Munoz Maniega, S., Lymer, G. K., et al. White matter tractography in bipolar disorder and schizophrenia. Biol Psychiatry. 2008;64:1088–92.
Merikangas, K. R., Cui, L., Kattan, G., et al. Mania with and without depression in a community sample of US adolescents. Arch Gen Psychiatry. 2012;69:943–51.
Miller, E. K., Cohen, J. D. An integrative theory of prefrontal cortex function. Annu Rev Neurosci. 2001;24:167202.
Mourao-Miranda, J., Almeida, J. R., Hassel, S., et al. Pattern recognition analyses of brain activation elicited by happy and neutral faces in unipolar and bipolar depression. Bipolar Disord. 2012a;14:451–60.
Mourao-Miranda, J., Oliveira, L., Ladouceur, C. D., et al. Pattern recognition and functional neuroimaging help to discriminate healthy adolescents at risk for mood disorders from low risk adolescents. PLoS One. 2012b;7:e29482.
Murphy, F. C., Sahakian, B. J. Neuropsychology of bipolar disorder. Br J Psychiatry. 2001;178 :s120–7.
Nortje, G., Stein, D. J., Radua, J., et al. Systematic review and voxel-based meta-analysis of diffusion tensor imaging studies in bipolar disorder. J Affect Disord. 2013;150:192200.
Nowicki, S., Duke, M. Individual differences in the nonverbal communication of affect: The Diagnostic Analysis of Nonverbal Accuracy Scale. J Nonverbal Behav. 1994;18:935.
O’Doherty, J., Dayan, P., Schultz, J., et al. Dissociable roles of ventral and dorsal striatum in instrumental conditioning. Science. 2004;304:452–4.
Oertel-Knochel, V., Reinke, B., Alves, G., et al. Frontal white matter alterations are associated with executive cognitive function in euthymic bipolar patients. J Affect Disord. 2014;155:223–33.
Olsavsky, A. K., Brotman, M. A., Rutenberg, J. G., et al. Amygdala hyperactivation during face emotion processing in unaffected youth at risk for bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2012;51:294303.
Passarotti, A. M., Sweeney, J. A., Pavuluri, M. N. Neural correlates of response inhibition in pediatric bipolar disorder and attention deficit hyperactivity disorder. Psychiatry Res. 2010;181:3643.
Pasupathy, A., Miller, E. K. Different time courses of learning-related activity in the prefrontal cortex and striatum. Nature. 2005;433:873–6.
Patel, N. C., DelBello, M. P., Cecil, K. M., et al. Temporal change in N-acetyl-aspartate concentrations in adolescents with bipolar depression treated with lithium. J Child Adolesc Psychopharmacol. 2008;18:132–9.
Pavuluri, M. N., Passarotti, A. Neural bases of emotional processing in pediatric bipolar disorder. Expert Rev Neurother. 2008;8:1381–7.
Pavuluri, M. N., O’Connor, M. M., Harral, E. et al. Affective neural circuitry during facial emotion processing in pediatric bipolar disorder. Biol Psychiatry. 2007;62:158–67.
Pavuluri, M. N., Passarotti, A. M., Harral, E. M. et al. An fMRI study of the neural correlates of incidental versus directed emotion processing in pediatric bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2009a;48:308–19.
Pavuluri, M. N., Yang, S., Kamineni, K., et al. Diffusion tensor imaging study of white matter fiber tracts in pediatric bipolar disorder and attention-deficit/hyperactivity disorder. Biol Psychiatry. 2009b;65:586–93.
Pavuluri, M. N., Passarotti, A. M., Harral, E. M. et al. Enhanced prefrontal function with pharmacotherapy on a response inhibition task in adolescent bipolar disorder. J Clin Psychiatry. 2010;71:1526–34.
Pearlson, G. D., Barta, P. E., Powers, R. E., et al. Medial and superior temporal gyral volumes and cerebral asymmetry in schizophrenia versus bipolar disorder. Biol Psychiatry. 1997;41:114.
Pereira, F., Mitchell, T., Botvinick, M. Machine learning classifiers and fMRI: a tutorial overview. Neuroimage, 2009;45:S199–209.
Pfeifer, J. C., Welge, J., Strakowski, S. M., et al. Meta-analysis of amygdala volumes in children and adolescents with bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2008;47:1289–98.
Phillips, M. L., Swartz, H. A. A critical appraisal of neuroimaging studies of bipolar disorder: toward a new conceptualization of underlying neural circuitry and a road map for future research. Am J Psychiatry. 2014;171(8):829–43.
Phillips, M. L., Drevets, W. C., Rauch, S. L. et al. Neurobiology of emotion perception II: Implications for major psychiatric disorders. Biol Psychiatry. 2003;54:515–28.
Poldrack, R. A., Mumford, J. A. Independence in ROI analysis: where is the voodoo? Soc Cogn Affect Neurosci. 2009;4:208–13.
