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Chapter 7 - High-grade malignant epithelial tumors of the thymus: primary thymic carcinomas

Published online by Cambridge University Press:  05 February 2015

Mark R. Wick
Affiliation:
University of Virginia Health System
Alberto M. Marchevsky
Affiliation:
Cedars-Sinai Medical Center, Los Angeles
Saul Suster
Affiliation:
Medical College of Wisconsin
Alberto M. Marchevsky
Affiliation:
Cedars-Sinai Medical Center, Los Angeles
Mark R. Wick
Affiliation:
University of Virginia
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Publisher: Cambridge University Press
Print publication year: 2000

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References

Shimosato, Y, Kameya, T, Nagai, K, Suemasu, K: Squamous cell carcinoma of the thymus: An analysis of eight cases. Am J Surg Pathol 1977;1:109–21.CrossRefGoogle ScholarPubMed
Levine, GD, Rosai, J: Thymic hyperplasia and neoplasia: A review of current concepts. Hum Pathol 1978;9:495–515.CrossRefGoogle ScholarPubMed
Snover, DC, Levine, GD, Rosai, J: Thymic carcinoma: Five distinctive histological variants. Am J Surg Pathol 1982;6:451–70.CrossRefGoogle ScholarPubMed
Wick, MR, Weiland, LH, Scheithauer, BW, Bernatz, PE: Primary thymic carcinomas. Am J Surg Pathol 1982;6:612–30.CrossRefGoogle ScholarPubMed
Suster, S, Moran, CA: Thymic carcinoma: Spectrum of differentiation and histologic types. Pathology 1998;30:111–22.CrossRefGoogle ScholarPubMed
Iezzoni, IC, Nass, LB: Thymic basaloid carcinoma: A case report and review of the literature. Mod Pathol 1996;9:21–5.Google ScholarPubMed
Marino, M, Muller-Hermelink, HK: Thymoma and thymic carcinoma: Relation of thymoma epithelial cells to the cortical and medullary differentiation of thymus. Virchows Arch 1985;407:119–49.CrossRefGoogle ScholarPubMed
Suster, S: Thymic carcinoma: update of current diagnostic criteria and histologic types. Semin Diagn Pathol 2005;22:198–212.CrossRefGoogle ScholarPubMed
Chan, JKC, Tsang, WY, Seneviratne, S, Pau, MY: The MIC2 antibody 013: Practical application for the study of thymic epithelial tumors. Am J Surg Pathol 1995;19:1115–23.Google Scholar
Robertson, PB, Neiman, RS, Worapongpaiboon, S, et al.: 013 (CD99) positivity in hematologic proliferations correlates with TdT positivity. Mod Pathol 1997;10:277–82.Google Scholar
Suster, S, Moran, CA: Thymoma, atypical thymoma, and thymic carcinoma: A novel conceptual approach to the classification of neoplasms of thymic epithelium. Am J Clin Pathol 1999;111:826–33.CrossRefGoogle Scholar
Travis, WD, Brambilla, E, Muller-Hermelink, HK, et al. (Eds): Pathology & Genetics of Tumors of the Lung, Pleura, Thymus, & Heart. In: World Health Organization Classification of Tumors, Lyon, IARC Press, 2004.Google Scholar
Suster, S, Moran, CA: Primary thymic epithelial neoplasms with combined features of thymoma and thymic carcinoma: A clinicopathologic study of 22 cases. Am J Surg Pathol 1996;20:1469–80.CrossRefGoogle Scholar
Suster, S, Moran, CA: Primary thymic epithelial neoplasms: spectrum of differentiation & histologic features. Semin Diagn Pathol 1999;16:2–17.Google Scholar
Suster, S, Moran, CA: Thymic carcinoma: spectrum of differentiation and histologic types. Pathology 1998;30:111–22.CrossRefGoogle ScholarPubMed
Niehans, GA, Manivel, IC, Copland, GT, et al.: Immunohistochemistry of germ cell and trophoblastic neoplasms. Cancer 1988;62:1113–23.3.0.CO;2-0>CrossRefGoogle ScholarPubMed
