Latinos, especially those who recently immigrated, face many obstacles in navigating the political and judicial environment in the United States. While prior scholarship suggests that racial minorities are more likely to be stopped by law enforcement for traffic violations and face harsher penalties for major crimes, little research has explored whether a defendant’s characteristics are influential in routine traffic court cases. Using an original database, this paper examines disparate treatment in speeding ticket reductions. The results indicate that Latino defendants are less likely to receive meaningful reductions to their charges. However, attorney representation greatly lessens the likelihood of disparate treatment for Latino drivers. As traffic court proceedings often represent the only interaction most people have with the judicial system, these findings have significant implications for racial equality, the administration of justice, attorney representation, and public opinion of the judiciary.

OBJECTIVES/GOALS: We aim to determine whether non-neuronal, non-synaptic glutamate signaling mechanisms can be targeted to produce highly specific, narrow changes in brain function that would benefit CNS disorders. To do this, we investigated cognitive changes produced through manipulating the activity of the astrocytic glutamate release mechanism system xc-. METHODS/STUDY POPULATION: System xc- (Sxc) activity was eliminated by mutating the gene Slc7a11 through pronuclear injection of zinc-finger nucleases into Sprague Dawley rat embryos to create a line of rats lacking Sxc (MSxc rats). To confirm a lack of Sxc activity, we verified that tissue from MSxc rats had a complete lack of xCT, which is the regulatory subunit of Sxc that is encoded by Slc7a11. We also verified that astrocyte cultures generated from MSxc tissue lacked cystine-evoked glutamate release. Next, we measured development (body weight), CNS regulation of metabolism, and other indicators of generalized, non-specific brain function as well as behaviors that are reliant on executive function, such as cognitive flexibility, impulse control, decision-making, and response inhibition. RESULTS/ANTICIPATED RESULTS: Eliminating Sxc was not lethal and did not impair development or produce widespread changes in brain function as is commonly observed when deleting other glutamate mechanisms. MSxc rats did not differ from wildtype in growth rate, central regulation of metabolism as reflected by absolute or diurnal changes in core body temperature, locomotor activity in a familiar or novel environment, or simple forms of cognition such as novel object recognition, or operant responding (food and cocaine-reinforced). In contrast, behaviors that rely on executive function were impaired. MSxc rats displayed deficits in cocaine reinstatement and attentional set-shifting. We anticipate MSxc rats to also show impairments in decision-making in the rat gambling task and response inhibition in the stop-signal reaction time task. DISCUSSION/SIGNIFICANCE: Eliminating Sxc activity in rats produced deficits in behaviors reliant on executive function without impacting development or simple brain function. These results highlight the potential of targeting Sxc to enhance cognition without generating therapeutically limiting adverse effects resulting from non-specific changes in brain function.

Given the relatively small industry scale of cow-calf operations in New York to other regions of the country, little is known about differences in determinant values for feeder cattle. Using auction prices and quality characteristics over 7 years, differences in market, lot, and quality parameters suggest opportunities for improved marketing performance. A delta profit model is constructed to inform timing of marketing decisions for producers. The results indicate a relatively high potential for producers to increase farm returns by delaying sales of lighter-weight feeder cattle from the fall to spring auction months, given sufficient rates of gain and reasonable overwintering costs.

In 2020 a group of U.S. healthcare leaders formed the National Organization to Prevent Hospital-Acquired Pneumonia (NOHAP) to issue a call to action to address non–ventilator-associated hospital-acquired pneumonia (NVHAP). NVHAP is one of the most common and morbid healthcare-associated infections, but it is not tracked, reported, or actively prevented by most hospitals. This national call to action includes (1) launching a national healthcare conversation about NVHAP prevention; (2) adding NVHAP prevention measures to education for patients, healthcare professionals, and students; (3) challenging healthcare systems and insurers to implement and support NVHAP prevention; and (4) encouraging researchers to develop new strategies for NVHAP surveillance and prevention. The purpose of this document is to outline research needs to support the NVHAP call to action. Primary needs include the development of better models to estimate the economic cost of NVHAP, to elucidate the pathophysiology of NVHAP and identify the most promising pathways for prevention, to develop objective and efficient surveillance methods to track NVHAP, to rigorously test the impact of prevention strategies proposed to prevent NVHAP, and to identify the policy levers that will best engage hospitals in NVHAP surveillance and prevention. A joint task force developed this document including stakeholders from the Veterans’ Health Administration (VHA), the U.S. Centers for Disease Control and Prevention (CDC), The Joint Commission, the American Dental Association, the Patient Safety Movement Foundation, Oral Health Nursing Education and Practice (OHNEP), Teaching Oral-Systemic Health (TOSH), industry partners and academia.

