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  • Print publication year: 2014
  • Online publication date: September 2014

Chapter 20 - The high-risk or critically ill patient in the operating room


1. BittermanH, ReissmanP, BittermanN, et al. Oxygen therapy in hemorrhagic shock. Circ Shock 1991; 33: 183–91.
2. BrundageSI, McGhanR, JurkovichGJ, et al. Timing of femur fracture fixation: effect on outcome in patients with thoracic and head injuries. J Trauma 2002; 52: 299–307.
3. ParrMJ, AlabdiT. Damage control surgery and intensive care. Injury 2004; 35: 713–22.
4. BaloghZ, McKinleyBA, CocanourCS, et al. Supranormal trauma resuscitation causes more cases of abdominal compartment syndrome. Arch Surg 2003; 138: 637–42.
5. WattsDD, TraskA, SoekenK, et al. Hypothermic coagulopathy in trauma: effect of varying levels of hypothermia on enzyme speed, platelet function, and fibrinolytic activity. J Trauma 1998; 44: 846–54.
6. RajagopalanS, MaschaE, NaJ, et al. The effects of mild perioperative hypothermia on blood loss and transfusion requirement. Anesthesiology 2008; 108: 71–7.
7. FrankSM, FleisherLA, BreslowMJ, et al. Perioperative maintenance of normothermia reduces the incidence of morbid cardiac events: a randomised clinical trial. JAMA 1997: 227: 1127–43.
8. KaralapillaiD, StoryD, HartGK, et al. Postoperative hypothermia and patient outcomes after major elective non-cardiac surgery. Anaesthesia 2013; 68: 605–11.
9. BertiM, CasatiA, TorriG, et al. Active warming, not passive heat retention, maintains normothermia during combined epidural–general anesthesia for hip and knee arthroplasty. J Clin Anesth 1997; 9: 482–6.
10. AubierM, VinesN, SyllieG, et al. Respiratory muscle contribution to lactic acidosis in low cardiac output. Am Rev Resp Dis 1982: 126: 648–52.
11. MorrisC, PerrisA, KleinJ, et al. Anaesthesia in hemodynamically compromised emergency patients: does ketamine represent the best choice of induction agent?Anaesthesia 2009; 64: 532–9.
12. WillmanEV, AndolfattoG. A prospective evaluation of “ketofol” (ketamine/propofol combination) for procedural sedation and analgesia in the emergency department. Ann Emerg Med 2007; 49: 23–30.
13. BogetzMS, KatzJA. Recall of surgery for major trauma. Anesthesiology 1984; 61: 6–9.
14. LongneckerDE, SturgillBC. Influence of anesthetic agent on survival following hemorrhage. Anesthesiology 1976; 45: 516–21.
15. EnglehartMS, AllisonCE, TieuBH, et al. Ketamine-based total intravenous anesthesia versus isoflurane anesthesia in a swine model of hemorrhagic shock. J Trauma 2008; 65: 901–8.
16. IdvallJ. Influence of ketamine anesthesia on cardiac output and tissue perfusion in rats subjected to hemorrhage. Anesthesiology 1981; 55: 297–304.
17. JohnsonKB, EganTD, KernSE, et al. The influence of hemorrhagic shock on propofol: a pharmacokinetic and pharmacodynamic analysis. Anesthesiology 2003; 99: 409–20.
18. JohnsonKB, EganTD, LaymanJ, et al. The influence of hemorrhagic shock on etomidate: a pharmacokinetic and pharmacodynamic analysis. Anesth Analg 2003; 96: 1360–8.
19. JohnsonKB, KernSE, HamberEA, et al. Influence of hemorrhagic shock on remifentanil: a pharmacokinetic and pharmacodynamic analysis. Anesthesiology 2001; 94: 322–32.
20. Yli-HankalaA, KirvelaM, RandellT, et al. Ketamine anaesthesia in a patient with septic shock. Acta Anaesthesiol Scand 1992; 36: 483–5.
21. Van der LindenP, GilbartE, EngelmanE, et al. Comparison of halothane, isoflurane, alfentanil and ketamine in experimental septic shock. Anesth Analg 1990; 70: 608–17.
