Skip to main content Accessibility help
×
Hostname: page-component-77c89778f8-cnmwb Total loading time: 0 Render date: 2024-07-16T10:30:59.313Z Has data issue: false hasContentIssue false

3 - Multi-detector row computed tomography (MDCT) techniques for imaging pancreatic neoplasms

Published online by Cambridge University Press:  23 December 2009

Jay Heiken
Affiliation:
Mallinckrodt Institute of Radiology
Get access

Summary

Introduction

From the earliest clinical experiences with single slice computed tomography (CT) to today's multi-detector row CT (MDCT) era, it has been apparent that successful imaging detection of pancreatic neoplasms is significantly improved by the use of pancreas-specific examination protocols [1]. The primary goal in imaging patients suspected of a pancreatic neoplasm is to confidently detect or exclude its presence. If a pancreatic neoplasm is found, the imaging study should provide an accurate assessment of the parameters that will allow appropriate treatment selection for each patient. This chapter examines in detail the specific elements that comprise an MDCT pancreatic protocol. Radiologists reading this chapter will be able to adapt these recommended imaging parameters to their own site. Non-radiologist clinicians will gain a sense of the strengths and limitations of properly performed MDCT scanning for pancreatic disease and will be encouraged to make the radiologist aware of the clinical suspicion such that the patient can be examined with the best possible technique.

The pancreatic protocol used at our institution will be reviewed with emphasis on how each element of the protocol improves imaging accuracy. Although the primary focus will be on the evaluation of pancreatic ductal adenocarcinoma, we will also explore specific utility for neuroendocrine tumors and cystic pancreatic neoplasms.

MDCT pancreatic protocol components

A well-designed imaging protocol must specify the types of patients for whom the protocol is appropriate, provide the technologist with appropriate acquisition parameters, and take into consideration the radiation dose delivered to the patient.