Wick, MR, Simpson, RW, Niehans, GA, Scheithauer, BW: Anterior mediastinal tumors: A clinicopathologic study of 100 cases, with emphasis on immunohistochemical analysis. Prog Surg Pathol 1990;11:79–119.CrossRefGoogle Scholar
Moran, CA, Suster, S: Germ-cell tumors of the mediastinum. Adv Anat Pathol 1998;5:1–15.CrossRefGoogle ScholarPubMed
Suster, S, Moran, CA, Dominguez-Malagon, H, Quevedo-Blanco, P: Germ cell tumors of the mediastinum and testis: a comparative immunohistochemical study of 120 cases. Hum Pathol 1998;29;737–42.CrossRefGoogle ScholarPubMed
Tormoehlen, LM, Pascuzzi, RM: Thymoma, myasthenia gravis, and other paraneoplastic syndromes. Hematol Oncol Clin North Am 2008;22;509–26.CrossRefGoogle ScholarPubMed
Chan, JKC, Rosai, I: Tumors of the neck showing thymic or related branchial pouch differentiation: A unifying concept. Hum Pathol 1991;22:349–67.CrossRefGoogle ScholarPubMed
Leyvraz, S, Henle, W, Cahinian, AP, et al.: Association of Epstein-Barr virus with thymic carcinoma. N Engl J Med 1985;312:1296–9.CrossRefGoogle ScholarPubMed
Dimery, IW, Lee, JS, Blick, M, et al.: Association of the Epstein-Barr virus with lymphoepithelioma of the thymus. Cancer 1988;61:2475–80.3.0.CO;2-5>CrossRefGoogle ScholarPubMed
Wu, TC, Kuo, TT: Study of Epstein-Barr virus early RNA-1 (EBER1) expression by in-situ hybridization in thymic epithelial tumors of Chinese patients in Taiwan. Hum Pathol 1993;24:235–8.CrossRefGoogle ScholarPubMed
Chan, PC, Pan, CC, Yang, AH, et al.: Detection of Epstein-Barr virus genome within thymic epithelial tumors in Taiwanese patients with nested PCR, PCR in-situ hybridization, and RNA in-situ hybridization. J Pathol 2002;197:684–8.CrossRefGoogle Scholar
Engel, PJH: Absence of latent Epstein-Barr virus in thymic epithelial tumors as demonstrated by Epstein-Barr-encoded RNA (EBER) in-situ hybridization. APMIS 2000;108:393–7.CrossRefGoogle ScholarPubMed
Truong, LD, Mody, DR, Cagle, PT, et al.: Thymic carcinoma: a clinicopathologic study of 13 cases. Am J Surg Pathol 1990;14:151–66.CrossRefGoogle ScholarPubMed
Kuo, TT, Chang, JP, Lin, FJ, et al.: Thymic carcinomas: histopathologic varieties and immunohistochemical study. Am J Surg Pathol 1990;14:24–34.CrossRefGoogle Scholar
Chlabreysse, L, Etienne-Mastroianni, B, Adeleine, P, et al.: Thymic carcinoma: a clinicopathological and immunohistochemical study of 19 cases. Histopathology 2004;44:367–74.CrossRefGoogle Scholar
Shimosato, Y, Mukai, K: Tumors of the Mediastinum, In: Rosai, J (ed), Atlas of Tumor Pathology, Series 3, Fascicle 21, Washington, DC, Armed Forces Institute of Pathology, 1997;pp 33–273.Google Scholar
Weiss, LM, Gaffey, MI, Shibata, D: Lymphoepithelioma-like carcinoma and its relationship to Epstein-Barr virus. Am J Clin Pathol 1991;96:156–8.CrossRefGoogle ScholarPubMed
Tanaka, M, Shimokawa, R, Matsubara, O, et al.: Mucoepidermoid carcinoid of the thymic region. Acta Pathol Jpn 1982;32:703–12.Google Scholar
Moran, CA, Suster, S: Mucoepidermoid carcinoma of the thymus: A clinicopathologic study of six cases. Am J Surg Pathol 1995;19:826–34.CrossRefGoogle ScholarPubMed
Brightman, I, Morgan, JA, Kunze, WP, et al.: Primary mucoepidermoid carcinoma of the thymus: a rare cause of mediastinal tumor. Thorac Cardiovasc Surg 1991;40:90–1.CrossRefGoogle Scholar
