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Debate 8B - Should Stage IC Mucinous Ovarian Carcinoma be Managed by Observation or Adjuvant Chemotherapy?

Adjuvant Chemotherapy

from Section III - Ovarian Cancer

Published online by Cambridge University Press:  20 July 2023

Dennis S. Chi
Affiliation:
Memorial Sloan-Kettering Cancer Center, New York
Nisha Lakhi
Affiliation:
Richmond University Medical Center, Staten Island
Nicoletta Colombo
Affiliation:
University of Milan-Bicocca
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Summary

Mucinous ovarian carcinomas (MOCs) are a rare subtype of epithelial ovarian cancer accounting for less than 10% of all epithelial ovarian cancers. Improvements in diagnosis have suggested that the incidence has been overestimated and the true incidence is less than 5% [1]. Adjuvant chemotherapy studies have included mucinous tumors and other less common types of epithelial ovarian cancers together with high-grade serous tumors, the most common subtype.

Sixty-five to eighty percent of mucinous ovarian cancers are diagnosed at an early stage and have an excellent prognosis compared to early-stage serous cancers. The standard treatment approach for stage I MOC is surgery and based upon the surgical and pathological staging, further adjuvant treatment may be needed.

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Publisher: Cambridge University Press
Print publication year: 2023

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References

Crane, EK, et al. Early stage mucinous ovarian cancer: a review. Gynecol Oncol 2018;149(3):598604.CrossRefGoogle ScholarPubMed
Trimbos, JB, et al. International Collaborative Ovarian Neoplasm trial 1 and Adjuvant ChemoTherapy In Ovarian Neoplasm trial: two parallel randomized phase III trials of adjuvant chemotherapy in patients with early-stage ovarian carcinoma. J Natl Cancer Inst 2003;95(2):105112.CrossRefGoogle ScholarPubMed
Richardson, MT, et al. Long-term survival outcomes of stage I mucinous ovarian cancer – A clinical calculator predictive of chemotherapy benefit. Gynecol Oncol 2020;159(1):118128.CrossRefGoogle Scholar
Nasioudis, D, et al. Adjuvant chemotherapy is not associated with a survival benefit for patients with early stage mucinous ovarian carcinoma. Gynecol Oncol 2019;154(2):302307.CrossRefGoogle Scholar
Matsuo, K, et al. Effectiveness of postoperative chemotherapy for stage IC mucinous ovarian cancer. Gynecol Oncol 2019;154(3):505515.CrossRefGoogle ScholarPubMed

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