Skip to main content Accessibility help
×
Hostname: page-component-848d4c4894-m9kch Total loading time: 0 Render date: 2024-05-05T01:00:38.527Z Has data issue: false hasContentIssue false

Chapter 28 - The Luteal Phase Support in In Vitro Fertilization

from Section 6 - Procedures before, during, and after Ovarian Stimulation

Published online by Cambridge University Press:  14 April 2022

Mohamed Aboulghar
Affiliation:
University of Cairo IVF Centre
Botros Rizk
Affiliation:
University of South Alabama
Get access

Summary

The luteal phase is defined as the period between ovulation and either the establishment of a pregnancy or the onset of menses two weeks later [1]. Following ovulation, the luteal phase of a natural cycle is characterized by the formation of a corpus luteum, which secretes steroid hormones, including progesterone and estradiol (E2).

Type
Chapter
Information
Ovarian Stimulation , pp. 290 - 301
Publisher: Cambridge University Press
Print publication year: 2022

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Fatemi, HM, Popovic-Todorovic, B, Papanikolaou, E, Donoso, P, Devroey, P. An update of luteal phase support in stimulated IVF cycles Hum Reprod Update 2007;13(6):581590.Google Scholar
Penzias, AS. Luteal phase support. Fertil Steril 2002;77:318323.Google Scholar
Scott, R, Navot, D, Liu, HC, et al. A human in vivo model for the luteoplacental shift. Fertil Steril 1991;56:481484.Google Scholar
Ubaldi, F, Bourgain, C, Tournaye, H, et al. Endometrial evaluation by aspiration biopsy on the day of oocyte retrieval in the embryo transfer cycles in patients with serum progesterone rise during the follicular phase. Fertil Steril 1997;67:521526.CrossRefGoogle ScholarPubMed
Macklon, NS, Fauser, BC. Impact of ovarian hyperstimulation on the luteal phase. J Reprod Fertil 2000;55(Suppl):101108.Google ScholarPubMed
Kolibianakis, EM, Devroey, P. The luteal phase after ovarian stimulation. Reprod Biomed Online 2002;5(Suppl 1):2635.Google Scholar
van der Linden, M, Buckingham, K, Farquhar, C, Kremer, JA, Metwally, M. Luteal phase support for assisted reproduction cycles. Cochrane Database Syst Rev 2015;7:CD009154.Google Scholar
Rosenberg, SM, Luciano, AA, Riddick, DH. The luteal phase defect: the relative frequency of, and encouraging response to, treatment with vaginal progesterone. Fertil Steril 1980;34:1720.Google Scholar
Edwards, RG, Steptoe, PC, Purdy, JM. Establishing full-term human pregnancies using cleaving embryos grown in vitro. Br J Obstet Gynaecol 1980;87:737756.CrossRefGoogle ScholarPubMed
Smitz, J, Devroey, P, Faguer, B, et al. A randomized prospective study comparing supplementation of the luteal phase and early pregnancy by natural progesterone administered by intramuscular or vaginal route. Rev Fr Gynecol Obstet 1992;87:507516.Google Scholar
Smitz, J, Erard, P, Camus, M, et al. Pituitary gonadotrophin secretory capacity during the luteal phase in superovulation using GnRH-agonists and HMG in a desensitization or flare-up protocol. Hum Reprod 1992;7: 12251229.Google Scholar
Kerin, JF, Broom, TJ, Ralph, MM, et al. Human luteal phase function following oocyte aspiration from the immediately preovular graafian follicle of spontaneous ovular cycles. Br J Obstet Gynaecol 1981;88:10211028.Google Scholar
Miyake, A, Aono, T, Kinugasa, T, Tanizawa, O, Kurachi, K. Suppression of serum levels of luteinizing hormone by short- and long-loop negative feedback in ovariectomized women. J Endocrinol 1979;80:353356.Google Scholar
Tavaniotou, A, Devroey, P. Effect of human chorionic gonadotropin on luteal luteinizing hormone concentrations in natural cycles. Fertil Steril 2003; 80:654655.Google Scholar
Albano, C, Smitz, J, Camus, M, et al. Hormonal profile during the follicular phase in cycles stimulated with a combination of human menopausal gonadotrophin and gonadotrophin-releasing hormone antagonist (cetrorelix). Hum Reprod 1996;11:21142118.CrossRefGoogle ScholarPubMed