Nonaka, D, Klimstra, D, Rosai, J: Thymic mucoepidermoid carcinomas: a clinicopathologic study of 10 cases and review of the literature. Am J Surg Pathol 2004;28:1526–31.CrossRefGoogle ScholarPubMed
Wolfe, JT, Wick, MR, Scheithauer, BW, Banks, PM: Clear cell carcinoma of the thymus. Mayo Clin Proc 1983;58:365–70.Google ScholarPubMed
Hasserjian, RP, Klimstra, DS, Rosai, J: Carcinoma of the thymus with clear cell features: report of eight cases and review of the literature. Am J Surg Pathol 1995;19:835–41.CrossRefGoogle ScholarPubMed
Stephens, M, Khalin, J, Gibbs, AR: Primary clear cell carcinoma of the thymus gland. Histopathology 1987;11:763–5.Google ScholarPubMed
Mattana, J, Jurtz, B, Miah, A, Singhal, PC: Renal cell carcinoma presenting as a solitary anterior superior mediastinal mass. J Med 1996;27:205–10.Google ScholarPubMed
Matsuno, Y, Morozumi, N, Hirohashi, S, et al.: Papillary carcinoma of the thymus: Report of four cases of a new microscopic type of thymic carcinoma. Am J Surg Pathol 1998;22:873–80.CrossRefGoogle ScholarPubMed
Makino, Y, Asada, M, Suzuki, T, et al.: A case of adenocarcinoma of the thymus. Jpn J Thorac Cardiovasc Surg 1998;46:1168–71.CrossRefGoogle ScholarPubMed
Weissferdt, A, Moran, CA: Thymic carcinoma associated with multilocular thymic cyst: a clinicopathologic study of 7 cases. Am J Surg Pathol 2011;35:1074–9.CrossRefGoogle ScholarPubMed
Kawashima, O, Kamiyoishihara, M, Skata, S, et al.: Basaloid carcinoma of the thymus. Ann Thorac Surg 1999;68:1863–5.CrossRefGoogle ScholarPubMed
Natsuo, T, Hayashida, R, Kobayashi, K, et al.: Thymic basaloid carcinoma with hepatic metastases. Ann Thorac Surg 2002;74:579–82.Google Scholar
Tanimura, S, Tomoyasu, H, Kohno, T, et al.: Basaloid carcinoma originating from the wall of a thymic cyst presenting as pericardial and thoracic effusion; report of a case. Kyobu Geka [Jpn J Thorac Surg] 2002;55:571–5.Google Scholar
Nishimura, M, Kodama, T, Nishiyama, H, et al.: A case of sarcomatoid carcinoma of the thymus. Pathol Int 1997;47:260–3.CrossRefGoogle ScholarPubMed
Suster, S, Moran, CA: Spindle-cell carcinoma: clinicopathologic and immunohistochemical study of a distinctive variant of primary thymic epithelial neoplasm. Am J Surg Pathol 1999;23:691–700.CrossRefGoogle ScholarPubMed
Paties, C, Zangrandi, A, Vassallo, G, et al.: Multidirectional carcinoma of the thymus with neuroendocrine and sarcomatoid components and carcinoid syndrome. Pathol Res Pract 1991;187:170–7.CrossRefGoogle ScholarPubMed
Eimoto, T, Kitaoka, M, Ogawa, H, et al.: Thymic sarcomatoid carcinoma with skeletal muscle differentiation: report of two cases, one with cytogenetic analysis. Histopathology 2002;40:46–57.CrossRefGoogle ScholarPubMed
Moritani, S, Ichihara, S, Mukai, K, et al.: Sarcomatoid carcinoma of the thymus arising in metaplastic thymoma. Histopathology 2008;52:409–11.CrossRefGoogle ScholarPubMed
Lu, HS, Gan, MF, Zhou, T, Wang, SZ:Sarcomatoid thymic carcinoma arising in metaplastic thymoma: a case report. Int J Surg Pathol 2011;19:677–80.CrossRefGoogle ScholarPubMed
Weissferdt, A, Moran, CA: Anaplastic thymic carcinoma: a clinicopathologic and immunohistochemical study of 6 cases. Hum Pathol 2012;43:874–7.CrossRefGoogle ScholarPubMed
Hsu, CP, Chen, CY, Chen, CL, et al.: Thymic carcinoma: ten years’ experience in twenty patients. J Thorac Cardiovasc Surg 1994;107:615–20.Google ScholarPubMed
Thomas-de-Montpréville, V, Ghigna, MR, et al.: Thymic carcinomas: clinicopathologic study of 37 cases from a single institution. Virchows Arch 2013;462:307–13.CrossRefGoogle ScholarPubMed
