Immune dysfunction has been proposed as a mechanism for the pathophysiology
of autistic-spectrum disorders. The selectin family of adhesion molecules
plays a prominent role in immune/inflammatory responses. We determined the
serum levels of three types of soluble-form selectin (sP, sL and sE) in 15
men with high-functioning autism and 22 age-matched healthy controls by
enzyme-linked immunosorbent assay. Levels of sP-selectin and sL-selectin
were significantly lower in patients than in controls. Furthermore,
sP-selectin levels were negatively correlated with impaired social
development during early childhood.