Albano, C, Grimbizis, G, Smitz, J, et al. The luteal phase of nonsupplemented cycles after ovarian superovulation with human menopausal gonadotropin and the gonadotropin-releasing hormone antagonist cetrorelix. Fertil Steril 1998;70:357359.Google Scholar
Beckers, NG, Macklon, NS, Eijkemans, MJ, et al. Nonsupplemented luteal phase characteristics after the administration of recombinant human chorionic gonadotropin, recombinant luteinizing hormone, or gonadotropin-releasing hormone (GnRH) agonist to induce final oocyte maturation in in vitro fertilization patients after ovarian stimulation with recombinant follicle-stimulating hormone and GnRH antagonist cotreatment. J Clin Endocrinol Metab 2003;88:41864192.Google Scholar
Tarlatzis, BC, Fauser, BC, Kolibianakis, EM, et al. GnRH antagonists in ovarian stimulation for IVF. Hum Reprod Update 2006;12:333340.CrossRefGoogle ScholarPubMed
Fauser, BC, Devroey, P. Reproductive biology and IVF: ovarian stimulation and luteal phase consequences. Trends Endocrinol Metab 2003;14(5):236242.CrossRefGoogle ScholarPubMed
Jones, GS. Luteal phase defect: a review of pathophysiology. Curr Opin Obstet Gynecol 1991;3:641648.Google Scholar
Casper, RF, Yen, SS. Induction of luteolysis in the human with a long-acting analog of luteinizing hormone-releasing factor. Science 1979;205:408410.Google Scholar
Duffy, DM, Stewart, DR, Stouffer, RL. Titrating luteinizing hormone replacement to sustain the structure and function of the corpus luteum after gonadotropin-releasing hormone antagonist treatment in rhesus monkeys. J Clin Endocrinol Metab 1999;84:342349.Google Scholar
Practice Committee of the American Society for Reproductive Medicine. Progesterone supplementation during the luteal phase and in early pregnancy in the treatment of infertility: an educational bulletin. Fertil Steril 2008;89:789792.Google Scholar
Csapo, AI, Pulkkinen, MO, Ruttner, B, Sauvage, JP, Wiest, WG. The significance of the human corpus luteum in pregnancy maintenance. I. Preliminary studies. Am J Obstet Gynecol 1972;112:10611067.Google Scholar
Csapo, AI, Pulkkinen, MO, Wiest, WG. Effects of lutectomy and progesterone replacement therapy in early pregnant patients. Am J Obstet Gynecol 1973;115:759765.Google Scholar
Bourgain, C, Devroey, P, Van Waesberghe, L, Smitz, J, Van Steirteghem, AC. Effects of natural progesterone on the morphology of the endometrium in patients with primary ovarian failure. Hum Reprod 1990;5:537543.Google Scholar
Martin, J, Dominguez, F, Avila, S, et al. Human endometrial receptivity: gene regulation. J Reprod Immunol 2002;55:131139.Google Scholar
Paulson, RJ, Sauer, MV, Lobo, RA. Embryo implantation after human in vitro fertilization: importance of endometrial receptivity. Fertil Steril 1990;53:870874.Google Scholar
Bulletti, C, de Ziegler, D. Uterine contractility and embryo implantation. Curr Opin Obstet Gynecol 2005;17:265276.CrossRefGoogle ScholarPubMed
Fanchin, R, Righini, C, Olivennes, F, et al. Uterine contractions at the time of embryo transfer alter pregnancy rates after in-vitro fertilization. Hum Reprod 1998;13:19681974.Google Scholar
Simon, JA, Robinson, DE, Andrews, MC, et al. The absorption of oral micronized progesterone: the effect of food, dose proportionality, and comparison with intramuscular progesterone. Fertil Steril 1993;60:2633.CrossRefGoogle ScholarPubMed
Tavaniotou, A, Smitz, J, Bourgain, C, Devroey, P. Comparison between different routes of progesterone administration as luteal phase support in infertility treatments. Hum Reprod Update 2000;6:139148.CrossRefGoogle ScholarPubMed
Sator, M, Radicioni, M, Cometti, B, et al. Pharmacokinetics and safety profile of a novel progesterone aqueous formulation administered by the s.c. route. Gynecol Endocrinol 2013;29:205208.Google Scholar
