To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure firstname.lastname@example.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Sustained volitional attention and working memory capacity was examined for the first time in people with Friedreich ataxia (FRDA). We administered subtests of the Test of Everyday Attention to 16 individuals with molecularly confirmed FRDA and gender-, age-, and IQ-matched controls. Clinically significant impairment in working memory and sustained volitional attention was evident. Working memory deficits correlated significantly with GAA repeat number on the shorter allele of the FXN gene, and separately, with disease severity, as measured by the Friedreich Ataxia Rating Scale score. Sustained volitional attention was not correlated with disease parameters, suggesting that this impairment may not be related to the disease process in a simple way. The deficits observed may be the result of disruption to corticocerebellar pathways, or directly related to the cortical and/or cerebellar pathology evident in people with FRDA. (JINS, 2011, 17, 000–000)
Patients with left spatial neglect following right
hemisphere damage may show anomalies in ipsilesional-limb
movements directed to targets on their affected side, in
addition to their characteristic perceptual deficits. In
this study we examined the extent to which visually guided
movements made by neglect patients are susceptible to interference
from concurrent visual distractors on the contralesional
or ipsilesional side of a designated target. Eleven right
hemisphere patients with visual neglect, plus 11 matched
healthy controls, performed a double-step movement task
upon a digitizing tablet, using their ipsilesional hand
to respond. On each double-step trial the first component
of the movement was cued to a common central target, whereas
the second component was cued unpredictably to a target
on either the contralesional or ipsilesional side. On separate
trials lateral targets either appeared alone or together
with a concurrent distractor in an homologous location
in the opposite hemispace. In addition to being significantly
slower and more error prone than controls, neglect patients
also exhibited a number of interference effects from ipsilesional
distractors. They often failed to move to left targets
in the presence of a right-sided distractor, or else they
moved to the distractor itself rather than to a contralesional
target. The initial accelerative phase of their movements
to contralesional targets tended to be interrupted prematurely,
and they spent significantly more time in the terminal
guidance phase of movements to contralesional targets in
the presence of an ipsilesional distractor. In contrast,
contralesional distractors had little effect on patients'
movements to ipsilesional targets. We conclude that right
hemisphere damage induces a competitive bias that favors
actions to ipsilesional targets. This bias affects multiple
stages of processing within the visuomotor system, from
initial programming through to the final stages of terminal
guidance. (JINS, 2001, 7, 334–343)
Email your librarian or administrator to recommend adding this to your organisation's collection.