Hostname: page-component-848d4c4894-v5vhk Total loading time: 0 Render date: 2024-07-04T10:11:55.315Z Has data issue: false hasContentIssue false
  • English
  • Français

Serum ferritin as an index of iron nutrition in rural and urban South African children

Published online by Cambridge University Press:  24 July 2007

D. P. Derman ,
S. R. Lynch ,
T. H. Bothwell ,
R. W. Charlton ,
J. D. Torrance ,
B. A. Brink ,
G. M. Margo  and
J. Metz
D. P. Derman
Affiliation:
South African MRC Iron and Red Cell Metabolism Unit, Departments of Medicine and Pharmacology, University of the Witwatersrand, Johannesburg, South Africa
S. R. Lynch
Affiliation:
South African MRC Iron and Red Cell Metabolism Unit, Departments of Medicine and Pharmacology, University of the Witwatersrand, Johannesburg, South Africa
T. H. Bothwell
Affiliation:
South African MRC Iron and Red Cell Metabolism Unit, Departments of Medicine and Pharmacology, University of the Witwatersrand, Johannesburg, South Africa
R. W. Charlton
Affiliation:
South African MRC Iron and Red Cell Metabolism Unit, Departments of Medicine and Pharmacology, University of the Witwatersrand, Johannesburg, South Africa
J. D. Torrance
Affiliation:
South African MRC Iron and Red Cell Metabolism Unit, Departments of Medicine and Pharmacology, University of the Witwatersrand, Johannesburg, South Africa
B. A. Brink
Affiliation:
South African MRC Iron and Red Cell Metabolism Unit, Departments of Medicine and Pharmacology, University of the Witwatersrand, Johannesburg, South Africa
G. M. Margo
Affiliation:
Department of Haematology, School of Pathology, University of the Witwatersrand and South African Institute for Medical Research, Johannesburg, South Africa
J. Metz
Affiliation:
Department of Haematology, School of Pathology, University of the Witwatersrand and South African Institute for Medical Research, Johannesburg, South Africa
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Serum ferritin concentrations were measured in 378 Zulu children aged 1–4 years living in Nqutu, KwaZulu and in 342 children of mixed race (Cape coloureds) aged between 1 and 16 years living near Johannesburg.

2. The pattern of serum ferritin concentrations encountered in the children at different ages tended to parallel the changes in iron stores which are known to occur during development.

3. Serum ferritin concentrations showed a significant direct correlation with age, haemoglobin, serum Fe and percentage saturation of transferrin values.

4. Anaemia was most prevalent in the younger children. Of the rural and urban children aged 13–24 months 60 and 53% respectively were anaemic while only 11% of those over 24 months had haemoglobin concentrations that were below normal.

5. The prevalence of anaemia among children who had serum ferritin values below 12 μg/l was only slightly higher than that for the groups as a whole (38.8 % v. 24.3%), while the prevalence in those with values of 12 μg/l or more was only slightly less (18.2%). However, when a ferritin concentration of less than 12μg/l was associated with a percentage saturation of transferrin of less than 16%, the prevalence of anaemia was 70.0%, and only 10.2% of children in whom both values were within the normal range were anaemic.

6. Since 67% of children had either a normal serum ferritin and a normal percentage saturation of transferrin or both values below the normal range, the two measurements taken together provided a useful means of separating the children who had significant Fe deficiency from those whose Fe stores were sufficient to make the appearance of anaemia unlikely.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 39 , Issue 2 , March 1978 , pp. 383 - 389
Copyright
Copyright © The Nutrition Society 1978

References

REFERENCES

Addison, G. M., Beamish, M. R., Hales, C. N., Hodgkins, M., Jacobs, A. & Llewellin, P. (1972). J. clin. Path. 25, 326.Google Scholar
Bainton, D. F. & Finch, C. A. (1964). Am. J. Med. 37, 62.CrossRefGoogle Scholar
Bothwell, T. H. & Finch, C. A. (1962). Iron Metabolism, 1st ed. p. 210. London: J. and A. Churchill.Google Scholar
Cook, J. D., Alvarado, J., Gutnisky, A., Jamira, M., Labardini, J., Layrisse, M., Linares, J., Loria, A., Maspes, V., Restrepo, A., Reynafarje, C., Sánchez-Medal, L., Vélez, H. & Viteri, F. (1971). Blood 38, 591.CrossRefGoogle Scholar
Cook, J. D., Finch, C. A. & Smith, N. J. (1976). Blood 48, 449.CrossRefGoogle Scholar
Cook, J. D., Lipschitz, D. A., Miles, L. E. M. & Finch, C. A. (1974). Am. J. clin. Nutr. 27, 681.Google Scholar
Cowan, B. & Bharucha, C. (1973). Clinics in Haematology 2, 353.Google Scholar
Garby, L., Irnell, L. & Werner, I. (1969). Acta Med. scand. 185, 113.CrossRefGoogle Scholar
Hallberg, L. (1970). Iron Deficiency: Pathogenesis, Clinical Aspects, Therapy, p. 453 [Hallberg, L., Harwen, H-G and Vannotti, A., editors]. London and New York: Academic Press.Google Scholar
International Committee for, Standardization in Hematology (1971). Blood 37, 587.CrossRefGoogle Scholar
Jacobs, A., Miller, F., Worwood, M., Beamish, M. R. & Wardrop, C. A. (1972). Br. med. J. iv, 206.CrossRefGoogle Scholar
Lintzel, W., Rechenberger, J. & Schairer, E. (1944). Zr. ges. exp. Med. 113, 591.CrossRefGoogle Scholar
Lipschitz, D. A., Cook, J. D. & Finch, C. A. (1974). New Engl. J. Med. 290, 1213.CrossRefGoogle Scholar
Mann, H. B. & Whitney, D. R. (1947). Ann. math. Statist. 18, 50.CrossRefGoogle Scholar
Margo, G. M., Baroni, Y., Green, R. & Metz, J. (1977). Am. J. clin. Nutr. (In the Press.)Google Scholar
Margo, G. M., Baroni, Y., Wells, G., Green, R. & Metz, J. (1977). S. Afr. med. J. (In the Press.)Google Scholar
Miles, L. E. M., Lipschitz, D. A., Bieber, C. D. & Cook, J. D. (1974). Analyt. Biochem. 61, 209.CrossRefGoogle Scholar
Rios, E., Lipschitz, D. A., Cook, J. D. & Smith, N. J. (1975). Pediatrics, Springfield 55, 694.CrossRefGoogle Scholar
Siegel, S. (1956). Non-Parametric Statistics for the Behavioral Sciences (International Student Edition). Tokyo: McGraw-Hill, Kogakusha.Google Scholar
Siep, M. & Halvorsen, S. (1956). Acta Paediat. 45, 600.CrossRefGoogle Scholar
Siimes, M. A., Addiego, J. E. & Dallman, P. R. (1974). Blood 43, 581.CrossRefGoogle Scholar
Smith, N. J., Rosello, S., Say, M. B. & Yeys, K. (1955). Pediatrics, Springfield 16, 166.CrossRefGoogle Scholar
Walters, G. O., Miller, F. M. & Worwood, M. (1973). J. clin. Path. 26, 770.Google Scholar
WHO (1968). Tech. Rep. Ser. no. 405, 9.Google Scholar
Williams, H. L. & Conrad, M. E. (1972). Clinica chim. Acta 37, 131.Google Scholar
Wolstenholme, G. E. W. & O'Connor, M. (editors) (1966). Ethics in Medical Progress. London: J. and A. Churchill.Google Scholar