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This study identified possible risk factors for newly diagnosed mood disorders, including depressive and bipolar disorders, in prostate cancer patients.
From 2000 to 2006, two cohorts were evaluated on the occurrence of mood disorder diagnosis and treatment. For the first cohort, data of patients diagnosed with prostate cancer was obtained from the Taiwan National Health Insurance (NHI) Research Database. As the second cohort, a cancer-free comparison group was matched for age, comorbidities, geographic region, and socioeconomic status.
Final analyses involved 12,872 men with prostate cancer and 12,872 matched patients. Increased incidence of both depressive (IRR 1.52, 95% CI 1.30–1.79, P <0.001) and bipolar disorder (IRR 1.84, 95% CI 1.25–2.74, P = 0.001) was observed among patients diagnosed with prostate cancer. Multivariate matched regression models show that cerebrovascular disease (CVD) and radiotherapy treatment could be independent risk factors for developing subsequent depressive and bipolar disorders.
We observed that the risk of developing newly diagnosed depressive and bipolar disorders is higher among Taiwanese prostate cancer patients. Clinicians should be aware of the possibility of increased depressive and bipolar disorders among prostate cancer patients in Taiwan. A prospective study is necessary to confirm these findings.
This study develops a novel image-guided robotic system that can be used to position biopsy needles or drill fixation holes. After the patient has received a CT-scan, the registration of the image, localizer (patient), and robot frames will be done by finding the optimum transformation matrix among the image and localizer coordinates of the fiducial markers and the DRFs mounted on the robot. Then, surgical paths planned on the computer displayed images can be transformed to the robot frame, and the robot is thus capable to move surgical tools to the preplanned location. The positioning error is about 2 mm and the orientation error is about 0.23°.
TiO2 thin films prepared by metalorganic decomposition (MOD-TiO2) and sol-gel processes (SG-TiO2) were investigated in terms of the anatase-to-rutile phase transformation and microstructural evolution. It was found that the chemical reactivity of the ligand groups initially coordinated on the titanium precursor plays a decisive role in the structure development of as-deposited SG- and MOD-TiO2 films. MOD-TiO2 films consist of small aggregated particles and therefore, tend to coalesce together to form an inhomogeneous microstructure during the anatase-to-rutile phase transformation. On the other hand, SG-TiO2 films consist of uniform large particles that tend to grow homogeneously. MOD-TiO2 films showed a higher crystallization temperature than the SG-TiO2 films but the temperature of the anatase-to-rutile phase transformation is much lower in MOD- (approximately 775 °C) as compared to SG-TiO2 films (approximately 930 °C). The activation energy (Q) was estimated as 524 and 882 kJ/mol for the MOD- and SG-TiO2 films, respectively. The lower transformation temperature and activation energy in MOD-TiO2 films were due to smaller grain size and more potential nucleation sites existing in the un-transformed MOD-TiO2 film structure, which can accelerate the rate of anatase-to-rutile transformation.
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