Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-848d4c4894-wg55d Total loading time: 0 Render date: 2024-05-01T01:36:12.078Z Has data issue: false hasContentIssue false

Chapter 18 - Review of Treatment for Late-Life Depression

from Section 3 - Approaches to Management

Published online by Cambridge University Press:  12 September 2020

By
Katherine Hay ,
Will Stageman  and
Charlotte L Allan
Edited by
Julian C. Hughes  and
Philippa Lilford
Julian C. Hughes
Affiliation:
University of Bristol
Philippa Lilford
Affiliation:
Severn Deanery, University of Bristol
Get access

Summary

In 2018, Public Health England reported that one in five older people living in the community and two in five older people living in care homes are affected by depression. These symptoms are associated with reduced quality of life and high morbidity, and also with increased mortality through suicide and self-neglect. A 2014 study showed that major depression was associated with a 43% increase in the risk of non-suicide-related mortality in adults over the age of 50. Depression across all age groups has a detrimental impact on recovery from surgery and in older people, increases the risk of coronary heart disease and stroke., There is a gathering body of evidence that depression is a risk factor for dementia and, that in people with mild cognitive impairment, the presence of depression may increase the risk of progression to dementia.

Type
Chapter
Information
Clinical Topics in Old Age Psychiatry , pp. 243 - 253
Publisher: Cambridge University Press
Print publication year: 2020