22. KawasakiC, KawasakiT, OgataM, et al. Ketamine isomers suppress superantigen-induced proinflammatory cytokine production in human whole blood. Can J Anaesth 2001; 48: 819–23.
23. BeilinB, RusabrovY, ShapiraY, et al. Low-dose ketamine affects immune responses in humans during the early postoperative period. Br J Anaesth 2007; 99: 522–7.
24. TaniguchiT, YamamotoK, OhmotoN, et al. Effects of propofol on hemodynamic and inflammatory responses to endotoxemia in rats. Crit Care Med 2000; 28: 1101–6.
25. YuHP, LuiPW, HwangTL, et al. Propofol improves endothelial dysfunction and attenuates vascular superoxide production in septic rats. Crit Care Med 2006; 34: 453–60.
26. KidaniY, TaniguchiT, KanakuraH, et al. Sevoflurane pretreatment inhibits endotoxin-induced shock in rats. Anesth Analg 2005; 101: 1152–6.
27. JabreP, CombesX, LapostolleF, et al. Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial. Lancet 2009; 374: 293–300.
28. BairdCR, HayAW, McKeownDW, et al. Rapid sequence induction in the emergency department: induction drug and outcome of patients admitted to the intensive care unit. Emerg Med J 2009; 26: 576–9.
29. RayDC, HayAW, McKeownDW. Induction drug and outcome of patients admitted to the intensive care unit after emergency laparotomy. Eur J Anaesthesiol 2010; 27: 481–5.
30. GelissenHP, EpemaAH, HenningRH, et al. Inotropic effects of propofol, thiopental, midazolam, etomidate, and ketamine on isolated human atrial muscle. Anesthesiology 1996; 84: 397–403.
31. ParisA, PhilippM, TonnerPH, et al. Activation of alpha 2B-adrenoceptors mediates the cardiovascular effects of etomidate. Anesthesiology 2003: 99; 889–95.
32. BuddeAO, MetsB. Pro: etomidate is the ideal induction agent for a cardiac anesthetic. J Cardiothorac Vasc Anesth 2013; 1: 180–3.
33. MackayCA, TerrisJ, CoatsTJ. Prehospital rapid sequence induction by emergency physicians: is it safe?Emerg Med J 2001; 18: 20–4.
34. VinclairM, BrouxC, FaureP. Duration of adrenal inhibition following a single dose of etomidate in critically ill patients. Intensive Care Med 2008; 34: 714–19.
35. den BrinkerM, Hokken-KoelegaAC, HazelzetJA, et al. One single dose of etomidate negatively influences adrenocortical performance for at least 24 h in children with meningococcal sepsis. Intensive Care Med 2008; 34: 163–8.
36. MorrisC, McAllisterC. Etomidate for emergency anaesthesia; mad, bad and dangerous to know?Anaesthesia 2005; 60: 737–40.
37. AnnaneD. ICU physicians should abandon the use of etomidate!Intensive Care Med 2005; 31: 325–6.
38. StuttmannR, AllolioB, BeckerA, et al. Etomidate versus etomidate and hydrocortisone for anaesthesia induction in abdominal surgical interventions. Anaesthetist 1988; 37: 576–82.
39. CuthbertsonBH, SprungCL, AnnaneD, et al. The effects of etomidate on adrenal responsiveness and mortality in patients with septic shock. Intensive Care Med 2009; 35: 1868–76.
40. RayDC, McKeownDW. Effect of induction agent on vasopressor and steroid use, and outcome in patients with septic shock. Crit Care 2007; 11: R56.
41. PayenJF, DupuisC, Trouve-BuissonT, et al. Corticosteroid after etomidate in critically ill patients: a randomized controlled trial. Crit Care Med 2012; 40: 29–35.
42. DmelloD, TaylorS, O’BrienJ, et al. Outcomes of etomidate in severe sepsis and septic shock. Chest 2010; 138: 1327–32.
43. EhrmanR, WiraC, LomaxA, et al. Etomidate use in severe sepsis and septic shock patients does not contribute to mortality. Intern Emerg Med 2011; 6: 253–7.
