Book contents
- Frontmatter
- Contents
- Contributors
- Part I General Principles of Cell Death
- 1 Human Caspases – Apoptosis and Inflammation Signaling Proteases
- 2 Inhibitor of Apoptosis Proteins
- 3 Death Domain–Containing Receptors – Decisions between Suicide and Fire
- 4 Mitochondria and Cell Death
- 5 The Control of Mitochondrial Apoptosis by the BCL-2 Family
- 6 Endoplasmic Reticulum Stress Response in Cell Death and Cell Survival
- 7 Autophagy – The Liaison between the Lysosomal System and Cell Death
- 8 Cell Death in Response to Genotoxic Stress and DNA Damage
- 9 Ceramide and Lipid Mediators in Apoptosis
- 10 Cytotoxic Granules House Potent Proapoptotic Toxins Critical for Antiviral Responses and Immune Homeostasis
- Part II Cell Death in Tissues and Organs
- Part III Cell Death in Nonmammalian Organisms
- Plate section
- References
5 - The Control of Mitochondrial Apoptosis by the BCL-2 Family
from Part I - General Principles of Cell Death
Published online by Cambridge University Press: 07 September 2011
Book contents
- Frontmatter
- Contents
- Contributors
- Part I General Principles of Cell Death
- 1 Human Caspases – Apoptosis and Inflammation Signaling Proteases
- 2 Inhibitor of Apoptosis Proteins
- 3 Death Domain–Containing Receptors – Decisions between Suicide and Fire
- 4 Mitochondria and Cell Death
- 5 The Control of Mitochondrial Apoptosis by the BCL-2 Family
- 6 Endoplasmic Reticulum Stress Response in Cell Death and Cell Survival
- 7 Autophagy – The Liaison between the Lysosomal System and Cell Death
- 8 Cell Death in Response to Genotoxic Stress and DNA Damage
- 9 Ceramide and Lipid Mediators in Apoptosis
- 10 Cytotoxic Granules House Potent Proapoptotic Toxins Critical for Antiviral Responses and Immune Homeostasis
- Part II Cell Death in Tissues and Organs
- Part III Cell Death in Nonmammalian Organisms
- Plate section
- References
Summary
Introduction
A fundamental step in the commitment to apoptosis via the intrinsic pathway is mitochondrial outer membrane permeabilization (MOMP). This step allows the release of proapoptotic proteins from the mitochondrial intermembrane space into the cytoplasm. Once in the cytoplasm, they induce caspase activation, oligonucleosomal DNA cleavage, and other hallmarks of apoptosis. The details of these important events that occur downstream of MOMP are described in Chapter 4. Here we restrict our attention to the molecular mechanisms by which the cell controls this critical event, molecular mechanisms that primarily involve interactions among the family of proteins known as the BCL-2 family.
- Type
- Chapter
- Information
- ApoptosisPhysiology and Pathology, pp. 44 - 50Publisher: Cambridge University PressPrint publication year: 2011
References
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