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VIII.64 - Herpes Simplex

from Part VIII - Major Human Diseases Past and Present

Published online by Cambridge University Press:  28 March 2008

Kenneth F. Kiple
Affiliation:
Bowling Green State University, Ohio
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Summary

Herpes simplex is caused by Herpes virus hominis, of which there are two distinct serologic types designated as HSV-1 and HSV-2. The first mainly causes disease above the waist, such as cold sores; the second most commonly causes disease below the waist, especially genital herpes. Exceptions to this generalization occur especially among the newborn. The initial active phase is followed by prolonged latency. But the virus can be reactivated by another infection, stress, exposure to sunshine, or any number of other bodily changes.

Etiology and Epidemiology

The herpes viruses are visible in infected cells by electron microscopy and may be grown in the chick embryo, in tissue cultures, and in laboratory animals that react differently to types HSV-1 and HSV-2.

HSV-1 is shed from cells in the lacrimal and salivary glands, and both types are shed from the primary and recurrent lesions of the mucous membranes and skin. Samples of infected adults show that 2 to 4 percent are excreting the virus at a given time.

Infection with the herpes simplex virus results from person-to-person contact. HSV-1 infections commonly are transmitted by oral secretions through kissing or the sharing of eating utensils, and thus herpetic infection can easily be spread within a family. Normally HSV-1 infections are painful and bothersome but have no serious consequences. An exception can be when the virus invades the cornea of the eye. Conjunctival or corneal herpes may produce scars that impair vision. It may occur among wrestlers from skin-to-skin contact. Another form of HSV-1 infection, called herpetic paronychia, may occur in dentists and in hospital personnel.

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Publisher: Cambridge University Press
Print publication year: 1993