Hubayter, Z, Muasher, S. Luteal supplementation in in vitro fertilization: more questions than answers. Fertil Steril 2008;89(4):749758.Google Scholar
de Ziegler, D, Seidler, L, Scharer, E, Bouchard, P. Non-oral administration of progesterone: experiences and possibilities of the transvaginal route. Schweiz Rundsch Med Prax 1995;84:127133.Google Scholar
Whitehead, MI, Townsend, PT, Gill, DK, Collins, WP, Campbell, S. Absorption and metabolism of oral progesterone. Br Med J 1980;280:825827.CrossRefGoogle ScholarPubMed
Chakravarty, BN, Shirazee, HH, Dam, P, et al. Oral dydrogesterone versus intravaginal micronised progesterone as luteal phase support in assisted reproductive technology (ART) cycles: results of a randomised study. J Steroid Biochem Mol Biol 2005;97:416420.CrossRefGoogle ScholarPubMed
Tournaye, H, Sukhikh, G, Kuhler, E, Griesinger, G. A phase III randomized controlled trial comparing the efficacy, safety and tolerability of oral dydrogesterone versus micronized vaginal progesterone for luteal support in in vitro fertilization. Hum Reprod 2017;32(5):10191027.Google Scholar
Levine, H. Luteal support in IVF using the novel vaginal progesterone gel Crinone 8%: results of an open-label trial in 1184 women from 16 US centers. Fertil Steril 2000;74:836837.Google Scholar
Cicinelli, E, Schonauer, LM, Galantino, P, et al. Mechanisms of uterine specificity of vaginal progesterone. Hum Reprod 2000;15(Suppl 1):159165.Google Scholar
Vaisbuch, E, Leong, M, Shoham, Z. Progesterone support in IVF: is evidence-based medicine translated to clinical practice? A worldwide web-based survey. Reprod Biomed Online 2012;25:139145.CrossRefGoogle ScholarPubMed
Simunic, V, Tomic, V, Tomic, J, Nizic, D. Comparative study of the efficacy and tolerability of two vaginal progesterone formulations, Crinone 8% gel and Utrogestan capsules, used for luteal phase support. Fertil Steril 2007;87:8387.Google Scholar
Costabile, L, Gerli, S, Manna, C, et al. A prospective randomized study comparing intramuscular progesterone and 17alpha-hydroxyprogesterone caproate in patients undergoing in vitro fertilization-embryo transfer cycles. Fertil Steril 2001;76:394396.Google Scholar
Pritts, EA, Atwood, AK. Luteal phase support in infertility treatment: a meta-analysis of the randomized trials. Hum Reprod 2002;17:22872299.Google Scholar
Lightman, A, Kol, S, Itskovitz-Eldor, J. A prospective randomized study comparing intramuscular with intravaginal natural progesterone in programmed thaw cycles. Hum Reprod 1999;14:25962599.Google Scholar
Propst, AM, Hill, JA, Ginsburg, ES, et al. A randomized study comparing Crinone 8% and intramuscular progesterone supplementation in in vitro fertilization-embryo transfer cycles. Fertil Steril 2001;76:11441149.Google Scholar
Bouckaert, Y, Robert, F, Englert, Y, et al. Acute eosinophilic pneumonia associated with intramuscular administration of progesterone as luteal phase support after IVF: case report. Hum Reprod 2004;19:18061810.Google Scholar
Veysman, B, Vlahos, I, Oshva, L. Pneumonitis and eosinophilia after in vitro fertilization treatment. Ann Emerg Med 2006;47:472475.Google Scholar
Baker, V, Jones, C, Doody, K, et al. A randomized controlled trial comparing the efficacy and safety of aqueous subcutaneous progesterone with vaginal progesterone for luteal phase support of in vitro fertilization. Hum Reprod 2014;29(10):22102220.Google Scholar
Doblinger, J, Cometti, B, Trevisan, S, Griesinger, G. Subcutaneous progesterone is effective and safe for luteal phase support in IVF: an individual patient data meta-analysis of the phase III trials. PLoS One 2016;11(3):e0151388.Google Scholar
Johnson, MR, Abbas, AA, Irvine, R, et al. Regulation of corpus luteum function. Hum Reprod 1994;9:4148.Google Scholar