Falconieri, G, Moran, CA, Pizzolito, S, et al.: Intrathoracic rhabdoid carcinoma: a clinicopathologic, immunohistochemical, and ultrastructural study of 6 cases. Ann Diagn Pathol 2005;9:279–83.CrossRefGoogle Scholar
Moreira-deq-Ueiroga, E, Chikota, H, Bacchi, CE, et al.: Rhabdomyomatous carcinoma of the thymus. Am J Surg Pathol 2004;28:1245–50.CrossRefGoogle Scholar
Toprani, TH, Tamboli, P, Amim, MB, et al.: Thymic carcinoma with rhabdoid features. Ann Diagn Pathol 2003;7:106–11.CrossRefGoogle ScholarPubMed
Cavazza, A, Colby, TV, Tsokos, M, Rush, W, Travis, WD: Lung tumors with a rhabdoid phenotype. Am J Clin Pathol 1996;105:182–8.CrossRefGoogle ScholarPubMed
Gokden, N, Nappi, O, Swanson, PE, et al.: Renal cell carcinoma with rhabdoid features. Am J Surg Pathol 2000;34:1329–38.CrossRefGoogle Scholar
Choi, WWL, Lui, YH, Lau, WH, et al.: Adenocarcinoma of the thymus: report of two cases, including a previously-undescribed mucinous subtype. Am J Surg Pathol 2003;27:124–130.CrossRefGoogle ScholarPubMed
Takahashi, F, Tsuta, K, Matsuno, Y, et al.: Adenocarcinoma of the thymus: mucinous subtype. Hum Pathol 2005;36:219–23.CrossRefGoogle ScholarPubMed
Matsuno, Y, Mukai, K, Noguchi, M, et al.: Histochemical and immunohistochemical evidence of glandular differentiation in thymic carcinoma. Acta Pathol Jpn 1989;39:433–38.Google ScholarPubMed
Babu, MK, Nirmala, V: Thymic carcinoma with glandular differentiation arising in a congenital thymic cyst. J Surg Oncol 1994;57:277–9.CrossRefGoogle Scholar
Weissferdt, A, Moran, CA: Micronodular thymic carcinoma with lymphoid hyperplasia: a clinicopathological and immunohistochemical study of five cases. Mod Pathol 2012;25:993–9.CrossRefGoogle ScholarPubMed
Nonaka, D, Rodriguez, J, Rollo, JL, et al.: Undifferentiated large cell carcinoma of the thymus associated with Castleman-like reaction: a distinctive type of thymic neoplasm characterized by an indolent behavior. Am J Surg Pathol 2005;29:490–5.CrossRefGoogle Scholar
Suster, S, Moran, CA: Micronodular thymoma with lymphoid B-cell hyperplasia: clinicopathologic and immunohistochemical study of 18 cases of a distinctive variant of thymic epithelial neoplasm. Am J Surg Pathol 1999;23:955–62.CrossRefGoogle ScholarPubMed
Leong, ASY, Brown, JH: Malignant transformation in a thymic cyst. Am J Surg Pathol 1984;8:471–5.CrossRefGoogle Scholar
Fukayama, M, Nihei, Z, Takizawa, T, et al.: A case of squamous cell carcinoma of the thymus, probably originating from thymic cyst. Lung Cancer 1984;24:415–20.Google Scholar
Moran, CA, Suster, S: Thymic carcinoma: current concepts and histologic features. Hematol Oncol Clin North Am 2008;22:393–407.CrossRefGoogle ScholarPubMed
Haddad, H, Joudeh, A, El-Taani, H, et al.: Thymoma and thymic carcinoma arising in a thymolipoma: report of a unique case. Int J Surg Pathol 2009;17:55–9.CrossRefGoogle Scholar
Kuo, TT, Chan, JKC: Thymic carcinoma arising in thymoma is associated with alterations in immunohistochemical profile. Am J Surg Pathol 1998;22:1474–81.CrossRefGoogle ScholarPubMed
Finley, JL, Silverman, JF, Strausbauch, PH, et al.: Malignant thymic neoplasms: diagnosis by fine-needle aspiration biopsy with histologic, immunocytochemical, and ultrastructural confirmation. Diagn Cytopathol 1986;2:118–25.CrossRefGoogle ScholarPubMed