Posner, M. I., Rothbart, M. K. Attention, self-regulation and consciousness. Philos Transact R Soc Lond. Ser B, Biol Sci. 1998;353:1915–27.
Quirk, G. J., Beer, J. S. Prefrontal involvement in the regulation of emotion: convergence of rat and human studies. Curr Opin Neurobiol. 2006;16:723–7.
Rich, B. A., Vinton, D. T., Roberson-Nay, R., et al. Limbic hyperactivation during processing of neutral facial expressions in children with bipolar disorder. Proc Natl Acad Sci U S A. 2006;103:8900–5.
Rich, B. A., Grimley, M. E., Schmajuk, M., et al. Face emotion labeling deficits in children with bipolar disorder and severe mood dysregulation. Dev Psychopathol. 2008;20:529–46.
Rolls, E. T. Neurophysiology and cognitive functions of the striatum 1. Rev Neurol (Paris). 1994;150:648–60.
Rubinsztein, J. S., Michael, A., Paykel, E. S. et al. Cognitive impairment in remission in bipolar affective disorder. Psychol Med. 2000;30:1025–36.
Sarrazin, S., Poupon, C., Linke, J., et al. A multicenter tractography study of deep white matter tracts in bipolar I disorder: psychotic features and interhemispheric disconnectivity. JAMA Psychiatry. 2014;71:388–96.
Savitz, J., Solms, M., Ramesar, R. Neuropsychological dysfunction in bipolar affective disorder: a critical opinion. Bipolar Disord. 2005;7:216–35.
Sax, K. W., Strakowski, S. M., McElroy, S. L., et al. Attention and formal thought disorder in mixed and and pure mania. Biol Psychiatry. 1995;37:420–3.
Sax, K. W., Strakowski, S. M., Zimmerman, M. E., et al. Frontosubcortical neuroanatomy and the continuous performance test in mania. Am J Psychiatry. 1999;156:139–41.
Schaefer, K. L., Baumann, J., Rich, B. A., et al. Perception of facial emotion in adults with bipolar or unipolar depression and controls. J Psychiatr Res. 2010;44:1229–35.
Schenkel, L. S., Pavuluri, M. N., Herbener, E. S., et al. Facial emotion processing in acutely ill and euthymic patients with pediatric bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2007;46:1070–9.
Schenkel, L. S., Marlow-O’Connor, M., Moss, M., et al. Theory of mind and social inference in children and adolescents with bipolar disorder. Psychol Med. 2008;38:791800.
Scherk, H., Kemmer, C., Usher, J., et al. No change to grey and white matter volumes in bipolar I disorder patients. Eur Arch Psychiatry Clin Neurosci. 2008;258:345–9.
Schultz, W., Tremblay, L., Hollerman, J. R. Reward processing in primate orbiotfrontal cortex and basal ganglia. Cerebral Cotex. 2000;10:272–84.
Selvaraj, S., Arnone, D., Job, D., et al. Grey matter differences in bipolar disorder: a meta-analysis of voxel-based morphometry studies. Bipolar Disord. 2012;14:135–45.
Seymour, K. E., Pescosolido, M. F., Reidy, B. L., et al. Emotional face identification in youths with primary bipolar disorder or primary attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2013;52:537–46 e3.
Singh, M. K., Chang, K. D., Mazaika, P., et al. Neural correlates of response inhibition in pediatric bipolar disorder. J Child Adolesc Psychopharmacol. 2010;20:1524.
Singh, M. K., Chang, K. D., Chen, M. C., et al. Volumetric reductions in the subgenual anterior cingulate cortex in adolescents with bipolar I disorder. Bipolar Disord. 2012;14:585–96.
Singh, M. K., Jo, B., Adleman, N. E., et al. Prospective neurochemical characterization of child offspring of parents with bipolar disorder. Psychiatry Res. 2013;214:153–60.
Spencer, T. J., Biederman, J., Wozniak, J., et al. Parsing pediatric bipolar disorder from its associated comorbidity with the disruptive behavior disorders. Biol Psychiatry. 2001;49:1062–70.
Strakowski, S. M., DelBello, M. P., Sax, K. W., et al. Brain magnetic resonance imaging of structural abnormalities in bipolar disorder. Arch Gen Psychiatry. 1999;56:254–60.
Strakowski, S. M., Adler, C. M., Almeida, J., et al. The functional neuroanatomy of bipolar disorder: a consensus model. Bipolar Disord. 2012;14:313–25.
Stringaris, A. Irritability in children and adolescents: a challenge for DSM-5. Eur Child Adolesc Psychiatry. 2011;20:61–6.
Stringaris, A., Goodman, R. Longitudinal outcome of youth oppositionality: irritable, headstrong, and hurtful behaviors have distinctive predictions. J Am Acad Child Adolesc Psychiatry. 2009;48:404–12.
Stringaris, A., Cohen, P., Pine, D. S. et al. Adult outcomes of youth irritability: a 20-year prospective community-based study. Am J Psychiatry. 2009;166:1048–54.
