Clomazone is used in the Central Great Plains for weed control during fallow in a winter wheat-fallow rotation. Improved precipitation storage during non-crop periods has stimulated new crop rotations such as winter wheat-corn or proso millet-fallow. The objective of this study was to determine if clomazone applied in the fall after winter wheat harvest would injure succeeding spring-planted crops. Greenhouse studies indicated crop tolerance to clomazone was in the order of safflower > corn > proso millet > barley > winter wheat. Clomazone did not affect grain yields of safflower, corn, or proso millet grown at two field sites with different soil textures (silt loam and sandy loam), nor germination of seed from treated plants of these crops. A no-till production system with clomazone increased grain yields for all crops compared to the conventional system where tillage replaced clomazone for fallow weed control.