Kaw, YT, Esparza, AR: Fine needle aspiration cytology of primary squamous cell carcinoma of the thymus: a case report. Acta Cytol 1993;37:735–9.Google ScholarPubMed
Geisinger, KR. Differential diagnostic considerations and potential pitfalls in fine-needle aspiration biopsies of the mediastinum. Diagn Cytopathol 1995;13:436–42.CrossRefGoogle ScholarPubMed
Lucchi, M, Mussi, A, Ambrogi, M, et al.: Thymic carcinoma: a report of 13 cases. Eur J Surg Oncol 2001;27:636–40.CrossRefGoogle ScholarPubMed
Wakely, PE: Cytopathology-histopathology of the mediastinum: epithelial, lymphoproliferative, and germ cell neoplasms. Ann Diagn Pathol 2002;6:30–43.CrossRefGoogle ScholarPubMed
Wakely, PE Jr: Cytopathology of thymic epithelial neoplasms. Semin Diagn Pathol 2005;22:213–22.CrossRefGoogle ScholarPubMed
Assaad, MW, Pantanowitz, L, Otis, CN. Diagnostic accuracy of image-guided percutaneous fine needle aspiration biopsy of the mediastinum. Diagn Cytopathol 2007;35:705–9.CrossRefGoogle ScholarPubMed
Wakely, PEFine needle aspiration in the diagnosis of thymic epithelial neoplasms. Hematol Oncol Clin North Am 2008;22:433–42.CrossRefGoogle Scholar
Zakowski, MF, Huang, J, Bramlage, MP. The role of fine needle aspiration cytology in the diagnosis and management of thymic neoplasia. J Thorac Oncol 2010;5 (10 Suppl 4):S281–S285.CrossRefGoogle ScholarPubMed
Singhal, M, Lal, A, Srinivasan, R, Duggal, R, Khandelwal, N. Thymic carcinoma developing in a multilocular thymic cyst. J Thorac Dis 2012;4:512–15.Google Scholar
Posliqua, L, Ylagan, L: Fine-needle aspiration cytology of thymic basaloid carcinoma: case studies and review of the literature. Diagn Cytopathol 2006;34:358–66.CrossRefGoogle Scholar
Riazmontazer, N, Bedayat, C, Izadi, B: Epithelial cytologic atypia in a fine needle aspirate of an invasive thymoma: a case report. Acta Cytol 1992;36:387–90.Google Scholar
Walker, AN, Mills, SE, Fechner, RE: Thymomas and thymic carcinomas. Semin Diagn Pathol 1990;7:250–65.Google ScholarPubMed
Lauriola, L, Erlandson, RA, Rosai, J: Neuroendocrine differentiation is a common feature of thymic carcinoma. Am J Surg Pathol 1998;22:1059–66.CrossRefGoogle ScholarPubMed
Hishima, T, Fukayama, M, Hayashi, Y, et al.: Neuroendocrine differentiation in thymic epithelial tumors with special reference to thymic carcinoma and atypical thymoma. Hum Pathol 1998;29:330–8.CrossRefGoogle ScholarPubMed
Wick, MR, Ritter, JH, Dehner, LP: Malignant rhabdoid tumors: a clinicopathologic review and conceptual discussion. Semin Diagn Pathol 1995;12:233–48.Google ScholarPubMed
Kuzume, T, Kubonishi, I, Takeuchi, S, et al.: Establishment and characterization of a thymic carcinoma cell line (Ty-82) carrying t(15;19) (q15;p13) chromosome abnormality. Int J Cancer 1992;50:259–64.CrossRefGoogle Scholar
Kojika, M, Ishii, G, Yoshida, J, et al.: Immunohistochemical differential diagnosis between thymic carcinoma and type B3 thymoma: diagnostic utility of hypoxic marker, GLUT-1, in thymic epithelial neoplasms. Mod Pathol 2009;22:1341–50.CrossRefGoogle ScholarPubMed
Saad, RS, Landreneau, RJ, Liu, Y, et al.: Utility of immunohistochemistry in separating thymic neoplasms from germ cell tumors and metastatic lung cancer involving the anterior mediastinum. Appl Immunohistochem Mol Morphol 2003;11:107–12.CrossRefGoogle ScholarPubMed
Brown, JG, Bamiliari, U, Papotti, M, et al.: Thymic basaloid carcinoma: a clinicopathologic study of 12 cases, with a general discussion of basaloid carcinoma and its relationship with adenoid cystic carcinoma. Am J Surg Pathol 2009;33:1113–24.CrossRefGoogle ScholarPubMed
