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36A - There Is Value in Examining Sperm DNA Fragmentation

For

from Section VI - Male-factor Infertility

Published online by Cambridge University Press:  25 November 2021

By
Lesley Haddock  and
Sheena EM Lewis
Edited by
Roy Homburg ,
Adam H. Balen  and
Robert F. Casper
Roy Homburg
Affiliation:
Homerton University Hospital, London
Adam H. Balen
Affiliation:
Leeds Centre for Reproductive Medicine
Robert F. Casper
Affiliation:
Mount Sinai Hospital, Toronto
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Summary

For over a decade it has been abundantly clear that a semen analysis is unfit for purpose Is it ethical to continue using outdated semen analysis tools that result in a useless diagnosis of idiopathic infertility in 30% of men? Data from the four sperm DNA tests is not interchangeable Only the Comet is a quantitative test measuring the damage in individual sperm There is a strong correlation between sperm DNA quality and both IVF and ICSI live births using the Comet assay. High DNA damage (high Comet score) is just as important as female age Sperm DNA damage is significantly correlated with an increased risk of sporadic and recurrent miscarriages following natural conceptions and following both IVF and ICSI Double strand breaks may be more predictive for treatment failure than single strand breaks

Type
Chapter
Information
50 Big Debates in Reproductive Medicine , pp. 183 - 185
Publisher: Cambridge University Press
Print publication year: 2021

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References

Simon, L, Zini, A, Dyachenko, A, et al. A systematic review and meta-analysis to determine the effect of sperm DNA damage on in vitro fertilization and intracytoplasmic sperm injection outcome. Asian J Androl. 2017;19(1):80–90.Google ScholarPubMed
Smith, ADAC, Tilling, K, Nelson, SM, Lawlor, DA. Live-birth rate associated with repeat in vitro fertilization treatment cycles. JAMA. 2015;314:2654–62.CrossRefGoogle ScholarPubMed
Nicopoullos, J, Vicens-Morton, A, Lewis, SEM. Novel use of COMET parameters of sperm DNA damage may increase its utility to diagnose male infertility and predict live births following both IVF and ICSI. Hum Reprod. 2019;34(10):1915–23.CrossRefGoogle ScholarPubMed
Smits, RM, Mackenzie-Proctor, R, Yazdani, A, et al. Antioxidants for male subfertility. Cochrane Database Syst Rev. March 2019. https://doi.org/10.1002/14651858.CD007411.pub4.CrossRefGoogle Scholar
Robinson, L, Gallos, ID, Conner, SJ, et al. The effect of sperm DNA fragmentation on miscarriage rates: a systematic review and meta-analysis. Hum Rep. 2012;27:2908–17.CrossRefGoogle Scholar

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