Stringaris, A., Baroni, A., Haimm, C., et al. Pediatric bipolar disorder versus severe mood dysregulation: risk for manic episodes on follow-up. J Am Acad Child Adolesc Psychiatry. 2010;49:397405.
Surguladze, S. A., Marshall, N., Schulze, K., et al. Exaggerated neural response to emotional faces in patients with bipolar disorder and their first-degree relatives. Neuroimage. 2010;53:5864.
Teng, S., Lu, C. F., Wang, P. S., et al. Altered resting-state functional connectivity of striatal-thalamic circuit in bipolar disorder. PLoS One. 2014;9:e96422.
Thomas, L. A., Brotman, M. A., Muhrer, E. J., et al. Parametric modulation of neural activity by emotion in youth with bipolar disorder, youth with severe mood dysregulation, and healthy volunteers. Arch Gen Psychiatry. 2012;69:1257–66.
Thomas, L. A., Kim, P., Bones, B. L., et al. Elevated amygdala responses to emotional faces in youths with chronic irritability or bipolar disorder. Neuroimage Clin. 2013;2:637–45.
Torrisi, S., Moody, T. D., Vizueta, N., et al. Differences in resting corticolimbic functional connectivity in bipolar I euthymia. Bipolar Disord. 2013;15:156–66.
Townsend, J. D., Torrisi, S. J., Lieberman, M. D., et al. Frontal-amygdala connectivity alterations during emotion downregulation in bipolar I disorder. Biol Psychiatry. 2013;73:127–35.
Tseng, W.-L., Bones, B. L., Kayser, R. R., et al. An fMRI study of emotional face encoding in youth at risk for bipolar disorder. Eur Psychiatry. 2015;30(1):94–8.
Van Meter, A. R., Moreira, A. L., Youngstrom, E. A. Meta-analysis of epidemiologic studies of pediatric bipolar disorder. J Clin Psychiatry. 2011;72:1250–6.
Van Rheenen, T. E., Rossell, S. L. Is the non-verbal behavioural emotion-processing profile of bipolar disorder impaired? A critical review. Acta Psychiatr Scand. 2013;128:163–78.
Van Rheenen, T. E., Rossell, S. L. Let’s face it: facial emotion processing is impaired in bipolar disorder. J Int Neuropsychol Soc. 2014;20:200–8.
Vederine, F. E., Wessa, M., Leboyer, M. et al. A meta-analysis of whole-brain diffusion tensor imaging studies in bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2011;35:1820–6.
Versace, A., Almeida, J. R., Hassel, S., et al. Elevated left and reduced right orbitomedial prefrontal fractional anisotropy in adults with bipolar disorder revealed by tract-based spatial statistics. Arch Gen Psychiatry. 2008;65:1041–52.
Vul, E., Harris, C., Winkielman, P. et al. Puzzlingly high correlations in fMRI studies of emotion, personality, and social cognition. Perspect Psychol Sci. 2009;4:274–90.
Weathers, J. D., Stringaris, A., Deveney, C. M., et al. A developmental study of the neural circuitry mediating motor inhibition in bipolar disorder. Am J Psychiatry. 2012;169:633–41.
Weathers, J., Brotman, M. A., Deveney, C. M., et al. A developmental study on the neural circuitry mediating response flexibility in bipolar disorder. Psychiatry Res. 2013;214:5665.
Wegbreit, E., Cushman, G. K., Puzia, M. E., et al. Developmental meta-analyses of the functional neural correlates of bipolar disorder. JAMA Psychiatry. 2014;71(8):926–35.
Weller, E., Weller, R. A., Dogin, J. W. A rose is a rose is a rose. J Affect Disord. 1998;51:189–95.
Whitney, J., Howe, M., Shoemaker, V., et al. Socio-emotional processing and functioning of youth at high risk for bipolar disorder. J Affect Disord. 2013;148:112–17.
Wilder-Willis, K. E., Sax, K. W., Rosenberg, H. L., et al. Persistent attentional dysfunction in remitted bipolar disorder. Bipolar Disord. 2001;3:5862.
Wilke, M., Kowatch, R. A., DelBello, M. P., et al. Voxel-based morphometry in adolescents with bipolar disorder: first results. Psychiatry Res. 2004;131:5769.
Winsberg, M. E., Sachs, N., Tate, D. L., et al. Decreased dorsolateral prefrontal N-acetyl aspartate in bipolar disorder. Biol Psychiatry. 2000;47:475–81.
Wozniak, J., Biederman, J., Kiely, K et al. Mania-like symptoms suggestive of childhood-onset bipolar disorder in clinically referred children. J Am Acad Child Adolesc Psychiatry. 1995;34:867–76.
Wu, M., Lu, L. H., Passarotti, A. M., et al. Altered affective, executive and sensorimotor resting state networks in patients with pediatric mania. J Psychiatry Neurosci. 2013;38:232–40.
Zink, C. F., Pagnoni, G., Martin-Skurski, M. E., et al. Human striatal responses to monetary reward depend on saliency. Neuron. 2004;42:509–17.