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6 results

  • Long-term global longitudinal strain abnormalities in paediatric patients after multisystem inflammatory syndrome in children correlate with cardiac troponin T: a single-centre cohort study

  • Stejara A. Netea, Giske Biesbroek, Maarten Groenink, R.N. (Nils) Planken, Robbert J. de Winter, Kawasaki Study Group, Nico A. Blom, Taco W. Kuijpers, Irene M. Kuipers
  • Journal:
    Cardiology in the Young , First View
    Published online by Cambridge University Press:
    08 April 2024, pp. 1-10
    • Article
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      • Open access
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  • Background:

    Multisystem inflammatory syndrome in children is an inflammatory syndrome related to severe acute respiratory syndrome coronavirus 2 with a high risk of cardiovascular complications (vasoplegia, cardiac shock). We investigated the cardiac outcomes in multisystem inflammatory syndrome in children, focusing on the identification of predictors for late cardiac function impairment.

    Methods:

    Clinical characteristics, conventional echocardiography (left ventricle ejection fraction, fractional shortening), 4-chamber left ventricular global longitudinal strain, and cardiac MRI of multisystem inflammatory syndrome in children patients (n = 48) were collected during admission, 6 weeks, 6 months, >12–≤18 months, and >18–≤24 months post-onset. Paired over-time patterns were assessed and multivariable regression analyses were performed to identify predictors for late global longitudinal strain impairment.

    Results:

    In total, 81.3% of patients had acute cardiac dysfunction (left ventricle ejection fraction <50% and/or fractional shortening <28%). The left ventricle ejection fraction and fractional shortening reached a plateau level ≤6 weeks, while the global longitudinal strain continued to decrease in the first 6 months post-onset (median –17.3%, P < 0.001 [versus acute]). At 6 months, 35.7% of the patients still had an abnormal global longitudinal strain, which persisted in 5/9 patients that underwent echocardiography >12–≤18 months post-onset and in 3/3 patients >18–≤24 months post-onset. In a multivariable analysis, soluble troponin T (>62.0 ng/L [median]) was associated with reduced global longitudinal strain at 6 months. Our cardiac MRI findings indicated acute myocardial involvement (increased T1/T2 value) in 77.8% (7/9), which recovered quickly without signs of fibrosis on convalescent cardiac MRIs.

    Conclusions:

    Late global longitudinal strain impairment is seen in some multisystem inflammatory syndrome in children patients up to one-year post-onset. Careful cardiac follow-up in patients with elevated troponin in the acute phase and patients with persistent abnormal global longitudinal strain is warranted until resolution of the global longitudinal strain since the long-term implications of such abnormalities are still unclear.

  • Next generation vitrification robot

  • Maarten Kuijper, Ivanka Spee, Adrian Koh, Daniel Němeček
  • Journal:
    Microscopy and Microanalysis / Volume 27 / Issue S1 / August 2021
    Published online by Cambridge University Press:
    30 July 2021, pp. 3252-3254
    Print publication:
    August 2021
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  • Cryo-EM Workflow Optimization

  • Maarten Kuijper, Merijn de Jonge, John Mitchels, Stan Konings, Ondrej Shanel, Rob van der Ploeg
  • Journal:
    Microscopy and Microanalysis / Volume 24 / Issue S1 / August 2018
    Published online by Cambridge University Press:
    01 August 2018, pp. 1124-1125
    Print publication:
    August 2018
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  • 7 - Bottom-up and top-down interactions in coastal interface systems

  • from Part II - Ecosystems
  • Edited by Torrance C. Hanley, Northeastern University, Boston, Kimberly J. La Pierre, University of California, Berkeley
  • Book:
    Trophic Ecology
    Published online:
    05 May 2015
    Print publication:
    07 May 2015, pp 157-200

  • Summary

    General introduction of rocky intertidal and salt marsh systems

    The land–sea margin encompasses a variety of hard and soft-bottom habitats where organisms are exposed to a dynamic range of aquatic and atmospheric conditions dependent on a rhythm set by the tides. In this chapter, we focus on rocky intertidal and salt marsh ecosystems, which have been extensively studied on many continents. Both rocky shore and salt marsh communities exhibit strong and consistent patterns of intertidal zonation over relatively compressed spatial scales, making them excellent systems for understanding the context-dependency of species interactions. Hard-bottomed rocky intertidal communities are dominated by marine macroalgae and sessile marine invertebrates extending their reach to the furthest edge of the influence of sea spray, while soft-bottomed salt marsh communities are anchored by terrestrial plants with adaptations or tolerance to inundation by salty and brackish waters. Rocky shore communities may be battered by the full force of large ocean waves or gently lapped with seawater on more protected shorelines. In contrast, salt marshes are restricted to quiet waters where sediment accretion by plants is the main mechanism for habitat creation. Both communities may experience very large tidal excursions or only minimal ones, depending on the local dynamics of the tides, with corresponding consequences for the spatial extent of these communities across the shoreline. The steep environmental gradients and distinctive biological zonation patterns that characterize both rocky shore and salt marsh ecosystems (Fig. 7.1) have provided ecologists with accessible and highly tractable ecosystems for investigating the role of bottom-up and top-down factors along environmental gradients.

    Bottom-up and top-down interactions in rocky intertidal systems

    Introduction to rocky intertidal systems

    Rocky intertidal communities have been the subject of intensive study world-wide, especially at temperate latitudes. The typically broad tidal range and relatively moderate atmospheric conditions create a wide zone of intertidal habitat that is generally hospitable to rocky intertidal species, while also readily accessible to investigators for hours at a time during periods of low tide and calm sea state.