Type
Chapter
Information
Pancreatic Cancer , pp. 28 - 45
Publisher: Cambridge University Press
Print publication year: 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Megibow, AJ.Pancreatic adenocarcinoma: designing the examination to evaluate the clinical questions. Radiology 1992; 183(2): 297–303.CrossRefGoogle ScholarPubMed
Mahesh, M.Search for isotropic resolution in CT from conventional through multiple-row detector. Radiographics 2002; 22(4): 949–962.CrossRefGoogle ScholarPubMed
Itoh, S, Ikeda, M, Ota, T, et al. Assessment of the pancreatic and intrapancreatic bile ducts using 0.5-mm collimation and multiplanar reformatted images in multislice CT. Eur Radiol 2003; 13(2): 277–285.Google ScholarPubMed
Brenner, DJ, Hall, EJ. Computed tomography – an increasing source of radiation exposure. N Engl J Med 2007; 357(22): 2277–2284.CrossRefGoogle ScholarPubMed
Dalrymple, NC, Prasad, SR, El-Merhi, FM, Chintapalli, KN. Price of isotropy in multidetector CT. Radiographics 2007; 27(1): 49–62.CrossRefGoogle Scholar
Winter, TC, Ager, JD, Nghiem, HV, et al. Upper gastrointestinal tract and abdomen: water as an orally administered contrast agent for helical CT. Radiology 1996; 201(2): 365–370.CrossRefGoogle ScholarPubMed
Megibow, AJ, Babb, JS, Hecht, EM, et al. Evaluation of bowel distention and bowel wall appearance by using neutral oral contrast agent for multi-detector row CT. Radiology 2006; 238(1): 87–95.CrossRefGoogle ScholarPubMed
Mitka, M.Milk shows potential as CT contrast agent. JAMA 2007; 297(4): 353.Google ScholarPubMed
Horton, KM, Fishman, EK. MDCT of the duodenum: technique and clinical applications. Crit Rev Comput Tomogr 2004; 45(5–6): 309–334.CrossRefGoogle ScholarPubMed
House, MG, Yeo, CJ, Cameron, JL, et al. Predicting resectability of periampullary cancer with three-dimensional computed tomography. J Gastrointest Surg 2004; 8(3): 280–288.CrossRefGoogle ScholarPubMed
Megibow, AJ, Jacob, G, Heiken, JP, et al. Quantitative and qualitative evaluation of volume of low osmolality contrast medium needed for routine helical abdominal CT. Am J Roentgenol 2001; 176(3): 583–589.CrossRefGoogle ScholarPubMed
Yanaga, Y, Awai, K, Nakayama, Y, et al. Pancreas: patient body weight tailored contrast material injection protocol versus fixed dose protocol at dynamic CT. Radiology 2007; 245(2): 475–482.CrossRefGoogle ScholarPubMed
Kim, T, Murakami, T, Takahashi, S, et al. Pancreatic CT imaging: effects of different injection rates and doses of contrast material. Radiology 1999; 212(1): 219–225.CrossRefGoogle ScholarPubMed
Tublin, ME, Tessler, FN, Cheng, SL, Peters, TL, McGovern, PC. Effect of injection rate of contrast medium on pancreatic and hepatic helical CT. Radiology 1999; 210(1): 97–101.CrossRefGoogle ScholarPubMed
Schueller, G, Schima, W, Schueller-Weidekamm, C, et al. Multidetector CT of pancreas: effects of contrast material flow rate and individualized scan delay on enhancement of pancreas and tumor contrast. Radiology 2006; 241(2): 441–448.CrossRefGoogle ScholarPubMed
Ichikawa, T, Erturk, SM, Sou, H, et al. MDCT of pancreatic adenocarcinoma: optimal imaging phases and multiplanar reformatted imaging. Am J Roentgenol 2006; 187(6): 1513–1520.CrossRefGoogle ScholarPubMed
Diehl, SJ, Lehmann, KJ, Sadick, M, Lachmann, R, Georgi, M.Pancreatic cancer: value of dual-phase helical CT in assessing resectability. Radiology 1998; 206(2): 373–378.CrossRefGoogle ScholarPubMed
McNulty, NJ, Francis, IR, Platt, JF, et al. Multi-detector row helical CT of the pancreas: effect of contrast-enhanced multiphasic imaging on enhancement of the pancreas, peripancreatic vasculature, and pancreatic adenocarcinoma. Radiology 2001; 220(1): 97–102.CrossRefGoogle ScholarPubMed
Fletcher, JG, Wiersema, MJ, Farrell, MA, et al. Pancreatic malignancy: value of arterial, pancreatic, and hepatic phase imaging with multi-detector row CT. Radiology 2003; 229(1): 81–90.CrossRefGoogle ScholarPubMed
Imbriaco, M, Megibow, AJ, Camera, L, et al. Dual-phase versus single-phase helical CT to detect and assess resectability of pancreatic carcinoma. Am J Roentgenol 2002; 178(6): 1473–1479.CrossRefGoogle ScholarPubMed
Johnson, TR, Krauss, B, Sedlmair, M, et al. Material differentiation by dual energy CT: initial experience. Eur Radiol 2007; 17(6): 1510–1517.CrossRefGoogle ScholarPubMed
Francis, IR.Pancreatic adenocarcinoma: diagnosis and staging using multidetector-row computed tomography (MDCT) and magnetic resonance imaging (MRI). Cancer Imaging 2007; 7 Spec No A: S160–S165.CrossRefGoogle Scholar
Tunaci, M.Multidetector row CT of the pancreas. Eur J Radiol 2004; 52(1): 18–30.CrossRefGoogle ScholarPubMed
Prokesch, RW, Schima, W, Chow, LC, Jeffrey, RB.Multidetector CT of pancreatic adenocarcinoma: diagnostic advances and therapeutic relevance. Eur Radiol 2003; 13(9): 2147–2154.CrossRefGoogle ScholarPubMed
