In the present study, the phase evolution and microstructure of CrMoNbTiW, a new equi-atomic refractory high-entropy alloy, are studied. The alloy was synthesized through mechanical alloying (MA) followed by consolidation using spark plasma sintering. After MA, a major BCC solid solution along with residual Cr and Nb were observed. However, secondary phases such as Laves and carbides were also observed in addition to the major BCC solid solution after sintering. Unsolicited contamination from the milling media is found to be one of the reasons for the formation of secondary phases. The high hardness of 8.9 GPa after sintering was attributed to the presence of secondary phases along with the nanocrystalline nature of the alloy. To understand the phase evolution, calculation of phase diagram was carried out using CALPHAD. Further, binary phase diagram inspection and simple empirical parameters were also used to assess their effectiveness in predicting phases.