Maslar, IA, Ansbacher, R. Effect of short-duration progesterone treatment on decidual prolactin production by cultures of proliferative human endometrium. Fertil Steril 1988;50:250254.Google Scholar
Sharara, FI, McClamrock, HD. Ratio of oestradiol concentration on the day of human chorionic gonadotrophin administration to mid-luteal oestradiol concentration is predictive of in-vitro fertilization outcome. Hum Reprod 1999;14(11):27772782.Google Scholar
Ludwig, M, Diedrich, K. Evaluation of an optimal luteal phase support protocol in IVF. Acta Obstet Gynecol Scand 2001;80:452466.CrossRefGoogle ScholarPubMed
Fatemi, HM, Camus, M, Kolibianakis, EM, et al. The luteal phase of recombinant follicle-stimulating hormone/gonadotropin-releasing hormone antagonist in vitro fertilization cycles during supplementation with progesterone or progesterone and estradiol. Fertil Steril 2006;87:504508.Google Scholar
Fatemi, HM, Kolibianakis, EM, Camus, M, et al. Addition of estradiol to progesterone for luteal supplementation in patients stimulated with GnRH antagonist/rFSH for IVF: a randomized controlled trial. Hum Reprod 2006;21:26282632.Google Scholar
Kolibianakis, EM, Venetis, CA, Papanikolaou, EG, et al. Estrogen addition to progesterone for luteal phase support in cycles stimulated with GnRH analogues and gonadotrophins for IVF: a systematic review and meta-analysis. Hum Reprod 2008;23(6):13461354.CrossRefGoogle ScholarPubMed
Lawrenz, B, Samir, S, Garrido, N, et al. Luteal coasting and individualization of human chorionic gonadotropin dose after gonadotropin-releasing hormone agonist triggering for final oocyte maturation: a retrospective proof-of-concept study. Front Endocrinol (Lausanne) 2018;9:33.CrossRefGoogle ScholarPubMed
Itskovitz, J, Boldes, R, Levron, J, et al. Induction of preovulatory luteinizing hormone surge and prevention of ovarian hyperstimulation syndrome by gonadotropin-releasing hormone agonist. Fertil Steril 1991;56(2):213220.CrossRefGoogle ScholarPubMed
Zelinski-Wooten, MB, Lanzendorf, SE, Wolf, DP, Chandrasekher, YA, Stouffer, RL. Titrating luteinizing hormone surge requirements for ovulatory changes in primate follicles. I. Oocyte maturation and corpus luteum function. J Clin Endocrinol Metab 1991;73(3):577583.Google Scholar
Engmann, L, Benadiva, C, Humaidan, P. GnRH agonist trigger for the induction of oocyte maturation in GnRH antagonist IVF cycles: a SWOT analysis. Reprod Biomed Online 2016;32(3):274285.CrossRefGoogle ScholarPubMed
Lawrenz, B, Humaidan, P, Kol, S, Fatemi, HM. GnRHa trigger and luteal coasting: a new approach for the ovarian hyperstimulation syndrome high-risk patient? Reprod Biomed Online 2018;36(1):7577.Google Scholar
Fatemi, HM, Popovic-Todorovic, B, Humaidan, P, et al. Severe ovarian hyperstimulation syndrome after gonadotrophin-releasing hormone (GnRH) agonist trigger and ‘freeze-all’ approach in GnRH antagonist protocol. Fertil Steril 2014;101:10081011.Google Scholar
Lawrenz, B, Garrido, N, Samir, S, et al. Individual luteolysis pattern after GnRH-agonist trigger for final oocyte maturation. PLoS One 2017;12:e0176600.Google Scholar
Hutchison, JS, Zeleznik, AJ. The corpus luteum of the primate menstrual cycle is capable of recovering from a transient withdrawal of pituitary gonadotrophin support. Endocrinology 1985;117:10431049.Google Scholar
Dubourdieu, S, Charbonnel, B, Massai, MR, et al. Suppression of corpus luteum function by the gonadotrophin-releasing hormone antagonist Nal-Glu: effect of the dose and timing of human chorionic gonadotrophin administration. Fertil Steril 1991;56:440512.Google Scholar
Kol, S, Breyzman, T, Segal, L, Humaidan, P.Luteal coasting’ after GnRH agonist trigger–individualized, HCG-based, progesterone-free luteal support in ‘high responders’: a case series. Reprod Biomed Online 2015;31:747751.Google Scholar
