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  • Print publication year: 2016
  • Online publication date: January 2017

Chapter 14 - Management of the Third Stage of Labour

1.AbouZahr, C. Global burden of maternal death and disability. In Rodeck, C (ed.), Reducing Maternal Death and Disability in Pregnancy (pp. 111). Oxford: Oxford University Press; 2003.
2.Khan, KS, Wojdyla, D, Say, L, Gümezoglu, AM, Look, PFA. WHO analysis of causes of maternal death: a systematic review. Lancet. 2006; 367: 1066–74.
3.Knight, M, Kenyon, S, Brocklehurst, P, et al. (eds). Saving Lives, Improving Mothers’ Care: Lessons Learned to Inform Future Maternity Care from the UK and Ireland Confidential Enquiries into Maternal Deaths and Morbidity 2009–12. Oxford: National Perinatal Epidemiology Unit, University of Oxford; 2014.
4.World Health Organization. Maternal Mortality in 2005. Geneva: WHO; 2007.
5.Magann, EF, Evans, S, Chauhan, SP, et al. The length of the third stage of labor and the risk of postpartum hemorrhage. Obstet Gynecol. 2005; 105: 290–3.
6.NICE. Intrapartum Care: Care of Healthy Women and their Babies during Childbirth: Clinical Guideline 190. London: NICE; 2014.
7.World Health Organization. WHO Recommendations for the Prevention and Treatment of Postpartum Haemorrhage: Geneva: WHO; 2013.
8.Liabsuetrakul, T, Choobun, T, Peeyananjarassri, K, Islam, QM. Prophylactic use of ergot alkaloids in the third stage of labour. Cochrane Database Syst Rev. 2007; 2: CD005456.
9.McDonald, S, Abbott, JM, Higgins, SP. Prophylactic ergometrine–oxytocin versus oxytocin for the third stage of labour. Cochrane Database Syst Rev. 2004; 1: CD000201.
10.Attilakos, G, Psaroudakis, D, Ash, J, et al. Carbetocin versus oxytocin for the prevention of postpartum haemorrhage following caesarean section: the results of a double-blind randomised trial. BJOG. 2010; 117: 929–36.
11.Su, LL, Chong, YS, Samuel, M. Oxytocin agonists for preventing postpartum haemorrhage. Cochrane Database Syst Rev. 2007; 3: CD005457.
12.Abalos, E. Choice of uterotonic agents in the active management of the third stage of labour: RHL commentary. Geneva: World Health Organization; 2009.
13.Gulmezoglu, AM, Forna, F, Villar, J, Hofmeyr, GJ. Prostaglandins for preventing postpartum haemorrhage. Cochrane Database Syst Rev. 2007; 3: CD000494.
14.Khan, RU, El-Refaey, H. Pharmacokinetics and adverse-effect profile of rectally administered misoprostol in the third stage of labor. Obstet Gynecol. 2003; 101: 968–74.
15.Bai, Jing, Sun, Qian, Zhai, Hui. A comparison of oxytocin and carboprost tromethamine in the prevention of postpartum hemorrhage in high-risk patients undergoing cesarean delivery. Exp Ther Med. 2014; 7(1): 4650.
16.Vaid, A, Dadhwal, V, Mittal, S, et al. A randomized controlled trial of prophylactic sublingual misoprostol versus intramuscular methyl-ergometrine versus intramuscular 15-methyl PGF2alpha in active management of third stage of labor. Arch Gynecol Obstet. 2009; 280: 893–7.
17.Habek, D, Franicevic, D. Intraumbilical injection of uterotonics for retained placenta. Int J Gynaecol Obstet. 2007; 99: 105–9.
18.Ghulmiyyah, LM, Wehbe, SA, Saltzman, SL, Ehleben, C, Sibai, BM. Intraumbilical vein injection of oxytocin and the third stage of labor: randomized double-blind placebo trial. Am J Perinatol. 2007; 24: 347–52.
19.Nardin, JM, Weeks, A, Carroli, G. Umbilical vein injection for management of retained placenta. Cochrane Database Syst Rev. 2011; 5: CD001337.