Rosai, J. The pathology of thymic neoplasia. Monogr Pathol 1987;29:161–83.Google Scholar
Pomplun, S, Wotherspoon, AC, Shah, G, et al.: Immunohistochemical markers in the differentiation of thymic and pulmonary neoplasms. Histopathology 2002;40:152–8.CrossRefGoogle ScholarPubMed
Weissferdt, A, Moran, CA: PAX8 expression in thymic epithelial neoplasms: an immunohistochemical analysis. Am J Surg Pathol 2011;35:1305–10.CrossRefGoogle ScholarPubMed
Laury, AR, Perets, R, Piao, H, et al.: A comprehensive analysis of PAX8 expression in human epithelial tumors. Am J Surg Pathol 2011;35:816–26.CrossRefGoogle ScholarPubMed
Wick, MR, Swanson, PE: “Carcinosarcomas:” current perspectives and an historical review of nosological concepts. Semin Diagn Pathol 1993;10:118–27.Google ScholarPubMed
Wick, MR: Immunohistology of neuroendocrine and neuroectodermal tumors. Semin Diagn Pathol 2000;17:194–203.Google ScholarPubMed
Dorfman, DM, Shahsafaei, A, Chan, JKC: Thymic carcinomas, but not thymomas and carcinomas of other sites, show CD5 immunoreactivity. Am J Surg Pathol 1997;21:936–40.CrossRefGoogle Scholar
Kornstein, MJ, Rosai, J: CD5 labeling of thymic carcinomas and other nonlymphoid neoplasms. Am J Clin Pathol 1998;109:722–6.CrossRefGoogle ScholarPubMed
Hishima, T, Fukayama, M, Fujisawa, M, et al.: CD5 expression in thymic carcinoma. Am J Pathol 1994;145:268–75.Google ScholarPubMed
Tateyama, H, Eimoto, T, Tada, T, et al.: Immunoreactivity of a new CD5 antibody with normal epithelium and malignant tumors, including thymic carcinomas. Am J Clin Pathol 1999;111:235–40.CrossRefGoogle Scholar
Berezowski, K, Grimes, MM, Gal, A, et al.: CD5 immunoreactivity of epithelial cells in thymic carcinoma and CASTLE using paraffin-embedded tissue. Am J Clin Pathol 1996;106:483–6.CrossRefGoogle ScholarPubMed
Hishima, T, Fukayama, M, Hayashi, Y, et al.: CD70 expression in thymic carcinoma. Am J Surg Pathol 2000;24:742–6.CrossRefGoogle ScholarPubMed
Pan, CC, Chen, PC, Chieng, H: Kit (CD117) is frequently overexpressed in thymic carcinomas but is absent in thymomas. J Pathol 2004;202:375–81.CrossRefGoogle ScholarPubMed
Schirosi, L, Nannini, N, Nicoli, D, et al.: Activating c-kit mutations in a subset of thymic carcinoma and response to different c-kit inhibitors. Ann Oncol 2012;23:2409–14.CrossRefGoogle Scholar
Miettinen, M, Lasota, J: Kit (CD117): a review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation. Appl Immunohistochem Mol Morphol 2005;13:205–20.CrossRefGoogle ScholarPubMed
Tateyama, H, Eimoto, T, Tada, T, et al.: p53 protein expression and p53 gene mutation in thymic epithelial tumors: an immunohistochemical and DNA sequencing study. Am J Clin Pathol 1995;104:375–81.CrossRefGoogle ScholarPubMed
Nino, H, Kondo, K, Miyoshi, T, et al.: High frequency of p53 protein expression in thymic carcinoma and atypical thymoma. Hum Pathol 1998;29:330–8.Google Scholar
Patton, DF, Ribeiro, RC, Jenkins, Jf, Sixbey, JW: Thymic carcinoma with a defective Epstein-Barr virus encoding the BZLFI trans-activator. J Infect Dis 1994;170:7–12.CrossRefGoogle ScholarPubMed
Dorfman, DM, Shahsafaei, A, Miyauchi, A: Immunohistochemical staining for bcl-2 and mcl-1 in intrathyroidal epithelial thymoma (ITET)/carcinoma showing thymus-like differentiation (CASTLE) and cervical thymic carcinoma. Mod Pathol 1998;11:989–94.Google ScholarPubMed
