With advances in perioperative care, major liver resections are being increasingly performed for primary and metastatic liver tumors. Although fatal liver failure and major technical complications are now rare after resection, complications associated with cholestasis, fluid retention and impaired synthetic function still contribute to protracted recovery time and extended hospital stay (1, 2). Although the risk for perioperative liver failure is multifactorial, one of the most important factors associated with this complication is the volume of the liver remaining after surgery. Patients considered at high risk are those with normal underlying liver in whom more than 80% of the functional liver mass will be removed or those with chronic liver disease who undergo resection of more than 60% of their functional liver mass (2–5).

One strategy used to improve the safety of extensive liver surgery in patients with small remnant livers is preoperative portal vein embolization (PVE) (5–15). PVE redirects portal flow to the intended future liver remnant (FLR) in an attempt to initiate hypertrophy of the non-embolized segments, and PVE has been shown to improve the functional reserve of the FLR before surgery. In appropriately selected patients, PVE can reduce perioperative morbidity and allow for safe, potentially curative hepatectomy for patients previously considered ineligible for resection based on anticipated small remnant livers (5–15). For this patient subset, PVE is now utilized as the standard of care at many comprehensive hepatobiliary centers prior to major hepatectomy.