44. ElliotM, BrownG, KuoIF. Does etomidate increase vasopressor requirements in patients needing mechanical ventilation?Can J Hosp Pharm 2012; 65: 272–6.
45. ChanCM, MitchellAL, ShorrAF. Etomidate is associated with mortality and adrenal insufficiency in sepsis: a meta-analysis. Crit Care Med 2012; 40: 2945–53.
46. McPheeLC, BadawiO, FraserGL, et al. Single-dose etomidate is not associated with increased mortality in ICU patients with sepsis: analysis of a large electronic ICU database. Crit Care Med 2013; 41: 774–83.
47. Jevtovic-TodorovicV, WozniakDF, BenshoffND, et al. A comparative evaluation of the neurotoxic properties of ketamine and nitrous oxide. Brain Res. 2001; 895: 264–7.
48. BadnerNH, BeattieWS, FreemanD, et al. Nitrous oxide-induced increased homocysteine concentrations are associated with increased postoperative myocardial ischemia in patients undergoing carotid endarterectomy. Anesth Analg 2000; 91: 1073–9.
49. MylesPS, ChanMT, LeslieK, et al. Effect of nitrous oxide on plasma homocysteine and folate in patients undergoing major surgery. Br J Anaesth 2008; 100: 780–6.
50. MylesPS, ChanMT, KayeDM, et al. Effect of nitrous oxide anesthesia on plasma homocysteine and endothelial function. Anesthesiology 2008; 109: 657–63.
51. LehmbergJ, WaldnerM, BaethmannA, et al. Inflammatory response to nitrous oxide in the central nervous system. Brain Res 2008; 1246: 88–95.
52. MylesPS, LeslieK, ChanMT, et al. Avoidance of nitrous oxide for patients undergoing major surgery: a randomized controlled trial. Anesthesiology 2007; 107: 221–31.
53. LeslieK, MylesPS, ChanMT, et al. Nitrous oxide and long-term morbidity and mortality in the ENIGMA trial. Anesth Analg 2011; 112: 387–93.
54. Del GuercioLRN, CohnJD. Monitoring operative risk in the elderly. JAMA 1980; 297: 845–50.
55. TavernierB, MakhotineO, LebuffeG, et al. Systolic pressure variation as a guide to fluid therapy in patients with sepsis-induced hypotension. Anesthesiology 1998; 89: 1313–21.
56. DerichardA, RobinE, TavernierB, et al. Automated pulse pressure and stroke volume variations from radial artery: evaluation during major abdominal surgery. Br J Anaesth 2009; 103: 678–84.
57. LahnerD, KabonB, MarschalekC, et al. Evaluation of stroke volume variation obtained by arterial pulse contour analysis to predict fluid responsiveness intraoperatively. Br J Anaesth 2009; 103: 346–51.
58. HarveyS, HarrisonDA, SingerM, et al. Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): a randomised controlled trial. Lancet 2005; 366: 472–7.
59. American Society of Anesthesiologists Task Force on Pulmonary Artery Catheterization. Practice guidelines for pulmonary artery catheterization: an updated report by the American Society of Anesthesiologists Task Force on Pulmonary Artery Catheterization. Anesthesiology 2003; 99: 988–1014.
60. SchoberP, LoerSA, SchwarteLA. Perioperative hemodynamic monitoring with transesophageal Doppler technology. Anesth Analg 2009; 109: 340–53.
61. BelloniL, PisanoA, NataleA, et al. Assessment of fluid-responsiveness parameters for off-pump coronary artery bypass surgery: a comparison among LiDCO, transesophageal echochardiography, and pulmonary artery catheter. J Cardiothorac Vasc Anesth 2008; 22: 243–8.
62. SchulmeyerMC, SantelicesE, VegaR, et al. Impact of intraoperative transesophageal echocardiography during noncardiac surgery. J Cardiothorac Vasc Anesth 2006; 20: 768–71.
63. SkinnerH, Morgan-HughesN, SwanevelderJ, et al. Accreditation in transoesophageal echocardiography in the UK: the initial experience. Br J Anaesth 2012; 109: 487–90.
64. KleinAA, SnellA, NashefSA, et al. The impact of intra-operative transoesophageal echocardiography on cardiac surgical practice. Anaesthesia 2009; 64: 947–52.
