The neuropsychiatric examination includes standard neurological and cognitive examination techniques with several additional observations and tasks designed to capture abnormalities common among patients with neuropsychiatric disorders or neurocognitive complaints. Although useful as a screening tool, a single standardized rating scale such as the Mini Mental State Examination (MMSE) or the Montreal Cognitive Assessment (MoCA) is insufficient to establish a neuropsychiatric diagnosis. Extra attention is paid to findings commonly seen in the setting of psychiatric disorders, dementias, movement disorders, or dysfunction of cortical or subcortical structures. Dysmorphic features, dermatologic findings, neurodevelopmental signs, signs of embellishment, and expanded neurocognitive testing are included. The neuropsychiatric clinician utilizes the techniques described in this article to adapt the examination to each patient’s situation, choosing the most appropriate techniques to supplement the basic neurological and psychiatric examinations in support of diagnostic hypotheses being considered. The added examination techniques facilitate diagnosis of neurocognitive disorders and enable neuropsychiatric formulation.

The immune response of mice experimentally infected with Echinococcus multilocularis metacestodes becomes impaired so as to allow parasite survival and proliferation. Our study tackled the question on how different classes of E. multilocularis antigens (crude vesicular fluid (VF); purified proteinic rec-14-3-3; purified carbohydrate Em2(G11)) are involved in the maturation process of bone-marrow-derived dendritic cells (BMDCs) and subsequent exposure to lymph node (LN) cells. In our experiments, we used BMDCs cultivated from either naïve (control) or alveolar echinococcosis (AE)-infected C57BL/6 mice. We then tested surface markers (CD80, CD86, MHC class II) and cytokine expression levels (interleukin (IL)-10, IL-12p40 and tumour necrosis factor (TNF)-α) of non-stimulated BMDCs versus BMDCs stimulated with different Em-antigens or lipopolysaccharide (LPS). While LPS and rec-14-3-3-antigen were able to induce CD80, CD86 and (to a lower extent) MHC class II surface expression, Em2(G11) and, strikingly, also VF-antigen failed to do so. Similarly, LPS and rec-14-3-3 yielded elevated IL-12, TNF-α and IL-10 expression levels, while Em2(G11) and VF-antigen didn't. When naïve BMDCs were loaded with VF-antigen, they induced a strong non-specific proliferation of uncommitted LN cells. For both, BMDCs or LN cells, isolated from AE-infected mice, proliferation was abrogated. The most striking difference, revealed by comparing naïve with AE-BMDCs, was the complete inability of LPS-stimulated AE-BMDCs to activate lymphocytes from any LN cell group. Overall, the presenting activity of BMDCs from AE-infected mice seemed to trigger unresponsiveness in T cells, especially in the case of VF-antigen stimulation, thus contributing to the suppression of clonal expansion during the chronic phase of AE infection.

Excess disability was examined in 17 nursing home residents with dementia by comparing their performance of morning care tasks under two activities of daily living (ADL) caregiving approaches—a dependence-supportive one under usual care and an independence-supportive one under functional rehabilitation. The results suggest that excess disability in severely cognitively impaired and functionally disabled residents can be reduced by increasing opportunities for independent activity, and substituting nondirective and directive verbal assists for physical assists. Further, the findings indicate that increased independence in ADL can be achieved without increasing disruptive behaviors and can foster appropriate requests for task-related help during caregiving. Functional rehabilitation, however, requires more time than usual care.

The ultrastructure of the septal pore cap (SPC) of Asterodon, Asterostroma and Coltricia were examined to establish the taxonomic position of these genera. Asterostroma has dolipores with perforate SPCs and is classified in the Lachnocladiaceae. In contrast, Asterodon and Coltricia have dolipores with imperforate SPCs and belong to the Hymenochaetaceae. Other selected species of genera belonging to the Hymenochaetaceae like Hydnochaete, Coltriciella, Inonotus, Onnia, and Cyclomyces also contained imperforate SPCs. Coltriciella, Inonotus and Cyclomyces moreover presented a lamella of endoplasmic reticulum above the imperforate SPC after chemical fixation. Such a lamella could rarely be observed in Coltricia only after high-pressure freezing and freeze substitution. Cryofixed fungal cells of Cyclomyces and Coltricia showed differences in the architecture of the matrix of the SPC. Coltricia showed a more layered matrix structure than the SPC of Cyclomyces. In addition, transmission- and scanning electron microscopy revealed an indent in the centre of the imperforate SPC of Cyclomyces, indicating a reduced thickness, and resulting into a tented profile in cross-sections.

