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Chap. 26 - SKIN SIGNS OF SYSTEMIC NEOPLASTIC DISEASES AND PARANEOPLASTIC CUTANEOUS SYNDROMES

Published online by Cambridge University Press:  07 September 2011

Kyrill Pramatarov
Affiliation:
University Hospital Lozenetz
Ronni Wolf
Affiliation:
Kaplan Medical Center, Rehovot, Israel
Batya B. Davidovici
Affiliation:
Kaplan Medical Center, Rehovot, Israel
Jennifer L. Parish
Affiliation:
Jefferson Medical College of Thomas Jefferson University
Lawrence Charles Parish
Affiliation:
Jefferson Medical College of Thomas Jefferson University
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Summary

THE SKIN MAY reflect many visceral diseases, malignancies included. Sometimes, the skin may even give a clue to the underlying neoplasm. The French dermatologist Delacrétaz has definded the term “paraneoplasia:”

Cutaneous paraneoplastic syndromes are nonmetastatic manifestations on the skin as a result of the existence of a malignant visceral tumor and/or disease of the lymphoma group, especially leukaemias. The close relation between the dermatosis and tumor is confirmed by the phenomenon of disappearance or not at all influenced skin disease, if the malignant tumor is eliminated by operation, irradiation or cytostatics. The recurrence of the skin changes (dermatosis) indicates a relapse of the tumor or metastases.

The paraneoplastic signs or syndromes may precede, appear parallel to, or follow the appearance of the internal malignancy. There are many classifications of the paraneoplastic signs and syndromes, utilizing a variety of criteria: Some of them are based on the morphology of skin changes, others are based on the frequency of the association of dermatosis/visceral malignancy. The paraneoplastic signs and syndromes may be divided into two groups: indirect associations and direct associations with parallel evolutions corresponding to the paraneoplastic syndrome. The pathogenesis of the development of paraneoplasias include:

  • peptides, mediators, and hormones released from the tumor;

  • immunological defense reactions induced by the tumor antigens and appearing after cross-reaction with the structures of the skin;

  • deposits of immunocomplexes of tumor antigens and antibodies; and

  • various cytokines and possibly growth factors.

Type
Chapter
Information
Emergency Dermatology , pp. 265 - 270
Publisher: Cambridge University Press
Print publication year: 2011

