We describe an outbreak of echovirus 18 infection involving 10 patients in our neonatal intensive care unit (an attack rate of 33%). The mean age at the onset of illness was 26.8 days. Eighty percent were preterm infants. All were discharged home without sequelae. There were no differences in gestation age, birth weight, delivery mode, use of antibiotics, and parenteral nutrition between the enterovirus (EV) group and non-EV group, but the rate of breastfeeding was significantly higher in the EV group. Separation care and reinforcement of hand-washing seemed to be effective in preventing further spread of the virus. Visiting policy, hygiene practice, and handling of expressed breastmilk should be reinforced.

One of the most common harmful mites in edible fungi is Histiostoma feroniarum Dufour (Acaridida: Histiostomatidae), a fungivorous astigmatid mite that feeds on hyphae and fruiting bodies, thereby transmitting pathogens. This study examined the effects of seven constant temperatures and 10 types of mushrooms on the growth and development of H. feroniarum, as well as its host preference. Developmental time for the total immature stages was significantly affected by the type of mushroom species, ranging from 4.3 ± 0.4 days (reared on Pleurotus eryngii var. tuoliensis Mou at 28°C) to 17.1 ± 2.3 days (reared on Auricularia polytricha Sacc. at 19°C). The temperature was a major factor in the formation of facultative heteromorphic deutonymphs (hypopi). The mite entered the hypopus stage when the temperature dropped to 16°C or rose above 31°C. The growth and development of this mite were significantly influenced by the type of species and variety of mushrooms. Moreover, the fungivorous astigmatid mite preferred to feed on the ‘Wuxiang No. 1’ strain of Lentinula edodes (Berk.) Pegler and the ‘Gaowenxiu’ strain of P. pulmonarius (Fr.) Quél., with a shorter development period compared with that of feeding on other strains. These results therefore quantify the effect of host type and temperature on fungivorous astigmatid mite growth and development rates, and provide a reference for applying mushroom cultivar resistance to biological pest control.

The clinical characteristics of patients with COVID-19 were analysed to determine the factors influencing the prognosis and virus shedding time to facilitate early detection of disease progression. Logistic regression analysis was used to explore the relationships among prognosis, clinical characteristics and laboratory indexes. The predictive value of this model was assessed with receiver operating characteristic curve analysis, calibration and internal validation. The viral shedding duration was calculated using the Kaplan–Meier method, and the prognostic factors were analysed by univariate log-rank analysis and the Cox proportional hazards model. A retrospective study was carried out with patients with COVID-19 in Tianjin, China. A total of 185 patients were included, 27 (14.59%) of whom were severely ill at the time of discharge and three (1.6%) of whom died. Our findings demonstrate that patients with an advanced age, diabetes, a low PaO2/FiO2 value and delayed treatment should be carefully monitored for disease progression to reduce the incidence of severe disease. Hypoproteinaemia and the fever duration warrant special attention. Timely interventions in symptomatic patients and a time from symptom onset to treatment <4 days can shorten the duration of viral shedding.

The Weibel instability and the induced magnetic field are of great importance for both astrophysics and inertial confinement fusion. Because of the stochasticity of this magnetic field, its main wavelength and mean strength, which are key characteristics of the Weibel instability, are still unobtainable experimentally. In this paper, a theoretical model based on the autocorrelation tensor shows that in proton radiography of the Weibel-instability-induced magnetic field, the proton flux density on the detection plane can be related to the energy spectrum of the magnetic field. It allows us to extract the main wavelength and mean strength of the two-dimensionally isotropic and stochastic magnetic field directly from proton radiography for the first time. Numerical calculations are conducted to verify our theory and show good consistency between pre-set values and the results extracted from proton radiography.