Following the success of a simple shock model for outbursts in BL Lacertae and 3C 279 (see Aller, Aller & Hughes, this meeting) we have constructed computer codes to study in detail the radiation from shocked, relativistic jets. These codes compute the transfer of synchrotron radiation, accounting for polarized emission and absorption, rotation, and mode conversion for a turbulent collimated flow with one or more shocks propagating parallel to the jet axis. We present results for a flow that evolves adiabatically, with the turbulence represented by a random component to the magnetic field within each computational cell, and with the shocks prescribed analytically following Königl (Phys. Fluids, 23, 1083, 1980). From the evolution of the total and polarized fluxes as a function of frequency, and from the corresponding projection of the source structure on the plane of the sky, we see that this type of model

1. a. is capable o f explaining the variability of compact radio sources - see Aller, Aller & Hughes, this meeting,

2. b. highlights the care needed when interpreting VLBI maps, in that

   1. i) the component separations are frequency dependent (see Fig. 1)

   2. ii) the ‘core’ is not always the brightest component (see Fig. 1)

   3. iii) the Doppler boosting factor of the shocked flow is not directly related to the Lorentz factor derived from the apparent superluminal motion of a component

   4. iv) a multiplicity of components can give rise to both apparent contractions and accelerations,

3. c. clearly shows the link between time variability of compact sources and evolving VLBI structure, and suggests that both may be understood in terms of weak shocks that tap a small fraction of a jet's flow energy,

4. d. enables us to probe the physical conditions of the flow and the ambient material.

The behavior of the linear polarization of BL Lacertae during the recent series of radio bursts indicates the presence of Faraday rotation in the vicinity of the source and the formation of an axial compression in the radio jet.

Cm-wavelength observations of 15 BL Lac objects are presented. The degree of radio-wavelength variability is compared with the strength of the emission at optical and X-ray wavelengths.

Four sources have now been found by the Michigan variability program which exhibit large amplitude rotations in polarization position angle with time. The most straightforward explanation for the phenomenon is a physical rotation in the radio emitting region.

The present report is of the effect of variations of auditory input on hallucinatory experiences in seven schizophrenic patients. Nine experimental conditions, each of two minutes' duration, were compared with a control condition. At the end of each period subjects were required to rate the duration, loudness, and clarity of hallucinations during that time. Experimental conditions varied according to the amount of structure present in the material and in its attention-commanding properties. One condition required the active monitoring of material presented and resulted in the greatest decrease in hallucinatory experiences. For the passive conditions, findings were broadly consistent with predictions, indicating that it is not stimulation per se, but rather the extent to which structure is present and attended to, that is important in determining the occurrence of hallucinatory phenomena.

1. Serum ferritin concentrations were measured in 378 Zulu children aged 1–4 years living in Nqutu, KwaZulu and in 342 children of mixed race (Cape coloureds) aged between 1 and 16 years living near Johannesburg.

2. The pattern of serum ferritin concentrations encountered in the children at different ages tended to parallel the changes in iron stores which are known to occur during development.

3. Serum ferritin concentrations showed a significant direct correlation with age, haemoglobin, serum Fe and percentage saturation of transferrin values.

4. Anaemia was most prevalent in the younger children. Of the rural and urban children aged 13–24 months 60 and 53% respectively were anaemic while only 11% of those over 24 months had haemoglobin concentrations that were below normal.

5. The prevalence of anaemia among children who had serum ferritin values below 12 μg/l was only slightly higher than that for the groups as a whole (38.8 % v. 24.3%), while the prevalence in those with values of 12 μg/l or more was only slightly less (18.2%). However, when a ferritin concentration of less than 12μg/l was associated with a percentage saturation of transferrin of less than 16%, the prevalence of anaemia was 70.0%, and only 10.2% of children in whom both values were within the normal range were anaemic.

6. Since 67% of children had either a normal serum ferritin and a normal percentage saturation of transferrin or both values below the normal range, the two measurements taken together provided a useful means of separating the children who had significant Fe deficiency from those whose Fe stores were sufficient to make the appearance of anaemia unlikely.

The equilibrium probability distribution over the set of absorbing states of a reducible Markov chain is specified a priori and it is required to obtain the constrained sub-space or feasible region for all possible initial probability distributions over the set of transient states. This is called the inverse problem. It is shown that a feasible region exists for the choice of equilibrium distribution. Two different cases are studied: Case I, where the number of transient states exceeds that of the absorbing states and Case II, the converse. The approach is via the use of generalised inverses and numerical examples are given.