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References

Delacretaz, J.Nouveaux syndromes paraneoplasiques cutanes. Med Hyg Geneve. 1967; 25:1005–6.Google Scholar
Vlckova-Laskovska, MT, Balabanova-Stefanova, MG, Caca-Biljanovska, NG. Cutaneous paraneoplastic syndromes. Bull CEEDVA. 2004; 6:13–16.Google Scholar
Balo-Banga, JM, Vajda, A. Paraneoplastic disorders and syndromes of the skin. Bull CEEDVA. 2004; 6:4–12.Google Scholar
Thomas, I, Schwartz, R. Cutaneous paraneoplastic syndromes: uncommon presentations. Clin Dermatol. 2005; 23:593–600.CrossRefGoogle ScholarPubMed
Powell, F, Cooper, A, Massa, M, et al. Sister Mary Joseph's nodule: a clinical and histologic study. J Am Acad Dermatol. 1984; 10:610–15.CrossRefGoogle ScholarPubMed
Andreev, V, Boyanov, L, Tsankov, N. Generalized acanthosis nigricans. Dermatologica. 1981; 163:19–24.CrossRefGoogle ScholarPubMed
Balo-Banga, JM, Racz, I, Szalay, F, et al. Ein mit Castleman-to-Rhino Hamarton einhergehende paraneoplastischer Symptomenkomplex. Z Hautkr. 1990; 65:761.Google Scholar
Wareing, MJ, Vaughan-Jones, SA, McGibbon, DH. Acrokeratosis paraneoplastica: Bazes syndrome. J Laryng Otolog. 1996; 110:899–900.CrossRefGoogle Scholar
Sarkar, B, Knecht, R, Sarkar, C, et al. Bazex syndrome acrokeratosis paraneoplastica. Eur Archiv Oto-Rhino-Laringol. 1998; 255:205–10.CrossRefGoogle ScholarPubMed
Eubanks, , McBurney, E, Reed, R. Erythema gyratum repens. Am J Med Sci. 2001; 321:302–5.CrossRefGoogle ScholarPubMed
Holt, PJA, Davies, MG. Erythema gyratum repens – an immunologically mediated dermatosis. Br J Dermatol. 1977; 96:343–7.CrossRefGoogle ScholarPubMed
Gantcheva, M, Tsankov, N, Pramatarov, K. Erythema gyratum repens without internal malignancy. J Eur Acad Dermatol Venereol. 1995; 5:67–9.CrossRefGoogle Scholar
Lynch, MT, Linch, PM, Pester, J, et al. The cancer family syndrome: rare cutaneous phenotypic linkage of Torre's syndrome. Arch Intern Med. 1981; 141:607–11.CrossRefGoogle ScholarPubMed
Suspiro, A, Fidalgo, P, Crovo, M, et al. The Muir-Torre syndrome: a rare variant of hereditary nonpolyposis colorectal cancer associated with hMSH2 mutation. Am J Gastroenterol. 1998; 93:1572–4.CrossRefGoogle ScholarPubMed
Rampen, HJ, Schwengle, . The sign of Leser – Trelat: does it exist. J Am Acad Dermatol. 1989; 21:50–5.CrossRefGoogle ScholarPubMed
Schwartz, RA. The sign of Leser – Trelat. J Am Acad Dermatol. 1996; 35:88–95.CrossRefGoogle ScholarPubMed
Santacroce, L, Gagliardi Abraham, M. Clucagonoma e Medicine. Endocrinology 2007 Feb 9
Cohen, PR, Talpaz, M, Kurzrock, R. Malignancy-associated Sweet's syndrome: review of the world literature. J Clin Oncol. 1988; 6:1887–97.CrossRefGoogle ScholarPubMed
Zappasodi, P, Del Forno, C, Corso, A, et al. Mucocutaneous paraneoplastic syndromes in hematologic malignancies. Int J Dermatol. 2006; 45:14–20.CrossRefGoogle ScholarPubMed
Anhalt, GJ.Paraneoplastic pemphigus: the role of tumors and drugs. Br J Dermatol. 2001; 144:1101–4.CrossRefGoogle ScholarPubMed
Vassileva, S, Drenovska, K, Serafimova, D, et al. Paraneoplastic pemphigus: report of two cases associated with chronic lymphocytic leukemia. Bull CEEDVA. 2004; 6:17–22.Google Scholar
Callen, JP, Woo, TY. Vesiculopustular eruption in a patient with ulcerative colitis. Arch Dermatol. 1985; 121:399–403.CrossRefGoogle Scholar
Kurzrock, R, Cohen, PR. Mucocutaneous paraneoplastic manifestations in hematologic malignancy. Am J Med. 1995; 92:207–16.CrossRefGoogle Scholar
Maoz, CR, Langevitz, P, Livneh, A, et al. High incidence of malignancies in patients with dermatomyositis and polymyositis: an 11-year analysis. Semin Arthritis Rheum. 1998; 27:319–24.CrossRefGoogle ScholarPubMed
Bernard, P, Bonnetblanc, JM. Dermatomyositis and malignancy. J Invest Dermatol. 1993; 100:128–32.CrossRefGoogle ScholarPubMed
Sridhar, KS, Lobo, CF, Altman, RD. Digital clubbing and lung cancer. Chest. 1998; 114:1535–7.CrossRefGoogle ScholarPubMed
Macedo, AG, Fusari, VC, Paes del Almeida, JR, et al. Digital clubbing as the initial diagnosis of bronchogenic cancer. Anais Brasil Dermatol. 2004; 79:457–62.CrossRefGoogle Scholar
Breathnach, SM, Wells, GC. Acantosis nigricans: tripe palms. Clin Exp Dermatol. 1980; 5:181–9.CrossRefGoogle Scholar
Sanchez-Guerrero, J, Gutierrez-Urena, S, Vidaller, A, et al. Vasculitis as a paraneoplastic syndrome: report of 11 cases and review of the literature. J Rheumatol. 1990; 17:1458–62.Google ScholarPubMed
Federman, D, Brescia, G, Horne, M, et al. Cutaneous manifestation of malignancy. Postgrad Med Online. 2004; 115:1–13.Google Scholar
Cohen, P.Granuloma annulare, relapsing polychondritis, sarcoidosis, and systemic lupus erythematosus: conditions whose dermatologic manifestation may occur as hematologic malignancy – associated mucocutaneous paraneoplastic syndromes. Int J Dermatol. 2006; 45:70–80.CrossRefGoogle Scholar
Schepers, C, Malvehy, J, Azon-Masoliver, A, et al. Papuloerythroderma of Ofuji: a report of 2 cases including the first European case associated with visceral carcinoma. Dermatology. 1996; 193:131–5.CrossRefGoogle ScholarPubMed
Nishijima, S.Papuloerythroderma associated with hepatocellular carcinoma. Br J Dermatol. 1998; 139:1115–16.CrossRefGoogle ScholarPubMed
Kempf, W, Kutzner, H, Kettelhack, N, et al. Paraneoplastic pityriasis lichenoides in cutaneous lymphoma: case report and review of the literature on paraneoplastic reactions of the skin in lymphoma and leukemia. Br J Dermatol. 2005; 152:1327–31.CrossRefGoogle Scholar
Chan, LS, Hanson, CA, Cooper, KD. Eosinophilic fasciitis as a paraneoplastic syndrome. Arch Dermatol. 1991; 127:862–5.CrossRefGoogle ScholarPubMed
Vottery, R, Biswas, G, Deshmukh, C, et al. Scleroderma and dermographism in a case of carcinoma ovary. Indian J Dermatol Venereol Leprol. 2005; 71:429–30.Google Scholar
Lazarov, A, Lalkin, A, Cordoba, M, et al. Paraneoplastic pityriasis lichenoides chronica. J Eur Acad Dermatol Venereol. 1999; 12:189–90.CrossRefGoogle ScholarPubMed

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