Vargas, SO, French, CA, Faul, PN, et al.: Upper respiratory tract carcinoma with chromosomal translocation 15;19. Evidence for a distinct disease entity of young patients with a rapidly fatal outcome. Cancer 2001;92:1195–1203.3.0.CO;2-3>CrossRefGoogle Scholar
Kees, UR, Mulcahy, MT, Willoughby, MLN: Intrathoracic carcinoma in an 11 year old girl showing a translocation t(15;19). Am J Ped Hematol Oncol 1991;13:459–64.CrossRefGoogle Scholar
Lee, ACW, Kwong, YI, Fu, KH, et al.: Disseminated mediastinal carcinoma with chromosomal translocation (15;19). A distinctive clinicopathologic syndrome. Cancer 1993;72:2273–6.3.0.CO;2-U>CrossRefGoogle ScholarPubMed
French, CA, Miyoshi, I, Aster, JC, et al.: BRD 4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol 2001;159:1987–92.CrossRefGoogle Scholar
French, CA. Pathogenesis of NUT midline carcinoma. Annu Rev Pathol 2012;7:247–65.CrossRefGoogle ScholarPubMed
French, CA. NUT midline carcinoma. Cancer Genet Cytogenet 2010;203:16–20.CrossRefGoogle ScholarPubMed
Petrini, P, French, CA, Rajan, A, et al.: NUT rearrangement is uncommon in human thymic epithelial tumors. J Thorac Oncol 2012;7:744–50.CrossRefGoogle ScholarPubMed
Evans, AG, French, CA, Cameron, MJ, et al.: Pathologic characteristics of NUT midline carcinoma arising in the mediastinum. Am J Surg Pathol 2012;36:1222–7.CrossRefGoogle ScholarPubMed
Bauer, DE, Mitchell, CM, Strait, KM, et al.: Clinicopathologic features and long-term outcomes of NUT midline carcinoma. Clin Cancer Res 2012;18:5773–9.CrossRefGoogle ScholarPubMed
Hayashi, S, Hamanaka, Y, Sueda, T, et al.: Thymic metastasis from prostatic carcinoma: Report of a case. Surg Today 1993;23:632–4.CrossRefGoogle ScholarPubMed
DeYoung, BR, Wick, MR: Immunohistologic evaluation of metastatic carcinomas of unknown origin: an algorithmic approach. Semin Diagn Pathol 2000;17:184–93.Google ScholarPubMed
Knapp, RH, Hurt, RD, Payne, WS, et al.: Malignant germ cell tumors of the mediastinum. J Thorac Cardiovasc Surg 1985;89:82–9.Google ScholarPubMed
Dehner, LP: Germ cell tumors of the mediastinum. Semin Diagn Pathol 1990;7:266–84.Google ScholarPubMed
Montresor, E, Nifosii, F, Lupi, A, et al.: Primary germinal tumors of the mediastinum. Chir Ital 1994;46:46–52.Google ScholarPubMed
Strickler, JG, Kurtin, PJ: Mediastinal lymphoma. Semin Diagn Pathol 1991;8:2–13.Google ScholarPubMed
Suster, S: Primary large-cell lymphomas of the mediastinum. Semin Diagn Pathol 1999;16:51–64.Google ScholarPubMed
Stanley, MW, Powers, CN: Syncytial variant of nodular sclerosing Hodgkin’s disease: fine-needle aspiration findings in two cases. Diagn Cytopathol 1997;17:477–9.3.0.CO;2-J>CrossRefGoogle ScholarPubMed
Pai, NB, Kim, S, Pathak, R, et al.: Syncytial variant of nodular sclerosing Hodgkin lymphoma. Lymphology 1999;32:75–9.Google ScholarPubMed
Park, IS, Kim, L, Han, JY, et al.: Syncytial variant of nodular sclerosis Hodgkin’s lymphoma assessed by fine needle aspiration cytology. Cytopathology 2008;19:394–397.CrossRefGoogle ScholarPubMed
Feldman, L, Kricun, ME: Malignant melanoma presenting as a mediastinal mass. JAMA 1979;241:396–7.CrossRefGoogle ScholarPubMed
Mackay, B, Lichteiger, B, Tessmer, CF, Chang, JP: The pathologic diagnosis of metastatic malignant melanoma. Cancer Bull 1971;23:30–45.Google Scholar
Prieto, VG, Shea, CR: Immunohistochemistry of melanocytic proliferations. Arch Pathol Lab Med 201;135:853–9.
