The nature of the cosmos and its maintenance are central issues in Mesoamerican philosophy. The correlative metaphysical systems of Mesoamerica, with their focus on interdependence, transformation, and continual creation, rely on particular views about the nature of the world and its operation that are covered in this chapter. The chapter covers the development of key concepts connected to creation and change, as well as the particular ways these are developed in creation stories across Mesoamerica. Creation stories serve an important purpose in Mesoamerican thought. They should not be thought of as only myth grounding the overall tradition and system, but also as discussions of the nature of being, change, and continual creation.