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CHDs are the most common type of birth defect. One in four newborns with a heart defect has a critical CHD. In Mexico, there is a lack of data available to determine its prevalence. Pulse oximetry screening programmes have been implemented worldwide, reporting opportunity areas in algorithm interpretation and data management. Our study aims to share preliminary results of a 3-year experience of a multicentre pulse oximetry screening programme that addresses critical challenges.
Materials and methods:
This retrospective study examined the reports of newborns screened from February 2016 to July 2019 from five hospitals. Two algorithms –the New Jersey and the American Academy of Pediatrics– were implemented over consecutive periods. The algorithms’ impact was assessed through the calculation of the false-positive rate in an eligible population.
Results:
A total of 8960 newborns were eligible for the study; from it, 32.27% were screened under the New Jersey and 67.72% under the American Academy of Pediatrics algorithm – false-positive rate: 1% (CI 95: ± 0.36%) and 0.71% (CI 95: ± 0.21%), respectively. Seventy-nine newborns were referred, six were diagnosed with critical CHD, and six with CHD. The critical CHD estimated prevalence was 6.69:10,000 newborns (CI 95: ± 5.36). Our results showed that the algorithm was not related to the observable false-positive rate reduction.
Discussion:
Other factors may play a role in decreasing the false-positive rate. Our experience implementing this programme was that a systematic screening process led to more confident results, newborn’s report interpretation, and follow-up.
The way people with psychosis psychologically adapt and manage the diagnosis of such a mental disorder has been considered a key factor that contributes to the emergence and aggravation of emotional problems. These beliefs about illness can be very important due to their possible association with stigma and its implications in terms of loss of roles and social status. Given the importance of these personal beliefs about the specific diagnosis of psychosis, the Personal Beliefs about Illness Questionnaire (PBIQ) and PBIQ-R have been developed.
Aims:
The present study aims to explore the psychometric characteristics of the Spanish version of the PBIQ-R in a sample of patients with a diagnosis of psychosis-related disorders.
Method:
Participants were 155 patients (54.8% male) of the Public Health Service in Andalusia (Spain). Those who consented to participate filled in the PBIQ-R, the Social Comparison Scale, and the PHQ-9 and GAD-7 to measure emotional symptoms.
Results:
All dimensions showed adequate internal consistency values: Cronbach’s alpha extends between .81 and .88; and McDonald’s omega ranges between .87 and .92. The temporal reliability for an interval of 3–4 weeks was high. The correlations between the PBIQ-R dimensions and the other variables included in the study were significant and in the expected direction. The factor analysis of the principal components of the PBIQ-R dimensions revealed a single factor in each of the dimensions that explained 64–74%.
Conclusions:
The results support the reliability and validity of the Spanish version of the PBIQ-R.
OBJECTIVES/GOALS: The Title V Coop developed CRESCO, a physical and virtual space in the libraries of the two cooperating institutions. Adopting a flexible and transformational approach, it offers services to support the development of research and information skills of undergraduate students and faculty who receive clinical-translational research (CTR) training. METHODS/STUDY POPULATION: Since 2016, CRESCO has been staffed by a multidisciplinary team composed of three librarians, a statistician, an instructional designer, and an IT specialist. The physical facilities of the two libraries were remodeled and equipped, and a central portal was created to provide services and access to resources on a 7/24 basis. Online tutorials, workshops, and mentoring services have been offered that address topics in statistics, literature search, plagiarism, and the use of several research software. Services statistics are collected, and a questionnaire is administered to evaluate the workshops. RESULTS/ANTICIPATED RESULTS: The main results include 12 online tutorials created in CTR areas and available in the CRESCO hub portal; 14,660 mentoring/consultations offered in statistics, the use of research-related software, and the search for scientific literature search; and 6 online workshops created in CTR areas, with 463 attendees. When evaluating online workshops, participants considered that their acquired learning was high or extremely high on the following topics: use of Intellectus Statistics (88%, n = 96); selection of statistical tests (81%, n = 92); use of Turnitin (85%, n = 76); literature search (91%, n = 58); and citations and references in Mendeley (90%, n = 67). DISCUSSION/SIGNIFICANCE: These results suggest that the flexible, multidisciplinary, and transformational approach of CRESCO has been successful in helping undergraduate students and faculty develop the skills necessary to conduct CTR projects.