Witkin, GB, Miettinen, M, Rosai, J: A biphasic tumor of the mediastinum with features of synovial sarcoma: a report of four cases. Am J Surg Pathol 1989;13:490–9.CrossRefGoogle ScholarPubMed
Trupiano, JK, Rice, TW, Herzog, K, et al.: Mediastinal synovial sarcoma: report of two cases with molecular genetic analysis. Ann Thorac Surg 2002;73:628–30.CrossRefGoogle ScholarPubMed
Yano, M, Toyooka, S, Tsukuda, K, et al.: SYT-SSX fusion genes in synovial sarcoma of the thorax. Lung Cancer 2004;44:391–7.CrossRefGoogle ScholarPubMed
Suster, S, Moran, CA. Primary synovial sarcomas of the mediastinum: a clinicopathologic, immunohistochemical, and ultrastructural study of 15 cases. Am J Surg Pathol 2005;29:569–78.CrossRefGoogle ScholarPubMed
Katakura, H, Fukuse, T, Shiraishi, I, et al.: Mediastinal synovial sarcoma. Thorac Cardiovasc Surg 2009;57:183–5.CrossRefGoogle ScholarPubMed
DeLeeuw, B, Suijkerbuijk, RF, Olde-Weghuis, D, et al.: Distinct Xpl1.2 breakpoint regions in synovial sarcoma revealed by metaphase and interphase FISH: Relationship to histologic subtypes. Cancer Genet Cytogenet 1994;73:89–94.CrossRefGoogle Scholar
Jo, VY, Fletcher, CDM: p63 immunohistochemical staining is limited in soft tissue tumors. Am J Clin Pathol 2011;136:762–6.CrossRefGoogle ScholarPubMed
Foo, WC, Cruise, MW, Wick, MR, Hornick, JL: Immunohistochemical staining for TLE1 distinguishes synovial sarcoma from histologic mimics. Am J Clin Pathol 2011;135:839–44.CrossRefGoogle ScholarPubMed
Shrivastava, CP, Devgarha, S, Ahlawat, V: Mediastinal tumors: a clinicopathological analysis. Asian Cardiovasc Thorac Ann 2006;14:102–4.CrossRefGoogle ScholarPubMed
Ng, CS, Munden, RF, Libshitz, HI: Malignant pleural mesothelioma: the spectrum of manifestations on CT in 70 cases. Clin Radiol 1999;54:415–21.CrossRefGoogle ScholarPubMed
Wick, MR, Mills, SE: Mesothelial proliferations: an increasing morphologic spectrum. Am J Clin Pathol 2000;113:619–22.CrossRefGoogle ScholarPubMed
Pan, CC, Chen, PC, Chou, TY, Chiang, H. Expression of calretinin and other mesothelioma-related markers in thymic carcinoma and thymoma. Hum Pathol 2003;34:1155–62.CrossRefGoogle ScholarPubMed
Masaoka, A, Monden, Y, Nakahara, K, et al.: Follow-up study of thymomas with special reference to their clinical stages. Cancer 1981;48:2485–92.3.0.CO;2-R>CrossRefGoogle ScholarPubMed
Blumberg, D, Burt, ME, Bains, MS, et al.: Thymic carcinoma: current staging does not predict prognosis. J Thorac Cardiovasc Surg 1998;115:303–8.CrossRefGoogle Scholar
Weissferdt, A, Moran, CA. Thymic carcinoma, part 1: a clinicopathologic and immunohistochemical study of 65 cases. Am J Clin Pathol 2012;138:103–14.CrossRefGoogle ScholarPubMed
Weissferdt, A, Moran, CA. Thymic carcinoma, part 2: a clinicopathologic correlation of 33 cases with a proposed staging system. Am J Clin Pathol 2012;138:115–21.CrossRefGoogle ScholarPubMed
Tsuchiya, R, Koga, K, Matsuno, Y, et al.: Thymic carcinoma: Proposal for pathological TNM and staging. Pathol Int 1994;44:505–12.CrossRefGoogle ScholarPubMed
Weide, LG, Ulbright, TM, Loehrer, PJ, Williams, SD. Thymic carcinoma. A distinct clinical entity responsive to chemotherapy. Cancer 1993;71:1219–23.3.0.CO;2-B>CrossRefGoogle Scholar
Chung, DA. Thymic carcinoma: analysis of nineteen clinicopathological studies. Thorac Cardiovasc Surg 2000;48:114–19.CrossRefGoogle ScholarPubMed
Suster, S, Rosai, J: Thymic carcinoma: a clinicopathologic study of 60 cases. Cancer 1991;67:1025–32.3.0.CO;2-F>CrossRefGoogle ScholarPubMed
Lin, JT, Wei-Shu, W, Yen, CC, et al.: Stage IV thymic carcinoma: a study of 20 patients. Am J Med Sci 2005;330:172–5.CrossRefGoogle ScholarPubMed
Bott, MJ, Wang, H, Travis, W, et al.: Management and outcomes of relapse after treatment for thymoma and thymic carcinoma. Ann Thorac Surg 2011;92:1984–91.CrossRefGoogle ScholarPubMed
Okuma, Y, Hosomi, Y, Takagi, Y, et al.: Clinical outcomes with chemotherapy for advanced thymic carcinoma. Lung Cancer 2013;80:75–80.CrossRefGoogle ScholarPubMed

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