The Linkuo terrace, situated to the west of the Taipei Basin in NW Taiwan, has thick red soils that have been little studied. This paper aims to interpret the development of these soils through chemical and micromorphological investigations, and relate the soils to their palaeo-environments. The soil samples were air dried, crushed and passed through a 2 mm sieve, and then subjected to conventional soil chemical and physical analyses, together with clay mineralogical and morphological characterization. Pedons I and II were clay with low base saturation (BS), cation-exchange capacity (CEC), and exchangeable cations. The pH of pedons I and II ranged from 3.80 to 5.26. The low magnetic susceptibility of these soils indicates that no magnetite (Fe3O4) or maghemite (γ-Fe2O3) are present. X-ray diffraction patterns of the magnetic clay fraction showed lepidocrocite, goethite and hematite, the amounts of which may relate to water fluctuation in the soil environments. Illite, kaolinite and quartz are major clay minerals in the red soil clay fractions. The micromorphology of all horizons showed a great accumulation of Fe-oxides. The upper horizon showed darkened isotropic Fe-oxide materials, and lower horizon showed a black to reddish dense plasma with soil matrix. The groundmass of the oxic horizon is generally characterized by a homogeneous distribution of the different coarse and fine constituents. The thick (4 m depth) and homogeneous red soils of the Linkuo terrace were developed from fine sediments after the gradual subsidence of the Taipei Basin. Alarge amount of gravel was flushed from the Xindian River before the Taipei Basin subsided. The Linkuo red soils can be classified as mesic, Typic Kandiudox. From the chemical compositions of clay fractions and the red soil features, these red soils can be considered as lateritic red earths or red earths that do not reach the criteria for laterite.

The parameters of X-ray radiation and runaway electron beams (RAEBs) generated at long-pulse discharges in atmospheric-pressure air were investigated. In the experiments, high-voltage pulses with the rise times of 500 and 50 ns were applied to an interelectrode gap. The gap geometry provided non-uniform distribution of the electric field strength. It was founded that at the voltage pulse rise time of 500 ns and the maximum breakdown voltage Um for 1 cm-length gap, a duration [full width at half maximum (FWHM)] of a RAEB current pulse shrinks to 0.1 ns. A decrease in the breakdown voltage under conditions of a diffuse discharge leads to an increase in the FWHM duration of the electron beam current pulse up to several nanoseconds. It was shown that when the rise time of the voltage pulse is of 500 ns and the diffuse discharge occurs in the gap, the FWHM duration of the X-ray radiation pulse can reach ≈100 ns. It was established that at a pulse-periodic diffuse discharge fed by high-voltage pulses with the rise time of 50 ns, an energy of X-ray quanta and their number increase with increasing breakdown voltage. Wherein the parameter Um/pd is saved.

In high power laser facility for inertial confinement fusion research, final optics assembly (FOA) plays a critical role in the frequency conversion, beam focusing, color separation, beam sampling and debris shielding. The design and performance of FOA in SG-II Upgrade laser facility are mainly introduced here. Due to the limited space and short focal length, a coaxial aspheric wedged focus lens is designed and applied in the FOA configuration. Then the ghost image analysis, the focus characteristic analysis, the B integral control design and the optomechanical design are carried out in the FOA design phase. In order to ensure the FOA performance, two key technologies are developed including measurement and adjustment technique of the wedged focus lens and the stray light management technique based on ground glass. Experimental results show that the design specifications including laser fluence, frequency conversion efficiency and perforation efficiency of the focus spot have been achieved, which meet the requirements of physical experiments well.

The Shen-Guang II Upgrade (SG-II-U) laser facility consists of eight high-power nanosecond laser beams and one short-pulse picosecond petawatt laser. It is designed for the study of inertial confinement fusion (ICF), especially for conducting fast ignition (FI) research in China and other basic science experiments. To perform FI successfully with hohlraum targets containing a golden cone, the long-pulse beam and cylindrical hohlraum as well as the short-pulse beam and cone target alignment must satisfy tight specifications (30 and $20~\unicode[STIX]{x03BC}\text{m}$ rms for each case). To explore new ICF ignition targets with six laser entrance holes (LEHs), a rotation sensor was adapted to meet the requirements of a three-dimensional target and correct beam alignment. In this paper, the strategy for aligning the nanosecond beam based on target alignment sensor (TAS) is introduced and improved to meet requirements of the picosecond lasers and the new six LEHs hohlraum targets in the SG-II-U facility. The expected performance of the alignment system is presented, and the alignment error is also discussed.

The rock art and the associated natural scenery at 38 sites located in the Zuojiang River valley, in the southwest of Guangxi Zhuang Autonomous Region, southern China, were inscribed recently on UNESCO’s World Heritage List. The painted panel at the site of Mt. Huashan is probably the largest known rock art panel in the world, consisting of approximately 1900 identifiable figures and occupying an area of approximately 8000 m2. To determine a precise age on the rock art at Mt. Huashan, 56 secondary carbonate layers above and below the paintings were studied for their mineralogy, oxygen, and carbon isotopic compositions and dated by the 230Th/U method. The 230Th/U dating results demonstrate that ages of the rock paintings can be bracketed between 1856±16 and 1728±41yr BP corresponding to the middle to the end of the Eastern Han dynasty (AD 25 to 220). The results imply that the rock painting practices at Mt. Huashan probably lasted more than a century, and the Zuojiang rock art is younger than that at Baiyunwan and Cangyuan in Yunnan Province by 1 to 10 centuries.