The present article aims to highlight methodological aspects related to understanding and conceptualising social capital for the purposes of population research as well as describing the key challenges in the harmonisation process of indicators of social capital. The study was conducted in the frame of the Ageing Trajectories of Health: Longitudinal Opportunities and Synergies (ATHLOS) project. After a review of social capital theories developed in social science and a subsequent review of the documentation of 18 international cohorts, decision trees of the harmonisation of social variables were developed. The known-group validity was verified. The results focused on generalised trust, civic engagement and social participation are presented. The summary of the availability of any indicators of these concepts is classified in seven domains (generalised trust, political participation, religious participation, senior-specific participation, participation in sport groups, participation in volunteer/charity group activities, any participation) across surveys. The results of the analysis for known-group validity support the construct validity of the harmonised variables.
More and more studies indicate that leisure plays a fundamental role in active ageing. Our study describes the current leisure patterns of older adults, comparing them with other age groups. Consequently, 445 adults, stratified by age (young, middle-aged and older adults), were selected and subsequently administered a set of tests. The results indicate that older people claim having more time for their leisure activities; however, the diversity of activities performed is lower, showing a negative gradient based on age. The leisure patterns of older people reflect a predominance of passive leisure, little cultural leisure time and moderate levels of social and physical leisure activities. Older people’s leisure seems to be influenced by ageist stereotypes and attribution biases. Our findings imply that these results could be used to design and implement programs aimed at promoting leisure styles that contribute to increase active ageing.
Data on short-term peripheral intravenous catheter–related bloodstream infections per 1,000 peripheral venous catheter days (PIVCR BSIs per 1,000 PVC days) rates from Latin America are not available, so they have not been thoroughly studied.
Methods:
International Nosocomial Infection Control Consortium (INICC) members conducted a prospective, surveillance study on PIVCR BSIs from January 2010 to March 2018 in 100 intensive care units (ICUs) among 41 hospitals, in 26 cities of 9 countries in Latin America (Argentina, Brazil, Colombia, Costa Rica, Dominican-Republic, Ecuador, Mexico, Panama, and Venezuela). The Centers for Disease Control and Prevention (CDC) National Health Safety Network (NHSN) definitions were applied, and INICC methodology and INICC Surveillance Online System software were used.
Results:
In total, 10,120 ICU patients were followed for 40,078 bed days and 38,262 PVC days. In addition, 79 PIVCR BSIs were identified, with a rate of 2.06 per 1,000 PVC days (95% confidence interval [CI], 1.635–2.257). The average length of stay (ALOS) of patients without a PIVCR BSI was 3.95 days, and the ALOS was 5.29 days for patients with a PIVCR BSI. The crude extra ALOS was 1.34 days (RR, 1.33; 95% CI, 1.0975–1.6351; P = .040).
The mortality rate in patients without PIVCR BSI was 3.67%, and this rate was 6.33% in patients with a PIVCR BSI. The crude extra mortality was 1.70 times higher. The microorganism profile showed 48.5% gram-positive bacteria (coagulase-negative Staphylococci 25.7%) and 48.5% gram-negative bacteria: Acinetobacter spp, Escherichia coli, and Klebsiella spp (8.5% each one), Pseudomonas aeruginosa (5.7%), and Candida spp (2.8%). The resistances of Pseudomonas aeruginosa were 0% to amikacin and 50% to meropenem. The resistance of Acinetobacter baumanii to amikacin was 0%, and the resistance of coagulase-negative Staphylococcus to oxacillin was 75%.
Conclusions:
Our PIVCR BSI rates were higher than rates from more economically developed countries and were similar to those of countries with limited resources.
This chapter offers a brief overview of the multiple transformations the island went through with the rise and fall of the colonial economy in the sixteenth century, as it cycled through gold extraction, and then the expansion of African slavery with the establishment of sugar plantations, all the while exploiting indigenous labor. After the decline of the sugar economy, ginger and cattle ranching followed as the most important economic activities in the last two decades of the century. The chapter ends with a description of the city of Santo Domingo as the social and political center of the colony.
