In China, the public has gradually shifted their focus from GDP growth to quality-of-life issues, which imposes new challenges for the government. The food safety problem, as a salient issue, is one such example. This article analyzes how food safety problems affect ordinary Chinese people's trust in the government and their attribution of governmental responsibility using nationally representative survey data. As food safety risks are unequally distributed in China, the political impact of food safety problems varies among people of different socioeconomic statuses. The results show that food safety problems weaken the public's trust in both the central and local governments, but this negative effect is attenuated among people with a low level of education. Moreover, the Chinese public tends to attribute major responsibility to the central government rather than local governments when perceiving the severity of food safety problems, and this tendency becomes stronger for the low-income population. The results deepen the understanding of the local-central political trust patterns and the political implications of food safety problems in China.