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Chapter 14 - Oxidative Stress Testing: Direct Tests

Published online by Cambridge University Press:  05 April 2021

Ashok Agarwal
The Cleveland Clinic Foundation, Cleveland, OH
Ralf Henkel
University of the Western Cape, South Africa
Ahmad Majzoub
Hamad Medical Corporation, Doha
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Seminal oxidative stress (OS) is a condition where the levels of oxidants overwhelm those of the antioxidants (reductants) present in the semen [1]. The most important oxidants are reactive oxygen species (ROS), a group of oxygen-based molecules including radicals (e.g. superoxide anion – O2-.; hydroxyl radical – OH.; peroxyl radicals – ROO.; alkoxyl radicals – RO.; organic hydroperoxides – ROOH) and non-radical species (hydrogen peroxide – H2O2). Free radicals are molecules with one or more unpaired electrons in the outer orbit, which are highly reactive towards any kind of cellular components (lipids, proteins and DNA).

Publisher: Cambridge University Press
Print publication year: 2021

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