The efficacy of imazethapyr in drill-seeded imidazolinone-resistant rice was evaluated in Louisiana in 2000 and 2001. Imazethapyr was applied preemergence (PRE), or no PRE, followed by a postemergence (POST) application of imazethapyr alone, or in a mixture with bensulfuron, bentazon plus aciflurofen, carfentrazone, halosulfuron, propanil plus molinate, triclopyr, or V-10029. Imazethapyr applied PRE followed by a POST application of imazethapyr controlled barnyardgrass equivalent to or higher than other treatments evaluated. Red rice control at 35 days after postemergence treatment (DAT) was 66 to 81% with imazethapyr applied PRE followed by any POST application, but a reduction in control was observed with a POST application of imazethapyr. Although alligatorweed control increased with POST applications, these treatments suggested only suppression. Hemp sesbania control never exceeded 10% with imazethapyr-only treatments and at 35 DAT, all POST applications, except bensulfuron, increased control above 84%. Rice yield increased with treatments receiving a PRE application of imazethapyr compared with no imazethapyr applied PRE.