Fishman, EK, Horton, KM.Imaging pancreatic cancer: the role of multidetector CT with three-dimensional CT angiography. Pancreatology 2001; 1(6): 610–624.CrossRefGoogle ScholarPubMed
Kim, HC, Yang, DM, Jin, W, et al. Multiplanar reformations and minimum intensity projections using multi-detector row CT for assessing anomalies and disorders of the pancreaticobiliary tree. World J Gastroenterol 2007; 13(31): 4177–4184.CrossRefGoogle ScholarPubMed
Lu, DS, Reber, HA, Krasny, RM, Kadell, BM, Sayre, J.Local staging of pancreatic cancer: criteria for unresectability of major vessels as revealed by pancreatic-phase, thin-section helical CT. Am J Roentgenol 1997; 168(6): 1439–1443.CrossRefGoogle ScholarPubMed
Raptopoulos, V, Steer, ML, Sheiman, RG, et al. The use of helical CT and CT angiography to predict vascular involvement from pancreatic cancer: correlation with findings at surgery. Am J Roentgenol 1997; 168(4): 971–977.CrossRefGoogle Scholar
Fishman, EK, Horton, KM, Urban, BA.Multidetector CT angiography in the evaluation of pancreatic carcinoma: preliminary observations. J Comput Assist Tomogr 2000; 24(6): 849–853.CrossRefGoogle ScholarPubMed
Nakayama, Y, Yamashita, Y, et al. Vascular encasement by pancreatic cancer: correlation of CT findings with surgical and pathologic results. J Comput Assist Tomogr 2001; 25(3): 337–342.CrossRefGoogle ScholarPubMed
Vargas, R, Nino-Murcia, M, Trueblood, W, Jeffrey, RB, Jr. MDCT in pancreatic adenocarcinoma: prediction of vascular invasion and resectability using a multiphasic technique with curved planar reformations. Am J Roentgenol 2004; 182(2): 419–425.CrossRefGoogle Scholar
Li, H, Zeng, MS, Zhou, KR, Jin da, Y, Lou, WH.Pancreatic adenocarcinoma: the different CT criteria for peripancreatic major arterial and venous invasion. J Comput Assist Tomogr 2005; 29(2): 170–175.CrossRefGoogle ScholarPubMed
Li, H, Zeng, MS, Zhou, KR, Jin, da Y, Lou, WH.Pancreatic adenocarcinoma: signs of vascular invasion determined by multi-detector row CT. Br J Radiol 2006; 79(947): 880–887.CrossRefGoogle ScholarPubMed
Zamboni, GA, Kruskal, JB, Vollmer, CM, et al. Pancreatic adenocarcinoma: value of multidetector CT angiography in preoperative evaluation. Radiology 2007; 245(3): 770–778.CrossRefGoogle ScholarPubMed
Yamada, Y, Mori, H, et al. CT assessment of the inferior peripancreatic veins: clinical significance. Am J Roentgenol 2000; 174(3): 677–684.CrossRefGoogle ScholarPubMed
Hough, TJ, Raptopoulos, V, Siewert, B, Matthews, JB.Teardrop superior mesenteric vein: CT sign for unresectable carcinoma of the pancreas. Am J Roentgenol 1999; 173(6): 1509–1512.CrossRefGoogle ScholarPubMed
Hommeyer, SC, Freeny, PC, Crabo, LG.Carcinoma of the head of the pancreas: evaluation of the pancreaticoduodenal veins with dynamic CT – potential for improved accuracy in staging. Radiology 1995; 196(1): 233–238.CrossRefGoogle ScholarPubMed
Lepanto, L, Arzoumanian, Y, Gianfelice, D, et al. Helical CT with CT angiography in assessing periampullary neoplasms: identification of vascular invasion. Radiology 2002; 222(2): 347–352.CrossRefGoogle ScholarPubMed
Gangi, S, Fletcher, JG, Nathan, MA, et al. Time interval between abnormalities seen on CT and the clinical diagnosis of pancreatic cancer: retrospective review of CT scans obtained before diagnosis. Am J Roentgenol 2004; 182(4): 897–903.CrossRefGoogle ScholarPubMed
Procacci, C, Biasiutti, C, Carbognin, G, et al. Spiral computed tomography assessment of resectability of pancreatic ductal adenocarcinoma: analysis of results. Dig Liver Dis 2002; 34(10): 739–747.CrossRefGoogle Scholar
Nino-Murcia, M, Tamm, EP, Charnsangavej, C, Jeffrey, RB, Jr. Multidetector-row helical CT and advanced postprocessing techniques for the evaluation of pancreatic neoplasms. Abdom Imaging 2003; 28(3): 366–377.CrossRefGoogle ScholarPubMed
Roche, CJ, Hughes, ML, Garvey, CJ, et al. CT and pathologic assessment of prospective nodal staging in patients with ductal adenocarcinoma of the head of the pancreas. Am J Roentgenol 2003; 180(2): 475–480.CrossRefGoogle ScholarPubMed
Smith, SL, Basu, A, Rae, DM, Sinclair, M.Preoperative staging accuracy of multidetector computed tomography in pancreatic head adenocarcinoma. Pancreas 2007; 34(2): 180–184.CrossRefGoogle ScholarPubMed
McMahon, PM, Halpern, EF, Fernandez-del, Castillo C, Clark, JW, Gazelle, GS.Pancreatic cancer: cost-effectiveness of imaging technologies for assessing resectability. Radiology 2001; 221(1): 93–106.CrossRefGoogle ScholarPubMed
ED, Rappeport, Hansen, CP, Kjaer, A, Knigge, U.Multidetector computed tomography and neuroendocrine pancreaticoduodenal tumors. Acta Radiol 2006; 47(3): 248–256.Google Scholar
Sahani, DV, Kadavigere, R, Blake, M, et al. Intraductal papillary mucinous neoplasm of pancreas: multi-detector row CT with 2D curved reformations – correlation with MRCP. Radiology 2006; 238(2): 560–569.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×