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References

Alibert, J. L. 1832. Monographic des dermatoses. Paris.Google Scholar
Bateman, Thomas. 1818. A practical synopsis of cutaneous diseases. Longman.Google Scholar
Baum, O. 1920. Ueber die Uebertragbarkeit des Herpes Simplex auf die Kaninchenhornhaut. Dermatologische Wochenschrift 70.Google Scholar
Bergh, R. 1890. Ueber Herpes Menstralis. Monatshefte für Praktische Dermatologie 10.Google Scholar
Beswick, T.S.L. 1962. The origin and the use of the word herpes. Medical History 6.CrossRefGoogle ScholarPubMed
Bierman, Stanley M. 1983. A retrospective study of 375 patients with genital herpes simplex infections seen between 1973 and 1980. Cutis 31.Google ScholarPubMed
Bolognese, R. J. 1976. Herpesvirus hominis type II infections in asymptomatic pregnant women. Obstetrics and Gynecology 48.Google ScholarPubMed
Corey, Lawrence. 1984. Genital herpes. In Sexually transmitted diseases, ed. Holmes, King K. et al. New York.Google Scholar
Dowdle, W. R., and Nahmias, A. J.. 1967. Association of antigenic type of herpes virus hominis with site of viral recovery. Journal of Immunology 99.Google ScholarPubMed
Duhring, Louis A. 1881. Discussion of Greenough paper. Archives of Dermatology 7.Google Scholar
Flexner, S., and Amos, H. L.. 1925. Contributions to the pathology of experimental encephalitis: II. Herpetic strains of encephalitogenic virus. Journal of Experimental Medicine 41.Google ScholarPubMed
Greenough, F. B. 1881. Herpes progenitalis. Archives of Dermatology 7.Google Scholar
Haeser, H. 1875. Lehrbuchgeschichte der Medizin und der epidemischen Krankheiten, 3 vols. Jena.Google Scholar
Hoeprich, P. D., ed. 1983. Infectious diseases, 3d edition. New York.Google Scholar
Holmes, King K., et al., eds. 1984. Sexually transmitted diseases. New York.Google ScholarPubMed
Kampmeier, R. H. 1984. Herpes genitalis: A clinical puzzle for two centuries. Sexually Transmitted Diseases 11.CrossRefGoogle ScholarPubMed
Legendre, F. L. 1853. Mémoire sur l’herpes de la vulve. Archives Générales de Médecine 2.Google Scholar
Levin, E. 1906. Ueber Herpes bein Frauen und seine Beziehungen zur Menstruation. Deutsche Medizinische Wochenschrift 26: ;.Google Scholar
Lipschütz, B. 1921. Untersuchungen uber die Aetiologie der Krankheiten den Herpesgruppe (Herpes zoster, Herpes genitalis, Herpes febrilis). Archiv fur Dermatologie und Syphilis 136.Google Scholar
Morton, R. S. 1975. Herpes genitalis. In Recent advances in sexually transmitted diseases, ed. Morton, R. S. and Harris, J. R. W.. London.Google Scholar
Nahmias, A. J., Alford, C. A., and Sheldon, B. K.. 1970. Infection of the newborn with Herpes virus hominis. Advances in Pediatrics 17.Google Scholar
Nahmias, A. J., and Campbell, Donald E.. 1983. Infections caused by herpes simplex viruses. In Infectious diseases, ed. Hoeprich, Paul D., 3d ed. Philadelphia.Google Scholar
Nahmias, A. J., Keyserling, H. L., and Kerrick, G. M.. 1983. Herpes simplex virus. In Infectious diseases of the fetus and newborn infants, ed. Remington, J. and Klein, J. O., 2d ed. Philadelphia.Google Scholar
Nahmias, A. J., et al. 1969. Genital infection with type 2 herpes virus hominis: A commonly occurring venereal disease. British Journal of Venereal Diseases 45.Google ScholarPubMed
Nahmias, A. J., et al. 1981. Clinical aspects of infection with herpes simplex viruses 1 and 2. In The human herpesviruses, ed. Nahmias, Andre J., Dowdle, Walter R., and Schinazi, Raymond F.. New York.Google Scholar
Preuss, J. 1978. Biblical and Talmudic medicine (1911). New York.Google Scholar
Rapp, Fred, ed. 1984. Herpesviruses: Proceedings of a Burroughs Wellcome–UCLA Symposium, April, 1984.Google Scholar
Rawls, W. E., et al. 1971. Genital herpes in two social groups. American Journal of Obstetrics and Gynecology 110.CrossRefGoogle ScholarPubMed
Sabin, Albert B., Bond, A., and Wright, A. M.. 1934. Acute ascending myelitis following a monkey bite, with isolation of a virus capable of reproducing the disease. Journal of Experimental Medicine 59.CrossRefGoogle ScholarPubMed
Schneweiss, K. E. 1962. Serologische Untersuchungen zur Typendifferenzierung des Herpesvirus Hominis. Zeitschrift fur Immunitdtsforschung und Experimentelle Therapie 124.Google Scholar
,U.S. Public Health Service. 1984. Morbidity and Mortality Weekly Report. Annual Summary, March 33.
Unna, P. G. 1883. On herpes progenitalis, especially in women. Journal of Cutaneous and Venereal Diseases 1.Google Scholar
Willan, Robert. 1808. On Cutaneous Diseases, Vol. 1. London.Google Scholar

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  • Herpes Simplex
  • Edited by Kenneth F. Kiple, Bowling Green State University, Ohio
  • Book: The Cambridge World History of Human Disease
  • Online publication: 28 March 2008
  • Chapter DOI: https://doi.org/10.1017/CHOL9780521332866.126
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  • Herpes Simplex
  • Edited by Kenneth F. Kiple, Bowling Green State University, Ohio
  • Book: The Cambridge World History of Human Disease
  • Online publication: 28 March 2008
  • Chapter DOI: https://doi.org/10.1017/CHOL9780521332866.126
Available formats
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  • Herpes Simplex
  • Edited by Kenneth F. Kiple, Bowling Green State University, Ohio
  • Book: The Cambridge World History of Human Disease
  • Online publication: 28 March 2008
  • Chapter DOI: https://doi.org/10.1017/CHOL9780521332866.126
Available formats
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