During the final decades of the 1600s, French and Spanish residents in Hispaniola had developed a deeply ambivalent yet fluid relationship that ranged from the open violence to collaboration in their daily dealings. By the end of the century, however, Spanish residents on the island, especially in the north, came to rely on French merchants and settlers, who provided Hispaniola residents with a certain level of economic prosperity that legal (and illegal) Spanish traders operating in Santo Domingo could only provide at much higher prices and limited quantities. This rise of the intercolonial trade between both sides of the island happened as the efforts of the Spanish crown to eliminate French settlements from Hispaniola also increased. The participation of Spanish local residents in the war effort allowed them to manipulate the Spanish offensive and foil the imperial objective of consolidating Spanish control over all of Hispaniola, thus choosing the commercial benefits of accommodation to the neighboring French presence, despite the risks, instead of a safe reunification under Spanish control that would once again commercially isolate them.
This chapter analyzes the implementation of a plan the crown approved in August 1604 to depopulate by force the northern and western coasts of Hispaniola by destroying the existing villages and relocating their population to newly erected villages around Santo Domingo. The depopulations of Hispaniola were an attempt by the crown to impose order on a colony that in the previous two decades had been perceived as increasingly disorderly from the perspective of its extremely active contraband trade, but also from a social and religious perspective. Even though smuggling might have been the cause of the increasingly frequent alarms that reached Madrid during these years, the perception of religious and political impropriety, and the risks that these posed to the presumed religious purity and loyalty of Spanish vassals on the island might have been just as important (or arguably even more so) in spurring the Council of the Indies to action. This narrative, however, was fiercely challenged by the Hispaniola elites, who exculpated themselves of all wrongdoing while blaming any and all questionable behavior on landless peasants, whom they accused of leading all the smuggling efforts.
This chapter reveals the great level of control that local elites accumulated over both local and royal institutions in Santo Domingo, to expand their influence to other parts of the Spanish Caribbean and acquire a profitable network of associates and introduce contraband goods into the city. Rodrigo Pimentel’s political life provides an illuminating example of the particularities of Santo Domingo’s institutional life, but on a larger scale, it also reveals the profound limitations that the Spanish Monarchy’s bureaucratic apparatus had to govern its own Caribbean territories and, by extension, most of its colonial dominions beyond Mexico City and Lima. Under the Habsburg, colonial centers of royal authority, Audiencias and governors often became extensions of the communities that hosted ministers and royal officials, and not anchors of royal power in remote Spanish possessions, as the crown initially intended. In their dealings with high courts, these local groups of power both made and unmade the Spanish empire: they limited the influence of Madrid, but by using royal institutions for their own ends, they shaped the edges of the empire according to their own interests.
This chapter explores two complementary dimensions of acquisition and display of power by local elites in Santo Domingo. The first is political and institutional. In the early sevententh century, the sale of offices became standard practice in the Spanish empire allowing local elites to buy seats of regidores in local Cabildos across the empire in perpetuity, thus gaining control of their own local governments. A seat on the Cabildo of Santo Domingo became a prized possession for elites to reaffirm their position in the island social hierarchy. It also enabled access to important economic opportunities, which triggered rivalries among its members. The second one is also political, but it is more narrowly focused on racial politics, on the role of these elite men as slaveholders and the way they used their enslaved workers in their personal and political rivalries. The elites of Santo Domingo proudly manifested their power and tried to impose it upon their peers through their use of their enslaved workers, whose obedience (particularly when deployed in opposition to others) gave true meaning to the institutional and class power these elite men had acquired.
In the early days of 1694, tireless traveler Gregorio de Robles arrived at a bay on the northern coast of Hispaniola, where the town of Puerto Plata once stood. He journeyed on the ship of an asiento slave merchant, and once ashore, he encountered two Dutch sloops and an English one full of goods and openly trading. Locals had prepared 1,000 hides and the English and Dutch sailors went ashore “as if it was their own land,” ready to exchange their wares for all kinds of agricultural products. Robles suggested that this port needed to be better defended and that the city of Santiago should have a “good commander” because vigilance was crucial to protect the region. If Gregorio de Robles suspected that the local militias were involved in allowing this illicit trade, he was correct. Less than a century after the depopulations, the northern residents of Hispaniola had once again restored their transnational mercantile connections with the complicity of local militias and officials.