Oxygen isotope compositions of biogenic phosphates from mammals are widely used as proxies of the isotopic compositions of meteoric waters that are roughly linearly related to the air temperature at high- and mid-latitudes. An oxygen isotope fractionation equation was determined by using present-day European arvicoline (rodents) tooth phosphate: δ
18Op = 20.98(±0.59) + 0.572(±0.065) δ
18Ow. This fractionation equation was applied to the Late Pleistocene karstic sequence of Gigny, French Jura. Comparison between the oxygen isotope compositions of arvicoline tooth phosphate and Greenland ice core records suggests to reconsider the previously established hypothetical chronology of the sequence. According to the δ
18O value of meteoric water–mean air temperature relationships, the δ
18O value of arvicoline teeth records variations in mean air temperatures that range from 0° to 15°C.