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This study aimed to develop and evaluate a blind-deconvolution framework using the alternating direction method of multipliers (ADMMs) incorporated with weighted L1-norm regularization for light microscopy (LM) images. A presimulation study was performed using the Siemens star phantom prior to conducting the actual experiments. Subsequently, the proposed algorithm and a total generalized variation-based (TGV-based) method were applied to cross-sectional images of a mouse molar captured at 40× and 400× on-microscope magnifications and the results compared, and the resulting images were compared. Both simulation and experimental results confirmed that the proposed deblurring algorithm effectively restored the LM images, as evidenced by the quantitative evaluation metrics. In conclusion, this study demonstrated that the proposed deblurring algorithm can efficiently improve the quality of LM images.
To determine the influence of early pain relief for patients with suspected appendicitis on the diagnostic performance of surgical residents.
A prospective randomized, double-blind, placebo-controlled trial was conducted for patients with suspected appendicitis. The patients were randomized to receive placebo (normal saline intravenous [IV]) infusions over 5 minutes or the study drug (morphine 5 mg IV). All of the clinical evaluations by surgical residents were performed 30 minutes after administration of the study drug or placebo. After obtaining the clinical probability of appendicitis, as determined by the surgical residents, abdominal computed tomography was performed. The primary objective was to compare the influence of IV morphine on the ability of surgical residents to diagnose appendicitis.
A total of 213 patients with suspected appendicitis were enrolled. Of these patients, 107 patients received morphine, and 106 patients received placebo saline. The negative appendectomy percentages in each group were similar (3.8% in the placebo group and 3.2% in the pain control group, p=0.62). The perforation rates in each group were also similar (18.9% in the placebo group and 14.3% in the pain control group, p=0.75). Receiver operating characteristic analysis revealed that the overall diagnostic accuracy in each group was similar (the area under the curve of the placebo group and the pain control group was 0.63 v. 0.61, respectively, p=0.81).
Early pain control in patients with suspected appendicitis does not affect the diagnostic performance of surgical residents.
The ultraviolet (UV) color-color relation of early-type galaxies (ETGs) in the nearby universe (0.05 < z < 0.12) is re-examined with the latest GALEX GR6 and SDSS DR7 data. By drawing the FUV – NUV (as a measure of UV temperature) versus FUV – r (as a measure of UV amplitude) color-color diagram for the morphologically-cleaned, spectroscopically-cleaned sample of ~3700 quiescent ETGs, we find that the “old and dead“ ETGs consist of a well-defined sequence in UV colors, the “UV red sequence”, so that the stronger UV excess galaxies should have a harder UV spectral shape systematically. However, the observed UV spectral slope is too steep to be reproduced by the canonical models in which the UV flux is mainly controlled by age or metallicity parameters. The observed data support the helium enhancement scenario in which the UV spectral shape of UV upturn (FUV – NUV < 0.9; FUV – r ~ 6) galaxies may be governed by the minority population of helium-enhanced horizontal-branch (HB) stars.
Heat shock protein 70 (HSP70) is reported as the main factor responsible for the beneficial effects of glutamine (GLN) and as a negative regulator of high mobility group box protein-1 (HMGB-1) expression. Our aim was to determine whether GLN attenuates acute lung injury (ALI) by the inhibition of HMGB-1 expression during sepsis. Male Sprague–Dawley rats were subjected to caecal ligation and puncture (CLP) to induce sepsis. GLN or saline was administered through tail vein 1 h after CLP. Then, quercetin (Q), an inhibitor of HSP70, was utilised to assess the role of the enhanced HSP70. We observed the survival of the subjects. At 24 h post-CLP, we measured lung HSP70, phosphorylated heat shock factor-1 (HSF-1-p) and HMGB-1 expressions, NF-κB DNA-binding activity and ALI occurrence. We also measured serum HSP70, IL-6 and HMGB-1 concentrations. GLN improved survival during sepsis. In GLN-treated rats, lung HSP70 and HSF-1-p expressions were enhanced, lung HMGB-1 expression and NF-κB DNA-binding activity were suppressed, and ALI was attenuated. Furthermore, in GLN-administered rats, serum HSP70 concentration was higher, and serum IL-6 and HMGB-1 concentrations were lower than those in non-treated rats. Q inhibited the enhancement of HSP70 and HSF-1-p expressions and abrogated the GLN-mediated benefits. In conclusion, GLN attenuated ALI and improved survival by the inhibition of HMGB-1 expression during sepsis in rats. These benefits were associated with the enhancement of HSP70 expression by GLN.
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