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Chapter 23 - Movement disorders associated with neuromuscular disorders and peripheral neuropathies

from Section IV - Movement disorders in general neurology

Published online by Cambridge University Press:  05 April 2014

By
Philip D. Thompson
Edited by
Werner Poewe  and
Joseph Jankovic
Philip D. Thompson
Affiliation:
University Department of Medicine, University of Adelaide; Department of Neurology, Royal Adelaide Hospital, Adelaide, Australia
Werner Poewe
Affiliation:
Medical University Innsbruck
Joseph Jankovic
Affiliation:
Baylor College of Medicine, Texas
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Summary

Introduction

This chapter addresses the motor phenomena and involuntary movements that accompany peripheral neuropathies, mononeuropathies, neuromuscular junction disorders, and primary muscle disease. Spontaneous motor activity in peripheral neuropathies, such as fasciculation, fibrillation, myokymia, and neuromyotonia, is generated by ectopic discharges in motor axons and may present as cramps or muscle stiffness. Characteristic clinical and electromyographic features differentiate these syndromes from cramps that arise from metabolic or myotonic myopathies. Involuntary movements such as myoclonus or tremor occasionally accompany a neuropathy or peripheral nerve injury. The mechanisms whereby the altered peripheral signals recruit motor pathways in the central nervous system and generate these movements are complex and still poorly understood.

Myokymia and neuromyotonia in peripheral nerve hyperexcitability syndromes

The term “peripheral nerve hyperexcitability syndrome” (Hart et al. 2002) refers to continuous motor unit and muscle fibre activity generated by discharges in motor axons. The syndrome has been reported in the literature using descriptions of clinical phenomena interchangeably with electromyographic terminology (Thompson 1994; Thompson and Thomas 2005). Myokymia refers to clinically visible undulating, wave-like, or worm-like rippling of muscle and the electromyographic finding of continuous muscle activity with doublet, triplet, and multiple motor unit discharges. Myokymia is often accompanied by muscle fiber discharges, fasciculation, and repetitive trains of high frequency discharges described as “neuromyotonia.” This term was originally used to distinguish delayed muscle relaxation after voluntary contraction in peripheral nerve hyperexcitability syndromes from myotonia (caused by muscle fiber membrane hyperexcitability).

Type
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Information
Movement Disorders in Neurologic and Systemic Disease , pp. 352 - 362
Publisher: Cambridge University Press
Print publication year: 2014

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