This history from Creation to 1118, entitled Biblos Chronike, presents a highly theological view of human history. It has four books covering history from: 1) Creation to Adam, 2) Cain and Abel to Julius Caesar, 3) Caesar to Constantine, and 4) Constantine to the death of Alexios Komnenos in 1118. Glykas's history is ostensibly addressed to his son and makes occasional comments to a second- person reader throughout the text.

Book 1 begins with a “hexameron,” a discussion of nature and theology organized around explicating God's creation of the world in the first six days. This book is considerably longer than the other three and contains detailed discussions of cosmology, astronomy, natural history, and zoology. Glykas discusses the Hexameron of Basil of Caesarea and other classical and late antique naturalists and theologians. His work draws on a late antique bestiary known as the Physiologos.

Book 2 contains biblical history with a particular interest in the patriarchs’ knowledge of astrology and in theological questions. The reign of the Persian emperor Artaxerxes is identified as the era of “Sophocles, Heraclites, Anaxagoras, Pythagoras, Thucydides, Euripides, Herodotus, Empedocles, Diogenes, Hippocrates, Plato, and Aristotle.” The two subsequent paragraphs move from Alexander the Great to the revolt of the Maccabees.

Book 3 opens with a discussion of Julius Caesar's birth but soon turns to the life of Jesus. Most of the book describes the lives of Jesus and the apostles. The rest is comprised of brief paragraphs on the successive Roman emperors up to Aurelian, and then a race from Tacitus to Maximian in two paragraphs. Book 4 is a history of the emperors in Constantinople from Constantine up to Alexios Komnenos. A brief history of all eight ecumenical councils is inserted into the section on Justinian, but otherwise the narrative follows a clear chronological course. The pace slackens as Glykas moves into more contemporary history. For the reign of Alexios Komnenos he appears to follow the history of Zonaras. In keeping with his interest in natural history, particular attention is paid to unusual phenomena – effectively setting the history of the empire at Constantinople firmly into a cosmological history of divine economy.