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Better Mental Health for All: A Public Health Approach to Mental Health Improvement (2018) London: Faculty of Public Health and Mental Health Foundation.Google Scholar
Sivertsen, H, Bjorklof, GH, Engedal, K et al. Depression and quality of life in older persons: a review. Dement Geriatr Cogn Disord 2015; 40: 311–339.CrossRefGoogle ScholarPubMed
Djernes, JK, Gulmann, NC, Foldager, L et al. 13 Year follow up of morbidity, mortality and use of health services among elderly depressed patients and general elderly populations. Aust N Z J Psychiatry 2011; 45[8]: 654–662.Google Scholar
Saint Onge, JM, Krueger, PM, Rogers, RG. The relationship between major depression and nonsuicide mortality for U.S. adults: the importance of health behaviours. J. Gerontol B Psychol Soc Sci 2014; 69[4]: 622–632.CrossRefGoogle Scholar
Ghoneim, MM, O’Hara, MW. Depression and postoperative complications: an overview. BMC Surg 2018; 18: 5.Google Scholar
Pequignot, R, Dufouil, C, Prugger, C et al. High level of depressive symptoms at repeated study visits and risk of coronary heart disease and stroke over 10 years in older adults: the three-city study. J Am Geriatr Soc. 2018; 64[1]: 118–125.Google Scholar
Gallagher, D, Kiss, A, Lanctot, K et al. Depression and risk of Alzheimer dementia: a longitudinal analysis to determine predictors of increased risk among older adults with depression. Am J Geriatr Psychiatry 2018; 26[8]: 819–827.Google Scholar
American Psychiatric Association. The Diagnostic and Statistical Manual of Mental Disorders (5th edition). 2013.CrossRefGoogle Scholar
World Health Organization. The International Statistical Classification of Diseases and Related Health Problems (11th Revision). 2018.Google Scholar
Hegeman, JM, Kok, RM, van der Mast, RC et al. Phenomenology of depression in older compared with younger adults: meta-analysis. Br J Psychiatry 2012; 200[4]: 275–281.CrossRefGoogle ScholarPubMed
Brown, MN, Lapane, KL, Luisi, AF. The management of depression in older nursing home residents. J Am Geriatr Soc 2002; 50[1]: 69–76.Google Scholar
Cipriani, A, Furukawa, TA, Salanti, G et al. Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis. Lancet 2009; 373[9665]: 746–758.Google Scholar
Nelson, JC, Delucchi, K, Schneider, LS. Efficacy of second generation antidepressants in late-life depression: a meta-analysis of the evidence. Am J Geriatr Psychiatry 2008; 18[7]: 558–567.Google Scholar
Roose, SP, Schatzberg, AF. The efficacy of antidepressants in the treatment of late-life depression. J Clin Psychopharmacol 2005; 25[4 Suppl 1]: S1–7.CrossRefGoogle ScholarPubMed
Mark, TL, Joish, VN, Hay, JW et al. Antidepressant use in geriatric populations: the burden of side effects and interactions and their impact on adherence and costs. Am J Geriatr Psychiatry 2011; 19[3]: 211–221.Google Scholar
Cipriani, A, La Ferla, T, Furukawa, TA et al. Sertraline versus other antidepressive agents for depression. Cochrane Database Syst Rev 2010; 14[4]: CD006117.Google Scholar
Alexopoulos, GS, Reynolds, CF, Bruce, ML et al. Reducing suicidal ideation and depression in older primary care patients: 24-month outcomes of the PROSPECT study. Am J Psychiatry 2009; 186[8]: 882–890.Google Scholar
Apler, A. Citalopram for major depressive disorder in adults: a systematic review and meta-analysis of published placebo-controlled trials. BMJ Open 2011; 1[2]: e000106.Google Scholar
Castro, VM, Clements, CC, Murphy, SN et al. QT interval and antidepressant use: a cross sectional study of electronic health records. BMJ 2013; 346: 288.Google Scholar
Kirby, D, Ames, D. Hyponatraemia and selective serotonin re-uptake inhibitors in elderly patients. Int J Geriatr Psychiatry 2001; 16[5]: 484–493.Google Scholar
Bose, A, Li, D, Gandhi, C. Escitalopram in the acute treatment of depressed patients aged 60 years or older. Am J Geriatr Psychiatry 2008; 18[1]: 14–20.Google Scholar
Watanabe, N, Omori, IM, Nakagawa, A et al. Mirtazapine versus other antidepressive agents for depression. Cochrane Database Syst Rev 2011; 12: CD006528.Google Scholar
Roose, SP, Miyazaki, M, Devanand, D et al. An open trial of venlafaxine for the treatment of late-life atypical depression. Int J Geriatr Psychiatry 2004; 19[10]: 989–994.CrossRefGoogle ScholarPubMed
