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26 - MiRNAs in glioblastoma

from V - MicroRNAs in disease biology

Published online by Cambridge University Press:  22 August 2009

Silvia Anna Ciafrè
Affiliation:
Experimental Medicine and Biochemical Sciences University of Rome Via Montpellier 1, Rome 00133 Italy
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Summary

Introduction

Glioblastoma multiforme: a lethal brain tumor still missing a thorough comprehension of molecular oncogenesis

Glioblastoma multiforme (GBM) is one of the most lethal forms of cancers and the most common brain tumor in adults, accounting for approximately 12%–15% of all intracranial neoplasms and 50%–60% of all astrocytic tumours (Zhu and Parada, 2002; Hulleman and Helin, 2005). In most European and North American countries, incidence is approximately 2–3 new cases per 100 000 people per year. Composed of poorly differentiated neoplastic astrocytes, glioblastomas are located preferentially in the subcortical white matter of the cerebral hemispheres, and either may develop from lower grade astrocytic tumors (secondary or progressive glioblastoma multiforme) or may arise very rapidly de novo (primary glioblastoma multiforme) (Wechsler-Reya and Scott, 2001). Despite progress in research on the molecular aspects of malignant gliomas, the prognosis of these brain tumors continues to be dismal, with a median survival time of 12 months from the time of diagnosis. Neither continuous improvements in surgery and radiation techniques, nor in chemotherapy, have been able to change glioblastoma patients' life expectancy over decades.

This highly malignant tumor is thought to arise from astrocytes or astrocyte precursors, but the heterogeneity of GBM tumor morphology and behavior (as indicated by the term “multiforme”) makes conclusions about its origin extremely difficult (Wechsler-Reya and Scott, 2001). Recently, several experimental observations have led to formulate the hypothesis that this type of malignancy might arise from the transformation of adult neural stem cells, normally present in the brain just in the main areas of distribution of brain tumors, and able to trigger gliomagenesis in response to oncogenic mutations (Singh et al., 2003; Singh et al., 2004; Galli et al., 2004; Tunici et al., 2004; Yuan et al., 2004; Sanai et al., 2005).

Type
Chapter
Information
MicroRNAs
From Basic Science to Disease Biology
, pp. 350 - 362
Publisher: Cambridge University Press
Print publication year: 2007