65. MimozO, RaussA, RekikN, et al. Pulmonary artery catheterization in critically ill patients: a prospective analysis of outcome changes associated with catheter-prompted changes in therapy. Crit Care Med 1994; 22: 573–9.
66. American Society of Anesthesiologists and Society of Cardiovascular Anesthesiologists Task Force on Transesophageal Echocardiography. Practice guidelines for perioperative transesophageal echocardiography. An updated report by the American Society of Anesthesiologists and the Society of Cardiovascular Anesthesiologists Task Force on Transesophageal Echocardiography. Anesthesiology 2010; 112: 1084–96.
67. WiseJ. Boldt: the great pretender. BMJ 2013; 346: f1738.
68. BayerO, ReinhartK, KohlM, et al. Effects of fluid resuscitation with synthetic colloids or crystalloids alone on shock reversal, fluid balance, and patient outcomes in patients with severe sepsis: a prospective sequential analysis. Crit Care Med 2012; 40: 2543–51.
69. MyburghJA, FinferS, BellomoR, et al. Hydroxyethyl starch or saline for fluid resuscitation in intensive care. N Engl J Med 2012; 367: 1901–11.
70. PernerA, HaaseN, GuttormsenAB, et al. Hydroxyethyl starch 130/0.42 versus Ringer’s acetate in severe sepsis. N Engl J Med 2012; 367: 124–34.
71. ZarychanskiR, Abou-SettaAM, TurgeonAF, et al. Association of hydroxyethyl starch administration with mortality and acute kidney injury in critically ill patients requiring volume resuscitation: a systematic review and meta-analysis. JAMA 2013; 309: 678–88.
72. HaaseN, PernerA, HenningsLI, et al. Hydroxyethyl starch 130/0.38–0.45 versus crystalloid or albumin in patients with sepsis: systematic review with meta-analysis and trial sequential analysis. BMJ 2013; 346: f839.
73. PerelP, RobertsI, KerK. Colloids versus crystalloids for fluid resuscitation in critically ill patients. Cochrane Database Syst Rev. 2013; 2: CD000567.
74. Van der LindenP, JamesM, MythemM, et al. Safety of modern starches used during surgery. Anesth Analg 2013; 113: 35–48.
75. NolanJP, MythenMG. Hydroxyethyl starch: here today, gone tomorrow. Br J Anaesth 2013; 111: 321–4.
76. WilkesNJ, WoolfR, MutchM, et al. The effects of balanced versus saline-based hetastarch and crystalloid solutions on acid-base and electrolyte status and gastric mucosal perfusion in elderly surgical patients. Anesth Analg 2001; 93: 811–16.
77. WatersJH, GottliebA, SchoenwaldP, et al. Normal saline versus lactated Ringer’s solution for intraoperative fluid management in patients undergoing abdominal aortic aneurysm repair: an outcome study. Anesth Analg 2001; 93: 817–22.
78. McCluskeySA, KarkoutiK, WijeysunderaD, et al. Hyperchloremia after noncardiac surgery is independently associated with increased morbidity and mortality: a propensity-matched cohort study. Anesth Analg 2013; 117: 412–21.
79. YunosNM, BellomoR, HegartyC, et al. Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults. JAMA 2012; 308: 1566–72.
80. ButterworthJF IV, MythenMG. Should “normal” saline be our usual choice in normal surgical patients?Anesth Analg 2013; 117: 290–1.
81. MythenMG, WebbAR. Perioperative plasma volume expansion reduces the incidence of gut mucosal hypoperfusion during cardiac surgery. Arch Surg 1995: 130: 423–9.
82. GanTJ, SoppittA, MaroofM, et al. Goal-directed intraoperative fluid administration reduces length of hospital stay after major surgery. Anesthesiology 2002; 97: 820–6.
83. RiversE, NguyenB, HavstadS, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001; 345: 1368–77.
84. PearseR, DawsonD, FawcettJ, et al. Changes in central venous saturation after major surgery, and association with outcome. Crit Care 2005; 9: R694–9.
85. BickellWH, WallMJ Jr, PepePE, et al. Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries. N Engl J Med 1994; 331: 1105–9.