Pirard, C, Donnez, J, Loumaye, E. GnRH agonist as novel luteal support: results of a randomized, parallel group, feasibility study using intranasal administration of buserelin. Hum Reprod 2005;20:17981804.Google Scholar
Bar-Hava, I, Mizrachi, Y, Karfunkel-Doron, D, et al. Intranasal gonadotropin-releasing hormone agonist (GnRHa) for luteal-phase support following GnRHa triggering, a novel approach to avoid ovarian hyperstimulation syndrome in high responders. Fertil Steril 2016;106:330333.Google Scholar
Buettner, GR. The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. Arch Biochem Biophys 1993;300:535543.Google Scholar
Millar, J. Vitamin C–the primate fertility factor? Med Hypotheses 1992;38:292295.Google Scholar
Margolin, Y, Aten, RF, Behrman, HR. Antigonadotropic and antisteroidogenic actions of peroxide in rat granulosa cells. Endocrinology 1990;127:245250.Google Scholar
Polak, G, Koziol-Montewka, M, Gogacz, M, Kotarski, J. Total antioxidant status of peritoneal fluid in infertile women. Eur J Obstet Gynecol Reprod Biol 2001;94:261263.Google Scholar
Griesinger, G, Franke, K, Kinast, C, et al. Ascorbic acid supplement during luteal phase in IVF. J Assist Reprod Genet 2002;19:164168.CrossRefGoogle ScholarPubMed
Lee, KA, Koo, JJ, Yoon, TK, et al. Immunosuppression by corticosteroid has no effect on the pregnancy rate in routine in-vitro fertilization/embryo transfer patients. Hum Reprod 1994;9:18321835.Google Scholar
Ubaldi, F, Rienzi, L, Ferrero, S, et al. Low dose prednisolone administration in routine ICSI patients does not improve pregnancy and implantation rates. Hum Reprod 2002;17:15441547.Google Scholar
Moffitt, D, Queenan, JT Jr., Veeck, LL, et al. Low-dose glucocorticoids after in vitro fertilization and embryo transfer have no significant effect on pregnancy rate. Fertil Steril 1995;63:571577.CrossRefGoogle ScholarPubMed
Dan, S, Wei, W, Yichao, S, et al. Effect of prednisolone administration on patients with unexplained recurrent miscarriage and in routine intracytoplasmic sperm injection: a meta-analysis. Am J Reprod Immunol 2015;74(1):8997.Google Scholar
Vane, JR, Flower, RJ, Botting, RM. History of aspirin and its mechanism of action. Stroke 1990;21:IV12–IV23.Google Scholar
Okuda, K, Miyamoto, Y, Skarzynski, DJ. Regulation of endometrial prostaglandin F(2alpha) synthesis during luteolysis and early pregnancy in cattle. Domest Anim Endocrinol 2002;23:255264.Google Scholar
Wada, I, Hsu, CC, Williams, G, Macnamee, MC, Brinsden, PR. The benefits of low-dose aspirin therapy in women with impaired uterine perfusion during assisted conception. Hum Reprod 1994;9:19541957.CrossRefGoogle ScholarPubMed
Weckstein, LN, Jacobson, A, Galen, D, Hampton, K, Hammel, J. Low-dose aspirin for oocyte donation recipients with a thin endometrium: prospective, randomized study. Fertil Steril 1997;68:927930.Google Scholar
Rubinstein, M, Marazzi, A, Polak, DF. Low-dose aspirin treatment improves ovarian responsiveness, uterine and ovarian blood flow velocity, implantation, and pregnancy rates in patients undergoing in vitro fertilization: a prospective, randomized, double-blind placebo-controlled assay. Fertil Steril 1999;71:825829.Google Scholar
Urman, B, Mercan, R, Alatas, C, et al. Low-dose aspirin does not increase implantation rates in patients undergoing intracytoplasmic sperm injection: a prospective randomized study. J Assist Reprod Genet 2000;17:586590.Google Scholar
Hurst, BS, Bhojwani, JT, Marshburn, PB, et al. Low-dose aspirin does not improve ovarian stimulation, endometrial response, or pregnancy rates for in vitro fertilization. J Exp Clin Assist Reprod 2005;2:8.Google Scholar
Geva, E, Amit, A, Lerner-Geva, L, et al. Prednisone and aspirin improve pregnancy rate in patients with reproductive failure and autoimmune antibodies: a prospective study. Am J Reprod Immunol 2000;43:3640.Google Scholar
