Apoptosis in the Physiology and Diseases of the Respiratory Tract

Christian Taube; Martin Schuler

doi:10.1017/CBO9780511976094.020

20 - Apoptosis in the Physiology and Diseases of the Respiratory Tract

from Part II - Cell Death in Tissues and Organs

Published online by Cambridge University Press: 07 September 2011

Christian Taube and

Edited by

Douglas R. Green: Affiliation:
St. Jude Children's Research Hospital, Memphis, Tennessee
Christian Taube: Affiliation:
Johannes Gutenberg University Hospital
Martin Schuler: Affiliation:
West German Cancer Center
John C. Reed: Affiliation:
Sanford-Burnham Medical Research Institute, La Jolla, California

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Summary

The lung provides a huge contact interface between the organism and its environment. Its mucosal surfaces must permit gas exchange between the blood and air, but also act as a barrier against a plethora of microorganisms. In addition, inhaled toxins and particles may enter the organism via the lung. Accordingly, inflammatory airway and lung diseases are among the most prevalent human morbidities. Lung cancer, which in most cases can be attributed to tobacco smoking, is the leading cause of cancer-related mortality in the developed world. In this chapter, we summarize the role of apoptotic cell death in lung development and in clinical disease states.

Type: Chapter
Information: Apoptosis
Physiology and Pathology
, pp. 221 - 230

DOI: https://doi.org/10.1017/CBO9780511976094.020 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2011

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20 - Apoptosis in the Physiology and Diseases of the Respiratory Tract

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