This chapter looks at arguably the most unique and important feature of our species: culture. I begin by making the case that natural selection operates not only genes but on the elements of culture - what Richard Dawkins called memes – and that through cumulative cultural evolution, our culture evolves to be smarter than we are. I then run through a series of hypotheses about what natural selection “designs” cultural entities to do. These include the idea that culture is designed to promote the individual’s fitness and the idea that culture is designed to promote the good of the group. In the end, I conclude that cultural entities are designed ultimately to promote their own good, whether or not they’re good for us or our groups (although often they are). This “neo-memetic” approach to culture does not, I argue, supplant other theories of cultural evolution, but instead provides a unifying framework that embraces these theories while also going beyond them. Finally, I look at the coevolution of culture and biology, and consider how modern living conditions might inadvertently promote the survival of the weakest.