This chapter charts several key points of contact between Nietzsche and the hermeneutical tradition. It begins by arguing that the familiar claim that Nietzsche offers a hermeneutics of suspicion is potentially misleading. Seeking a more accurate representation of Nietzsche’s views, the chapter argues that Nietzsche’s interpretive stance has several key features: he rejects immediate givens, endorses holism and perspectivism, and sees conscious experience as structured by concepts and language. Methodologically, Nietzsche inaugurates a genealogical approach to studying objects of philosophical concern, and offers a series of thoughts and arguments on perspectives and the ways in which they might be assessed. After explaining these points, the chapter reviews the way in which Nietzsche takes religious, moral, and philosophical systems as aspiring to provide an interpretation of existence that renders it meaningful. The closing section briefly discusses the Nietzschean approach to interpretation that is adopted by Foucault.