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1 results

  • SPARC and Vav3 Expression in Meningioma: Factors Related to Prognosis
  • Jie Jiang, Yuejia Song, Nan Liu, Chengjun Lin, Shiguang Zhao, Yu Sun, Zhen Zhang, Xiang Fang, Jiping Qi
  • Journal: Canadian Journal of Neurological Sciences / Volume 40 / Issue 6 / November 2013
  • Published online by Cambridge University Press: 23 September 2014, pp. 814-818
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    Background:

    Meningiomas account for approximately 24-30% of primary intracranial neoplasms. Histopathologic grade and degree of resection are two major prognostic factors. The aim of this study was to determine the factors associated with the prognosis of meningioma.

    Methods:

    We used immunohistochemistry to analyze the expression levels of Vav3, SPARC, p-Akt, cyclin D1, and Ki-67 in 287 meningiomas of all grades.

    Results:

    The expression of Vav3, SPARC, p-Akt, cyclin D1, and Ki- 67 significantly increased with meningioma grade (p<0.01), and was higher in brain-invasive meningiomas compared to non-invasive meningiomas (WHO grade I) (p<0.05). Furthermore, the expression of Vav3, p-Akt, and Ki-67 was higher in recurrent meningiomas compared to non-recurrent meningiomas (WHO grade I) (p<0.05).

    Conclusion:

    The expression of Vav3, SPARC, p-Akt, cyclin D1, and Ki-67 in meningiomas appears to correlate with meningioma invasiveness, aggressiveness, and recurrence.