Book contents
- 50 Big Debates in Gynecologic Oncology
- 50 Big Debates in Gynecologic Oncology
- Copyright page
- Contents
- Contributors
- Section I Perioperative Management
- Section II Screening, Prevention, and Early Diagnosis
- Section III Ovarian Cancer
- Section IV Endometrial Cancer
- Section V Cervical Cancer
- Section VI Vaginal and Vulvar Cancer
- Debate 48A Should the Subsequent Management of Patients with Vulvar Cancer and a Positive Sentinel Lymph Node be Complete Groin Lymph Node Dissection or Radiation Therapy?
- Debate 48B Should the Subsequent Management of Patients with Vulvar Cancer and a Positive Sentinel Lymph Node be Complete Groin Lymph Node Dissection or Radiation Therapy?
- Debate 49A What is the Best Treatment for Stage I Vulvar Squamous Cell Carcinoma with either a Close or Positive Surgical Margin?
- Debate 49B What is the Best Treatment for Stage I Vulvar Squamous Cell Carcinoma with either a Close or Positive Surgical Margin?
- Debate 50A Should Adjuvant Radiation be Given to Women with Single Node Positive Vulvar Cancer?
- Debate 50B Should Adjuvant Radiation Therapy be Given to Patients with Single Node Positive Vulvar Cancer?
- Debate 51A Is Pelvic Exenteration an Option for a Pelvic Recurrence of a Vulvar/Vaginal Melanoma after Previous Radiation Therapy?
- Debate 51B Is Pelvic Exenteration an Option for a Pelvic Recurrence of a Vulvar/Vaginal Melanoma after Previous Radiation Therapy?
- Index
- References
Debate 49B - What is the Best Treatment for Stage I Vulvar Squamous Cell Carcinoma with either a Close or Positive Surgical Margin?
Adjuvant Radiation
from Section VI - Vaginal and Vulvar Cancer
Published online by Cambridge University Press: 20 July 2023
Book contents
- 50 Big Debates in Gynecologic Oncology
- 50 Big Debates in Gynecologic Oncology
- Copyright page
- Contents
- Contributors
- Section I Perioperative Management
- Section II Screening, Prevention, and Early Diagnosis
- Section III Ovarian Cancer
- Section IV Endometrial Cancer
- Section V Cervical Cancer
- Section VI Vaginal and Vulvar Cancer
- Debate 48A Should the Subsequent Management of Patients with Vulvar Cancer and a Positive Sentinel Lymph Node be Complete Groin Lymph Node Dissection or Radiation Therapy?
- Debate 48B Should the Subsequent Management of Patients with Vulvar Cancer and a Positive Sentinel Lymph Node be Complete Groin Lymph Node Dissection or Radiation Therapy?
- Debate 49A What is the Best Treatment for Stage I Vulvar Squamous Cell Carcinoma with either a Close or Positive Surgical Margin?
- Debate 49B What is the Best Treatment for Stage I Vulvar Squamous Cell Carcinoma with either a Close or Positive Surgical Margin?
- Debate 50A Should Adjuvant Radiation be Given to Women with Single Node Positive Vulvar Cancer?
- Debate 50B Should Adjuvant Radiation Therapy be Given to Patients with Single Node Positive Vulvar Cancer?
- Debate 51A Is Pelvic Exenteration an Option for a Pelvic Recurrence of a Vulvar/Vaginal Melanoma after Previous Radiation Therapy?
- Debate 51B Is Pelvic Exenteration an Option for a Pelvic Recurrence of a Vulvar/Vaginal Melanoma after Previous Radiation Therapy?
- Index
- References
Summary
Vulvar cancer is a rare and poorly studied disease. Mainstay of treatment is surgical resection, and it is common for margins to be close (≤8 mm) or positive. Margin status is one of the most important predictors for local recurrence, and local recurrence is tightly associated with poor overall survival. Options for management of a close/positive margin are re-excision or adjuvant radiation. Radiation has been studied for this indication for several decades, and can substantially reduce risk of recurrence in women with a close/positive margin after surgical resection. With excellent efficacy and acceptable side effect profile, radiation therapy is the treatment of choice for women with vulvar cancer at high risk of local recurrence.
- Type
- Chapter
- Information
- 50 Big Debates in Gynecologic Oncology , pp. 300 - 301Publisher: Cambridge University PressPrint publication year: 2023
References
SEER Database: Vulvar Cancer. Available from: https://seer.cancer.gov/statfacts/html/vulva.html [last accessed November 9, 2022].Google Scholar
Heaps, JM, et al. Surgical pathologic variables predictive of local recurrence in squamous cell carcinoma of the vulva. Gynecol Oncol 1990;38 (3):309.CrossRefGoogle ScholarPubMed
Ignatov, T, et al. Adjuvant radiotherapy for vulvar cancer with close or positive surgical margins. J Cancer Res Clin Oncol 2016;142:489–495.CrossRefGoogle ScholarPubMed
Alimena, S, et al. Patient reported outcome measures among patients with vulvar cancer at various stages of treatment, recurrence and survivorship. Gynecol Oncol 2021;160:252–259.Google ScholarPubMed
Grootenhuis, NC, et al. Margin status revisited in vulvar squamous cell carcinoma. Gynecol Oncol 2019;154(2):266–275.CrossRefGoogle Scholar