Let $M$ be a regular matroid. The Jacobian group $\text{Jac}(M)$ of $M$ is a finite abelian group whose cardinality is equal to the number of bases of $M$. This group generalizes the definition of the Jacobian group (also known as the critical group or sandpile group) $\operatorname{Jac}(G)$ of a graph $G$ (in which case bases of the corresponding regular matroid are spanning trees of $G$). There are many explicit combinatorial bijections in the literature between the Jacobian group of a graph $\text{Jac}(G)$ and spanning trees. However, most of the known bijections use vertices of $G$ in some essential way and are inherently ‘nonmatroidal’. In this paper, we construct a family of explicit and easy-to-describe bijections between the Jacobian group of a regular matroid $M$ and bases of $M$, many instances of which are new even in the case of graphs. We first describe our family of bijections in a purely combinatorial way in terms of orientations; more specifically, we prove that the Jacobian group of $M$ admits a canonical simply transitive action on the set ${\mathcal{G}}(M)$ of circuit–cocircuit reversal classes of $M$, and then define a family of combinatorial bijections $\unicode[STIX]{x1D6FD}_{\unicode[STIX]{x1D70E},\unicode[STIX]{x1D70E}^{\ast }}$ between ${\mathcal{G}}(M)$ and bases of $M$. (Here $\unicode[STIX]{x1D70E}$ (respectively $\unicode[STIX]{x1D70E}^{\ast }$) is an acyclic signature of the set of circuits (respectively cocircuits) of $M$.) We then give a geometric interpretation of each such map $\unicode[STIX]{x1D6FD}=\unicode[STIX]{x1D6FD}_{\unicode[STIX]{x1D70E},\unicode[STIX]{x1D70E}^{\ast }}$ in terms of zonotopal subdivisions which is used to verify that $\unicode[STIX]{x1D6FD}$ is indeed a bijection. Finally, we give a combinatorial interpretation of lattice points in the zonotope $Z$; by passing to dilations we obtain a new derivation of Stanley’s formula linking the Ehrhart polynomial of $Z$ to the Tutte polynomial of $M$.

Whether monozygotic (MZ) and dizygotic (DZ) twins differ from each other in a variety of phenotypes is important for genetic twin modeling and for inferences made from twin studies in general. We analyzed whether there were differences in individual, maternal and paternal education between MZ and DZ twins in a large pooled dataset. Information was gathered on individual education for 218,362 adult twins from 27 twin cohorts (53% females; 39% MZ twins), and on maternal and paternal education for 147,315 and 143,056 twins respectively, from 28 twin cohorts (52% females; 38% MZ twins). Together, we had information on individual or parental education from 42 twin cohorts representing 19 countries. The original education classifications were transformed to education years and analyzed using linear regression models. Overall, MZ males had 0.26 (95% CI [0.21, 0.31]) years and MZ females 0.17 (95% CI [0.12, 0.21]) years longer education than DZ twins. The zygosity difference became smaller in more recent birth cohorts for both males and females. Parental education was somewhat longer for fathers of DZ twins in cohorts born in 1990–1999 (0.16 years, 95% CI [0.08, 0.25]) and 2000 or later (0.11 years, 95% CI [0.00, 0.22]), compared with fathers of MZ twins. The results show that the years of both individual and parental education are largely similar in MZ and DZ twins. We suggest that the socio-economic differences between MZ and DZ twins are so small that inferences based upon genetic modeling of twin data are not affected.

