This chapter focuses on specific issues related to attention-deficit hyperactivity disorder (ADHD) in women. It includes the unique presentation and the psychological effects related to late diagnosis, coexisting conditions commonly seen in women with ADHD, and the challenge of providing an appropriate treatment plan for women with ADHD. In general, females with ADHD report emotional instability characterized by fluctuating anxiety, depression, and sudden mood swings leading to difficulty in selfregulation. Comorbid disorders in females with ADHD are often different from those seen in males with ADHD. Higher rates of anxiety, mood, and eating disorders and hormonal fluctuations often complicate the picture of ADHD in women. The coexistence of ADHD and depression, which becomes such an integral part of the disorder in some women, and the role of hormonal fluctuations over the life span need to be explored in particular.