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16 - Dementia treatment

Published online by Cambridge University Press:  31 July 2009

By
Bradley F. Boeve  and
Adam L. Boxer
Edited by
Bruce L. Miller  and
Bradley F. Boeve
Bruce L. Miller
Affiliation:
University of California, San Francisco
Bradley F. Boeve
Affiliation:
Mayo Foundation, Minnesota
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Summary

Introduction

There is reason for optimism about future treatment of the most common causes of dementia. Advances in understanding the molecular pathologies that underlie the most common causes of neurodegenerative dementia are rapidly being translated into new treatments. At the same time, basic investigations into the neurophysiology of synaptic transmission, neuronal growth, development and survival have identified new receptors, genes and intracellular second messenger cascades that may serve as targets for new treatments for dementia. Whereas most currently approved medications that are used to treat dementia are effective only in ameliorating the symptoms of disease, in the near future, medications that modify the course of the disease by protecting the brain from dementia-related pathology may be available. New diagnostic tests will also help to identify accurately who is likely to benefit from such treatment and monitor their treatment response. This chapter will review the currently available treatments for the most common forms of dementia, focusing on clinical syndromes that are readily identifiable by practicing clinicians, as well as new treatments that are currently under investigation or new avenues for treatment suggested by recent advances in understanding the molecular pathologies of these disorders.

Type
Chapter
Information
The Behavioral Neurology of Dementia , pp. 213 - 253
Publisher: Cambridge University Press
Print publication year: 2009

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