Lipid extracts from a 61.7-cm-long subtropical stalagmite in southern China, spanning the period of ca. 10,000–21,000 yr ago as constrained by U–Th dating, were analyzed using gas chromatography–mass spectrometry. The higher plants and microorganisms in the overlying soils contribute a proportion of n-alkanes identified in the stalagmite. The occurrence of LMW (lower molecular weight) n-alkanols and n-alkan-2-ones in the stalagmite was mainly related to the soil microorganisms. We suggest that HMW (higher molecular weight) n-alkanols and n-alkan-2-ones identified in the stalagmite originate from soil organics and reflect input from contemporary vegetation. Shifts in the ratio of LMW to HMW n-alkanols or n-alkan-2-ones indicative of the variation of soil ecosystems (e.g., microbial degradation of organic matter and/or the relative abundance of soil microorganisms to higher plants) are comparable with the subtropical alkenone-SST (sea surface temperature) record of the same period. The similar trends seen in the δ13C data and the lipid parameters in this stalagmite imply that the overlying soil ecosystem response to climate might be responsible for the variation of δ13C values.

Introduction: Despite the public health relevance of smoking in adolescents and emerging adults, this group remains understudied and underserved. High technology utilisation among this group may be harnessed as a tool for better understanding of smoking, yet little is known regarding the acceptability of mobile health (mHealth) integration.

Methods: Participants (ages 14–21 years) enrolled in a smoking cessation clinical trial provided feedback on their technology utilisation, perceptions, and attitudes; and interest in remote monitoring for smoking. Characteristics that predicted greater technology acceptability for smoking treatment were also explored.

Results: Participants (N = 87) averaged 19 years old and were mostly male (67%). Technology utilisation was high for smart phone ownership (93%), Internet use (98%), and social media use (94%). Despite this, only one-third of participants had ever searched the Internet for cessation tips or counselling (33%). Participants showed interest in mHealth-enabled treatment (48%) and felt that it could be somewhat helpful (83%). Heavier smokers had more favourable attitudes toward technology-based treatment, as did those with smartphones and unlimited data.

Conclusions: Our results demonstrate high technology utilisation, favourable attitudes towards technology, and minimal concerns. Technology integration among this population should be pursued, though in a tailored fashion, to accomplish the goal of providing maximally effective, just-in-time interventions.

A trend toward greater body size in dizygotic (DZ) than in monozygotic (MZ) twins has been suggested by some but not all studies, and this difference may also vary by age. We analyzed zygosity differences in mean values and variances of height and body mass index (BMI) among male and female twins from infancy to old age. Data were derived from an international database of 54 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins), and included 842,951 height and BMI measurements from twins aged 1 to 102 years. The results showed that DZ twins were consistently taller than MZ twins, with differences of up to 2.0 cm in childhood and adolescence and up to 0.9 cm in adulthood. Similarly, a greater mean BMI of up to 0.3 kg/m2 in childhood and adolescence and up to 0.2 kg/m2 in adulthood was observed in DZ twins, although the pattern was less consistent. DZ twins presented up to 1.7% greater height and 1.9% greater BMI than MZ twins; these percentage differences were largest in middle and late childhood and decreased with age in both sexes. The variance of height was similar in MZ and DZ twins at most ages. In contrast, the variance of BMI was significantly higher in DZ than in MZ twins, particularly in childhood. In conclusion, DZ twins were generally taller and had greater BMI than MZ twins, but the differences decreased with age in both sexes.

Karl Barth and Georges Florovsky interacted in several contexts, beginning in 1931 and then later within the ecumenical movement. Although some have noted a ‘Barthian’ accent in Florovsky's Christocentric theology, in fact both theologians remained critical of the other. Making use of extensive historical sources, this article attempts to reconstruct the meeting between Barth and Florovsky, and to pinpoint the areas of fundamental reservation and disagreement between the two. As will be shown, at the heart of their disagreement lay the role of eschatology in its impact on ecclesiology, a difference finally Christological in foundation. This fundamental disagreement shows itself likewise in relation to the two theologians' ideas concerning history, the relationship of philosophy to theology and the place of Hellenism in Church tradition. The role of Florovsky's opposition to the sophiology of Bulgakov in his interpretation of Barth, and Florovsky's stance vis-à-vis the debate between Barth and Brunner on natural theology, will also be considered. Uniquely, Florovsky anticipated the contemporary debate concerning Barth's doctrine of election, and drew crucial connections between Barth and Bulgakov on this point – an issue which for him was related to the question of the role of German Idealism in modern theology. Notwithstanding these disagreements, this article concludes by highlighting crucial areas of convergence between Barth and Florovsky concerning Christocentrism, revelation and theology as an enterprise in fides quaerens intellectum. Florovsky's ideas on analogy, naming and realism in theology will also be illumined, in relation to Barth and with reference to Bulgakov and Torrance.