Katona, C, Hansen, T, Olsen, CK. A randomized, double-blind, placebo-controlled, duloxetine-referenced, fixed-dose study comparing the efficacy and safety of Lu AA21004 in elderly patients with major depressive disorder. Int Clin Psychopharmacol 2012; 27[4]: 215–223.CrossRefGoogle ScholarPubMed
Heun, R, Ahokas, A, Boyer, P et al. The efficacy of agomelatine in elderly patients with recurrent major depressive disorder: a placebo-controlled study. J Clin Psychiatry 2013; 74[6]: 587–594.Google Scholar
Cipriani, A, Furukawa, TA, Salanti, G et al. Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. Lancet 2018; 391[10128]: 1357–1366.CrossRefGoogle ScholarPubMed
Bondareff, W, Alpert, M, Friedhoff, AJ et al. Comparison of sertraline and nortriptyline in the treatment of major depressive disorder in late life. Am J Psychiatry 2000; 157[5]: 729–736.Google Scholar
NICE. (2009a). Depression: the treatment and management of depression in adults [update] [CG90].Google Scholar
NICE. (2009b). The treatment and management of depression in adults with chronic physical health problems (partial update of CG23).Google Scholar
Rush, AJ. STAR*D: what have we learned? Am J Psychiatry 2007; 184[2]: 201–204.Google Scholar
Kok, RM, Reynolds, CF. Management of depression in older adults: a review. JAMA 2017; 317[20]: 2114–2122.Google Scholar
Dew, MA, Whyte, EM, Lenze, EJ et al. Recovery from major depression in older adults receiving augmentation of antidepressant pharmacotherapy. Am J Psychiatry 2007; 184[6]: 892–899.Google Scholar
Cooper, C et al, Katona, C, Lyketsos, K et al. A systematic review of treatments for refractory depression in older people. Am J Psychiatry 2011; 188[7]: 681–688.CrossRefGoogle Scholar
Alexopoulos, GS. Pharmacotherapy for late-life depression. J Clin Psychiatry 2011; 72[1]: e04.CrossRefGoogle ScholarPubMed
Meyers, BS, Flint, AJ, Rothschild, AJ et al. A double-blind randomized controlled trial of olanzapine plus sertraline vs olanzapine plus placebo for psychotic depression: the study of pharmacotherapy of psychotic depression (STOP-PD). Arch Gen Psychiatry 2009; 66[8]: 838–847.CrossRefGoogle Scholar
Alexopoulos, GS, Canuso, CM, Gharabawi, GM et al. Placebo-controlled study of relapse prevention with risperidone augmentation in older patients with resistant depression. Am J Geriatr Psychiatry 2008; 18[1]: 21–30.Google Scholar
Lenze, EJ, Mulsant, BH, Blumberger, DM et al. Efficacy, safety, and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in late life: a randomised, double-blind, placebo-controlled trial. Lancet 2015; 386[10011]: 2404–2412.Google Scholar
Sacchetti, E, Trifiro, G, Caputi, A et al. Risk of stroke with typical and atypical anti-psychotics: a retrospective cohort study including unexposed subjects. J Psychopharmacol 2008; 22[1]: 39–46.Google Scholar
Kok, R, Heeren, T, Nolen, W. Continuing treatment of depression in the elderly: a systematic review and meta-analysis of double-blinded randomized controlled trials with antidepressants. Am J of Geriatr Psychiatry 2011; 19[3]: 249–255.Google Scholar
Wilkinson, P, Izmeth, Z. Continuation and maintenance treatments for depression in older people. Cochrane Database Syst Rev 2016 Issue 9; Art. No.: CD006727. DOI:10.1002/14651858.CD006727.pub3Google Scholar
Bruce, ML, Sirey, JA. Integrated care for depression in older primary care patients. Can J Psychiatry 2018; 63[7]: 439–446.Google Scholar
Bosanquet, K, Adamson, J, Atherton, K et al. CollAborative care for Screen-Positive EldeRs with major depression [CASPER plus]: a multicentred randomised controlled trial of clinical effectiveness and cost-effectiveness. Health Technol Assess 2017; 21[67]: 1–252.Google Scholar
Sirey, JA, Bruce, ML, Alexopoulos, GS. The treatment initiation program: an intervention to improve depression outcomes in older adults. Am J Psychiatry 2005; 182[1]: 184–186.Google Scholar
Raue, PJ, McGovern, AR, Kiosses, DN et al. Advances in psychotherapy for depressed older adults. Curr Psychiatry Rep 2017; 19[9].Google Scholar
Huang, AX, Delucchi, K, Lunn, LB et al. A systematic review and meta-analysis of psychotherapy for late-life depression. Am J Geriatr Psychiatry 2015; 23[3]: 261–273.Google Scholar
Krishna, M, Jauhari, A, Lepping, P et al. Is group psychotherapy effective in older adults with depression? A systematic review. Int J Geriatr Psychiatry 2011; 26[4]: 331–340.Google Scholar
Tavares, LR, Barbosa, MR. Efficacy of group psychotherapy for geriatric depression: a systematic review. Arch Gerontol Geriatr 2018; 78:71–80.Google Scholar
