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  1. Home
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  3. Bioinformatics for Biologists
  • Cited by 5
Publisher:
Cambridge University Press
Online publication date:
June 2012
Print publication year:
2011
Online ISBN:
9780511984570
DOI:
https://doi.org/10.1017/CBO9780511984570
Subjects:
Genomics, Bioinformatics and Systems Biology, Life Sciences, Computer Science, Computational Biology and Bioinformatics
Information

Book description

The computational education of biologists is changing to prepare students for facing the complex datasets of today's life science research. In this concise textbook, the authors' fresh pedagogical approaches lead biology students from first principles towards computational thinking. A team of renowned bioinformaticians take innovative routes to introduce computational ideas in the context of real biological problems. Intuitive explanations promote deep understanding, using little mathematical formalism. Self-contained chapters show how computational procedures are developed and applied to central topics in bioinformatics and genomics, such as the genetic basis of disease, genome evolution or the tree of life concept. Using bioinformatic resources requires a basic understanding of what bioinformatics is and what it can do. Rather than just presenting tools, the authors - each a leading scientist - engage the students' problem-solving skills, preparing them to meet the computational challenges of their life science careers.

Reviews

'This volume contains a remarkable collection of individually-authored chapters cutting a wide swathe across the field as it is currently constituted. What is noteworthy, aside from the wide angle of the snapshot of today's bioinformatics, something the editors promise to update in future editions, is the innovative and effective pedagogical emphasis apparent throughout … The editors set out to provide a resource for teaching bioinformatics to life science undergraduates, and this is reflected in the language, organization and mathematical restraint of the different chapters … It is highly suitable as a text or reference for bioinformatics courses at the graduate level, for biologists, medical students and computer scientists. Biological naïveté in thinking and writing plagues bioinformatics, and Pevzner and Shamir's Bioinformatics for Biologists offers a wonderful therapy for that condition as well as an effective palliative for life science students' math phobias.'

Professor David Sankoff - University of Ottawa

'A serious and valuable effort to bring essential and much-needed training in the computational sciences to students of modern biology.'

Michael Waterman - University of Southern California

'This volume represents an excellent [effort] towards creating an interesting and useful introductory bioinformatics text. In its current form it may benefit computational scientists more than biologists, but has the potential to evolve into an invaluable resource for all bioinformaticists, independent of their primary field of study.'

Dimitris Papamichail Source: SIGACT News

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Contents

Page 1 of 2

Contents

Page 1 of 2

References
REFERENCES
References
[1] N., Guelzim, S., Bottani, P., Bourgine, and F., Képès. Topological and causal structure of the yeast transcriptional regulatory network. Nature Genet., 31:60–63, 2002.
[2] National Human Genome Research Institute. Image provided for free public use through the US National Institutes of Health Image Bank as NHGRI press gallery photo 20018.
[3] M. B., Eisen, P. T., Spellman, P. O., Brown, and D., Botstein. Cluster analysis and display of genome-wide expression patterns. Proc. Natl. Acad. Sci. U S A, 95:14, 863–14, 868, 1998.
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[15] R. E., Neapolitan. Learning Bayesian Networks. Pearson Prentice Hall, Upper Saddle River, NJ, 2004.
[16] W. R., Gilks, S., Richardson, and D. J., Spiegelhalter. Markov Chain Monte Carlo in Practice. Chapman and Hall/CRC, Boca Raton, FL, 1996.
[17] A., Ruszczyński. Nonlinear Optimization. Princeton University Press, Princeton, NJ, 2006.
[18] S., Boyd and L., Vandenberghe. Convex Optimization. Cambridge University Press, New York, 2004.
[19] P., Dhaseleer, S., Liang, and R., Somogyi. Genetic network inference: From co-expression clustering to reverse engineering. Bioinformatics, 16:707–726, 2000.
[20] N., Friedman, M., Linial, I., Nachman, and D., Pe'er. Using Bayesian networks to analyze expression data. J. Comp. Biol., 7:601–620, 2000.

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