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References

Bottoni, A., Piccin, D., Tagliati, F.et al. (2005). miR-15a and miR-16-1 down-regulation in pituitary adenomas. Journal of Cell Physiology, 204, 280–285.Google Scholar
Calin, G. A., Dumitru, C. D., Shimizu, M.et al. (2002). Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proceedings of the Natural Academy of Sciences USA, 99, 15 524–15 529.Google Scholar
Calin, G. A., Sevignani, C., Dumitru, C. D.et al. (2004a). Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proceedings of the Natural Academy of Sciences USA, 101, 2999–3004.Google Scholar
Calin, G. A., Liu, C. G., Sevignani, C.et al. (2004b). MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias. Proceedings of the Natural Academy of Sciences USA, 101, 11 755–11 760.Google Scholar
Chan, J. A., Krichevsky, A. M. and Kosik, K. S. (2005). MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Research, 65, 6029–6033.Google Scholar
Ciafrè, S. A., Galardi, S., Mangiola, A.et al. (2005). Extensive modulation of a set of microRNAs in primary glioblastoma. Biochemical and Biophysical Research Communications, 334, 1351–1358.Google Scholar
Cimmino, A., Calin, G. A., Fabbri, M.et al. (2005). miR-15 and miR-16 induce apoptosis by targeting BCL2. Proceedings of the Natural Academy of Sciences USA, 102, 13 944–13 949.Google Scholar
Dostie, J., Mourelatos, Z., Yang, M., Sharma, A. and Dreyfuss, G. (2003). Numerous microRNPs in neuronal cells containing novel microRNAs. RNA, 9, 180–186.Google Scholar
Esau, C., Kang, X., Peralta, E.et al. (2004). MicroRNA-143 regulates adipocyte differentiation. Journal of Biological Chemistry, 279, 52 361–52 365.Google Scholar
Galli, R., Binda, E., Orfanelli, U.et al. (2004). Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Research, 64, 7011–7021.Google Scholar
Gregory, R. I. and Shiekhattar, R. (2005). MicroRNA biogenesis and cancer. Cancer Research, 65, 3509–3512.Google Scholar
He, L., Thomson, J. M., Hemann, M. T.et al. (2005). A microRNA polycistron as a potential human oncogene. Nature, 435, 828–833.Google Scholar
Hulleman, E. and Helin, K. (2005). Molecular mechanisms in gliomagenesis. Advances in Cancer Research, 94, 1–27.Google Scholar
Iorio, M. V., Ferracin, M., Liu, C. G.et al. (2005). MicroRNA gene expression deregulation in human breast cancer. Cancer Research, 65, 7065–7070.Google Scholar
Johnson, S. M., Grosshans, H., Shingara, J.et al. (2005). RAS is regulated by the let-7 microRNA family. Cell, 120, 635–647.Google Scholar
Kim, V. N. (2005). MicroRNA biogenesis: coordinated cropping and dicing. Nature Reviews in Molecular and Cellular Biology, 6, 376–385.Google Scholar
Kleihues, P., Louis, D. N., Scheithauer, B. W.et al. (2002). The WHO classification of tumors of the nervous system. Journal of Neuropathology and Experimental Neurology, 61, 215–225; discussion 226–229.Google Scholar
Klein, M. E., Impey, S. and Goodman, R. H. (2005). Role reversal: the regulation of neuronal gene expression by microRNAs. Current Opinions in Neurobiology, 15, 507–513.Google Scholar
Kluiver, J., Poppema, S., Jong, D.et al. (2005). BIC and miR-155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas. Journal of Pathology, 207, 243–249.Google Scholar
Krichevsky, A. M., King, K. S., Donahue, C. P., Khrapko, K. and Kosik, K. S. (2003). A microRNA array reveals extensive regulation of microRNAs during brain development. RNA, 9, 1274–1281.Google Scholar
Liu, C. G., Calin, G. A., Meloon, B.et al. (2004). An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues. Proceedings of the Natural Academy of Sciences USA, 101, 9740–9744.Google Scholar
Metzler, M., Wilda, M., Busch, K., Viehmann, S. and Borkhardt, A. (2004). High expression of precursor microRNA-155/BIC RNA in children with Burkitt lymphoma. Genes Chromosomes and Cancer, 39, 167–169.Google Scholar
Michael, M. Z., O'Connor, S. M., Holst Pellekaan, N. G., Young, G. P. and James, R. J. (2003). Reduced accumulation of specific microRNAs in colorectal neoplasia. Molecular Cancer Research, 1, 882–891.Google Scholar
Mischel, P. S., Shai, R., Shi, T.et al. (2003). Identification of molecular subtypes of glioblastoma by gene expression profiling. Oncogene, 22, 2361–2373.Google Scholar
Miska, E. A., Alvarez-Saavedra, E., Townsend, M.et al. (2004). Microarray analysis of microRNA expression in the developing mammalian brain. Genome Biology, 5, R68.Google Scholar
Nigro, J. M., Misra, A., Zhang, L.et al. (2005). Integrated array-comparative genomic hybridization and expression array profiles identify clinically relevant molecular subtypes of glioblastoma. Cancer Research, 65, 1678–1686.Google Scholar
O'Donnell, K. A., Wentzel, E. A., Zeller, K. I., Dang, C. V. and Mendell, J. T. (2005). c-Myc-regulated microRNAs modulate E2F1 expression. Nature, 435, 839–843.Google Scholar
Pasquinelli, A. E., Hunter, S. and Bracht, J. (2005). MicroRNAs: a developing story. Current Opinions in Genetic Development, 15, 200–205.Google Scholar
Reifenberger, G. and Collins, V. P. (2004). Pathology and molecular genetics of astrocytic gliomas. Journal of Molecular Medicine, 82, 656–670.Google Scholar
Rogelj, B. and Giese, K. P. (2004). Expression and function of brain specific small RNAs. Reviews in Neurosciences, 15, 185–198.Google Scholar
Saito-Ohara, F., Imoto, I., Inoue, J.et al. (2003). PPM1D is a potential target for 17q gain in neuroblastoma. Cancer Research, 63, 1876–1883.Google Scholar
Sanai, N., Alvarez-Buylla, A. and Berger, M. S. (2005). Neural stem cells and the origin of gliomas. New England Journal of Medicine, 353, 811–822.Google Scholar
Sempere, L. F., Freemantle, S., Pitha-Rowe, I.et al. (2004). Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation. Genome Biology, 5, R13.Google Scholar
Singh, S. K., Clarke, I. D., Terasaki, M.et al. (2003). Identification of a cancer stem cell in human brain tumors. Cancer Research, 63, 5821–5828.Google Scholar
Singh, S. K., Clarke, I. D., Hide, T. and Dirks, P. B. (2004). Cancer stem cells in nervous system tumors. Oncogene, 23, 7267–7273.Google Scholar
Smirnova, L., Grafe, A., Seiler, A., et al. (2005). Regulation of miRNA expression during neural cell specification. European Journal of Neurosciences, 21, 1469–1477.Google Scholar
Tunici, P., Bissola, L., Lualdi, E.et al. (2004). Genetic alterations and in vivo tumorigenicity of neurospheres derived from an adult glioblastoma. Molecular Cancer, 3, 25.Google Scholar
Boom, J., Wolter, M., Kuick, R.et al. (2003). Characterization of gene expression profiles associated with glioma progression using oligonucleotide-based microarray analysis and real-time reverse transcription-polymerase chain reaction. American Journal of Pathology, 163, 1033–1043.Google Scholar
Wechsler-Reya, R. and Scott, M. P. (2001). The developmental biology of brain tumors. Annual Reviews of Neurosciences, 24, 385–428.Google Scholar
Wienholds, E. and Plasterk, R. H. (2005). MicroRNA function in animal development. Federation of the European Biochemical Sciences Letters, 579, 5911–5922.Google Scholar
Yuan, X., Curtin, J., Xiong, Y.et al. (2004). Isolation of cancer stem cells from adult glioblastoma multiforme. Oncogene, 23, 9392–400.Google Scholar
Zhu, Y. and Parada, L. F. (2002). The molecular and genetic basis of neurological tumours. Nature Reviews Cancer, 2, 616–626.Google Scholar

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