Whelan, JG III, Vlahos, NF. The ovarian hyperstimulation syndrome. Fertil Steril 2000;73:883896.Google Scholar
Hutchinson-Williams, KA, DeCherney, AH, Lavy, G, et al. Luteal rescue in in vitro fertilization-embryo transfer. Fertil Steril 1990;53:495501.CrossRefGoogle ScholarPubMed
Anthony, FW, Smith, EM, Gadd, SC, et al. Placental protein 14 secretion during in vitro fertilization cycles with and without human chorionic gonadotropin for luteal support. Fertil Steril 1993;59:187191.Google Scholar
Honda, T, Fujiwara, H, Yamada, S, et al. Integrin alpha5 is expressed on human luteinizing granulosa cells during corpus luteum formation, and its expression is enhanced by human chorionic gonadotrophin in vitro. Mol Hum Reprod 1997;3:979984.Google Scholar
Ghosh, D, Stewart, DR, Nayak, NR, et al. Serum concentrations of oestradiol-17beta, progesterone, relaxin and chorionic gonadotrophin during blastocyst implantation in natural pregnancy cycle and in embryo transfer cycle in the rhesus monkey. Hum Reprod 1997;12:914920.Google Scholar
Herman, A, Ron-El, R, Golan, A, et al. Pregnancy rate and ovarian hyperstimulation after luteal human chorionic gonadotropin in in vitro fertilization stimulated with gonadotropin-releasing hormone analog and menotropins. Fertil Steril 1990;53:9296.CrossRefGoogle ScholarPubMed
Mochtar, MH, Hogerzeil, HV, Mol, BW. Progesterone alone versus progesterone combined with HCG as luteal support in GnRHa/HMG induced IVF cycles: a randomized clinical trial. Hum Reprod 1996;11:16021605.CrossRefGoogle ScholarPubMed
Pirard, C, Donnez, J, Loumaye, E. GnRH agonist as novel luteal support: results of a randomized, parallel group, feasibility study using intranasal administration of buserelin. Hum Reprod (2005) 20:17981804CrossRefGoogle ScholarPubMed
Tesarik, J, Hazout, A, Mendoza-Tesarik, R, Mendoza, N, Mendoza, C. Beneficial effect of luteal-phase GnRH agonist administration on embryo implantation after ICSI in both GnRH agonist- and antagonist-treated ovarian stimulation cycles. Hum Reprod 2006;21:25722579.Google Scholar
Pirard, C, Donnez, J, Loumaye, E. GnRH agonist as luteal phase support in assisted reproduction technique cycles: results of a pilot study. Hum Reprod 2006;21(7):18941900.Google Scholar
Tesarik, J, Hazout, A, Mendoza, C. Enhancement of embryo developmental potential by a single administration of GnRH agonist at the time of implantation. Hum Reprod 2004;19:11761180.Google Scholar
Kyrou, D, Kolibianakis, EM, Fatemi, HM, et al. Increased live birth rates with GnRH agonist addition for luteal support in ICSI/IVF cycles: a systematic review and meta‐analysis. Hum Reprod Update 2011;17:734740.CrossRefGoogle ScholarPubMed
Martins, WP, Ferriani, RA, Navarro, PA, Nastri, CO. GnRH agonist during luteal phase in women undergoing assisted reproductive techniques: systematic review and meta-analysis of randomized controlled trials. Ultrasound Obstet Gynecol 2016;47(2):144151.Google Scholar
Connell, MT, Szatkowski, JM, Terry, N, et al. Timing luteal support in assisted reproductive technology: a systematic review. Fertil Steril 2015;103:939946.Google Scholar
Proctor, A, Hurst, BS, Marshburn, PB, Matthews, ML. Effect of progesterone supplementation in early pregnancy on the pregnancy outcome after in vitro fertilization. Fertil Steril 2006;85:15501552.Google Scholar
Liu, XR, Mu, HQ, Shi, Q, Xiao, XQ, Qi, HB. The optimal duration of progesterone supplementation in pregnant women after IVF/ICSI: a meta-analysis. Reprod Biol Endocrinol 2012;10:107.Google Scholar
Pan, SP, Chao, KH, Huang, CC, et al. Early stop of progesterone supplementation after confirmation of pregnancy in IVF/ICSI fresh embryo transfer cycles of poor responders does not affect pregnancy outcome. PLoS One 2018;13(8):e0201824.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×