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Chapter 1 - Liver development

from Section I - Pathophysiology of pediatric liver disease

Published online by Cambridge University Press:  05 March 2014

By
Yiwei Zong  and
Joshua R. Friedman
Edited by
Frederick J. Suchy ,
Ronald J. Sokol  and
William F. Balistreri
Yiwei Zong
Affiliation:
Department of Strategic Management, China Resources, China
Joshua R. Friedman
Affiliation:
Perelman School of Medicine at the University of Pennsylvania, Division of Gastroenterology, Hepatology, and Nutrition, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
Frederick J. Suchy
Affiliation:
University of Colorado Medical Center
Ronald J. Sokol
Affiliation:
University of Colorado Medical Center
William F. Balistreri
Affiliation:
University of Cincinnati College of Medicine
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Summary

Introduction

Liver development requires two linked processes: differentiation of the various hepatic cell types from their embryonic progenitors and the arrangement of those cells into structures that permit the distinctive circulatory, metabolic, and excretory functions of the liver.

Primarily through the use of rodent, fish, and frog model systems, many essential regulators of liver development have been identified. These include extracellular signaling molecules, intracellular signal transduction pathways, and transcription factors. In recent years, transcriptional regulation by microRNA has also been implicated in liver development. In addition, a class of biliary diseases associated with defects in the cholangiocyte cilium has highlighted the importance of this structure in bile duct morphology and cellular polarity.

This chapter describes the stages of liver development in conjunction with their associated molecular pathways. Whenever relevant, links to pediatric liver disease will be indicated. One important insight that has emerged from the study of liver development is that the process is not complete at birth, because bile duct remodeling is ongoing (see below). In addition, it has become clear that many of the molecular pathways that direct liver development are reactivated during the course of liver regeneration. Therefore insights derived from the embryonic and fetal liver may be relevant in the context of liver injury at any age.

Type
Chapter
Information
Liver Disease in Children , pp. 1 - 9
Publisher: Cambridge University Press
Print publication year: 2014

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  • Liver development
    • By Yiwei Zong, Department of Strategic Management, China Resources, China, Joshua R. Friedman, Perelman School of Medicine at the University of Pennsylvania, Division of Gastroenterology, Hepatology, and Nutrition, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
  • Edited by Frederick J. Suchy, University of Colorado Medical Center, Ronald J. Sokol, University of Colorado Medical Center, William F. Balistreri
  • Book: Liver Disease in Children
  • Online publication: 05 March 2014
  • Chapter DOI: https://doi.org/10.1017/CBO9781139012102.002
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  • Liver development
    • By Yiwei Zong, Department of Strategic Management, China Resources, China, Joshua R. Friedman, Perelman School of Medicine at the University of Pennsylvania, Division of Gastroenterology, Hepatology, and Nutrition, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
  • Edited by Frederick J. Suchy, University of Colorado Medical Center, Ronald J. Sokol, University of Colorado Medical Center, William F. Balistreri
  • Book: Liver Disease in Children
  • Online publication: 05 March 2014
  • Chapter DOI: https://doi.org/10.1017/CBO9781139012102.002
Available formats
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To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Liver development
    • By Yiwei Zong, Department of Strategic Management, China Resources, China, Joshua R. Friedman, Perelman School of Medicine at the University of Pennsylvania, Division of Gastroenterology, Hepatology, and Nutrition, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
  • Edited by Frederick J. Suchy, University of Colorado Medical Center, Ronald J. Sokol, University of Colorado Medical Center, William F. Balistreri
  • Book: Liver Disease in Children
  • Online publication: 05 March 2014
  • Chapter DOI: https://doi.org/10.1017/CBO9781139012102.002
Available formats
×