20.Andersson, O, Hellström-Westas, L, Andersson, D, Domellöf, M. Effect of delayed versus early umbilical cord clamping on neonatal outcomes and iron status at 4 months: a randomised controlled trial. BMJ. 2011; 343: d7156.
21.Strauss, RG, Mock, DM, Johnson, KJ, et al. A randomized clinical trial comparing immediate versus delayed clamping of the umbilical cord in preterm infants: short-term clinical and laboratory endpoints. Transfusion. 2008;48: 658–65.
22.Kaempf, JW, Tomlinson, MW, Kaempf, AJ, et al. Delayed umbilical cord clamping in premature neonates. Obstet Gynecol. 2012; 120: 325–30.
23.Sommers, R, Stonestreet, BS, Oh, W, et al. Hemodynamic effects of delayed cord clamping in premature infants. Pediatrics. 2012; 129: e667–72.
24.Takami, T, Suganami, Y, Sunohara, D, et al. Umbilical cord milking stabilizes cerebral oxygenation and perfusion in infants born before 29 weeks of gestation. J Pediatr. 2012; 161: 742–7.
25.Ibrahim, HM, Krouskop, RW, Lewis, DF, Dhanireddy, R. Placental transfusion: umbilical cord clamping and preterm infants. J Perinatol. 2000; 20: 351–4.
26.Kinmond, S, Aitchison, TC, Holland, BM, et al. Umbilical cord clamping and preterm infants: a randomised trial. BMJ. 1993; 306: 172–5.
27.Rabe, H, Diaz-Rossello, JL, Duley, L, Dowswell, T. Effect of timing of umbilical cord clamping and other strategies to influence placental transfusion at preterm birth on maternal and infant outcomes. Cochrane Database Syst Rev. 2012, 8: CD003248. doi: 10.1002/14651858.CD003248.pub3.
28.Aziz, K, Chinnery, H, Lacaze-Masmonteil, T. A single-center experience of implementing delayed cord clamping in babies born at less than 33 weeks’ gestational age. Adv Neonatal Care. 2012; 12: 371–6.
29.Mercer, JS, Vohr, BR, McGrath, MM, et al. Delayed cord clamping in very preterm infants reduces the incidence of intraventricular hemorrhage and late-onset sepsis: a randomized, controlled trial. Pediatrics. 2006; 117: 1235–42.
30.American College of Obstetricians and Gynecologists. Timing of umbilical cord clamping after birth: committee opinion no. 543. Obstet Gynecol. 2012; 120: 1522–6.
31.Saigal, S, O'Neill, A, Surainder, Y, Chua, LB, Usher, R. Placental transfusion and hyperbilirubinemia in the premature. Pediatrics. 1972; 49: 406–19.
32.Saigal, S, Usher, RH. Symptomatic neonatal plethora. Biol Neonate. 1977; 32: 6272.
33.Yao, AC, Lind, J, Vuorenkoski, V. Expiratory grunting in the late clamped normal neonate. Pediatrics. 1971; 48: 865–70.
34.Backes, CH, Rivera, BK, Haque, U, et al. Placental transfusion strategies in very preterm neonates. Obstet Gynecol. 2014; 124: 4756.
35.Royal College of Obstetricians and Gynaecologists. Clamping of the Umbilical Cord and Placental Transfusion. Scientific Impact Paper No. 14, 2015.
36.Pena-Marti, G, Comunian-Carrasco, G. Fundal pressure versus controlled cord traction as part of the active management of the third stage of labour. Cochrane Database Syst Rev. 2007; 4: CD005462.
37.Gulmezoglu, AM, Lumbiganon, P, Landoulsi, S, et al. Active management of the third stage of labour with and without controlled cord traction. Lancet. 2012; 379: 1721–7.
38.Tantbirojn, P, Crum, CP, Parast, MM. Pathophysiology of placenta creta: the role of decidua and extra villous trophoblast. Placenta. 2008; 29: 639–45.
39.RCOG. Placenta Praevia and Placenta Praevia Accreta: Diagnosis and Management. London: RCOG Press; 2005.
40.ACOG. Guideline for Perinatal Care, 6th edition. Washington, DC: ACOG; 2007.
41.WHO. Managing Complications in Pregnancy and Childbirth. A Guide for Midwives and Doctors. Geneva: WHO; 2003.