The Myanmar snub-nosed monkey Rhinopithecus strykeri was discovered in 2010 on the western slopes of the Gaoligong Mountains in the Irrawaddy River basin in Myanmar and subsequently in the same river basin in China, in 2011. Based on 2 years of surveying the remote and little disturbed forest of the Gaoligong Mountains National Nature Reserve in China, with outline transect sampling and infrared camera monitoring, a breeding group comprising > 70 individuals was found on the eastern slopes of the Gaoligong Mountains in the Salween River Basin. Given the Critically Endangered status of this primate (a total of < 950 individuals are estimated to remain in the wild), efforts to protect the relatively undisturbed habitat of this newly discovered population and to prevent hunting are essential for the long-term survival of this species.

Nanosecond pulse discharges can provide high reduced electric field for exciting high-energy electrons, and the ultrafast rising time of the applied pulse can effectively suppress the generation of spark streamer and produce homogeneous discharges preionized by runaway electrons in atmospheric-pressure air. In this paper, the electrostatic field in a tube-plate electrodes gap is calculated using a calculation software. Furthermore, a simple physical model of nanosecond pulse discharges is established to investigate the behavior of the runaway electrons during the nanosecond pulse discharges with a rise time of 1.6 ns and a full-width at half-maximum of 3–5 ns in air. The physical model is coded by a numerical software, and then the runaway electrons and electron avalanche are investigated under different conditions. The simulated results show that the applied voltage, voltage polarity, and gas pressure can significantly affect the formation of the avalanche and the behavior of the runaway electrons. The inception time of runaway breakdown decreases when the applied voltage increases. In addition, the threshold voltage of runaway breakdown has a minimum value (10 kPa) with the variation of gas pressure.

PACS: 52.80.-s

The bioavailability of dietary ionised calcium is affected by intestinal basic environment. Calcium-binding peptides can form complexes with calcium to improve its absorption and bioavailability. The aim of this study was focused on isolation and characterisation of a calcium-binding peptide from whey protein hydrolysates. Whey protein was hydrolysed using Flavourzyme and Protamex with substrate to enzyme ratio of 25 : 1 (w/w) at 49 °C for 7 h. The calcium-binding peptide was isolated by DEAE anion-exchange chromatography, Sephadex G-25 gel filtration and reversed phase high-performance liquid chromatography (RP-HPLC). A purified peptide of molecular mass 204 Da with strong calcium binding ability was identified on chromatography/electrospray ionisation (LC/ESI) tandem mass spectrum to be Glu-Gly (EG) after analysis and alignment in database. The calcium binding capacity of EG reached 67·81 μg/mg, and the amount increased by 95% compared with whey protein hydrolysate complex. The UV and infrared spectrometer analysis demonstrated that the principal sites of calcium-binding corresponded to the carboxyl groups and carbonyl groups of glutamic acid. In addition, the amino group and peptide amino are also the related groups in the interaction between EG and calcium ion. Meanwhile, the sequestered calcium percentage experiment has proved that EG-Ca is significantly more stable than CaCl2 in human gastrointestinal tract in vitro. The findings suggest that the purified dipeptide has the potential to be used as ion-binding ingredient in dietary supplements.

In this work, the generation of a super-short avalanche electron beam (SAEB) in SF6 in an inhomogeneous electric field is studied on two generators with pulse rise times of 0.5 and 2 ns, respectively. The SAEB parameters in SF6 are compared with those obtained in other gases (air, nitrogen, argon, and krypton). It is shown that the SAEB amplitude in SF6 at pressures ranging from 0.05 to 0.2 MPa is commensurable with that in krypton and is much lower than that in air and nitrogen. It is also found that in SF6, SF6 mixture with 2.5% of nitrogen, and other gases, a diffuse discharge is ignited not only at negative polarity but also at positive polarity of the electrode with small curvature radius. Furthermore, the velocity of the ionization wave front in SF6 in an inhomogeneous electric field is studied. Experimental results show that the velocity of the ionization wave front in SF6 is lower than that in air and nitrogen as well as such velocity decreases when the pressure increases from 0.05 to 0.3 MPa in all gases.