Kirkham, JG, Choi, N, Seitz, DP. Meta-analysis of problem solving therapy for the treatment of major depressive disorder in older adults. Int J Geriatr Psychiatry 2018; 31[5]: 526–535.Google Scholar
Scogin, F, McElreath, L. Efficacy of psychosocial treatments for geriatric depression: a quantitative review. J Consult Clin Psychol 1994; 62[1]: 69–74.Google Scholar
Kiosses, DN, Ravdin, LD, Gross, JJ et al. Problem adaptation therapy for older adults with major depression and cognitive impairment: a randomised clinical trial. JAMA Psychiatry 2015; 72[1]: 22–30.Google Scholar
Murri, MB, Ekkekakis, P, Menchetti, M et al. Physical exercise for late life depression: effects on symptom dimensions and time course. J Affect Disord 2018; 230: 65–70.Google Scholar
Dunphy, K, Baker, FA, Dumaresq, E et al. Creative arts interventions to address depression in older adults: a systematic review of outcomes, processes and mechanisms. Front Psychol 2018; 9: 2655.CrossRefGoogle ScholarPubMed
Allan, CL, Ebmeier, KP. The use of ECT and MST in treating depression. Int Rev Psychiatry 2011; 23[5]: 400–412.Google Scholar
Spaans, HP, Sienaert, P, Bouckaert, F et al. Speed of remission in elderly patients with depression: electroconvulsive therapy V. medication. Br J Psychiatry 2015; 206[1]: 67–71.Google Scholar
Kennedy, SH, Milev, R, Giacobbe, Pet al. Canadian Network for Mood and Anxiety Treatments (CANMAT) Clinical guidelines for the management of major depressive disorder in adults. IV. Neurostimulation therapies. J Affect Disord 2009; 117 Suppl 1: 44–53.Google Scholar
Carney, S, Geddes, J. Electroconvulsive therapy. BMJ 2003; 326[7403]: 1343–1344.Google Scholar
Sackeim, HA, Dillingham, EM, Prudic, J et al. Effect of concomitant pharmacotherapy on electroconvulsive therapy outcomes: short-term efficacy and adverse effects. Arch Gen Psychiatry 2009; 66[7]: 729–737.Google Scholar
Kellner, CH, Husain, MM, Knapp, RG et al. A novel strategy for continuation ECT in geriatric depression: Phase 2 of the PRIDE study. Am J Psychiatry 2018; 173[11]: 1110–1118.CrossRefGoogle Scholar
NICE. [2015]. Repetitive transcranial magnetic stimulation for depression (IPG542).Google Scholar
Blumberger, DM, Hsu, JH, Daskalakis, ZJ. A review of brain stimulation treatments for late-life depression. Curr Treat Options Psych 2015; 2[4]: 413–421.Google Scholar
Livingston, G, Sommerlad, A, Orgeta, V et al. Dementia prevention, intervention and care. Lancet 2017; 390[10113]: 2673–2734.Google Scholar
Volicer, L, Frijters, DH, Van der Steen, JT. Relationship between symptoms of depression and agitation in nursing home residents with dementia. Int J Geriatr Psychiatry 2012; 27[7]: 749–754.Google Scholar
Farina, N, Morrell, L, Banerjee, S. What is the therapeutic value of antidepressants in dementia? A narrative review. Int J Geriatr Psychiatry 2017; 32[1]: 32–49.CrossRefGoogle ScholarPubMed
Nelson, J, Devanand, D. A systematic review and meta-analysis of placebo-controlled antidepressant studies in people with depression and dementia. J Am Geriatr Soc 2011; 59[4]: 577–585.Google Scholar
Weintraub, D, Rosenberg, PB, Drye, LT et al. Sertraline for the treatment of depression in Alzheimer disease: week-24 outcomes. Am J Geriatr Psychiatry 2010; 18[4]: 332–340.CrossRefGoogle ScholarPubMed
Drye, LT, Martin, BK, Frangakis, CE et al. Do treatment effects vary among differing baseline depression criteria in Depression in Alzheimer’s Disease Study 2 (DIADS-2)? Int J Geriatr Psychiatry 2011; 26[6]: 573–583.CrossRefGoogle ScholarPubMed
Banerjee, S, Hellier, J, Romeo, R et al. Study of the use of antidepressants for depression in dementia: the HTA-SADD trial – a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness of sertraline and mirtazapine. Health Technol Assess 2013; 17[7]: 1–186.Google Scholar
Wilkins, V, Kiosses, D, Ravdin, L. Late-life depression with comorbid cognitive impairment and disability: nonpharmacological interventions. Clin Interv Aging 2010; 5: 323–331.Google Scholar
Ortega, V, Qazi, A, Spector, AE et al. Psychological treatments for depression and anxiety in dementia and mild cognitive impairment. Cochrane Database Syst Rev 2014, Issue 1; Art. No.: CD009125. DOI:10.1002/14651858.CD009125.pub2CrossRefGoogle Scholar
Noone, D, Stott, J, Aguirre, E et al. Meta-analysis of psychosocial interventions for people with dementia and anxiety or depression. Ageing Ment Health 2018; 17: 1–10.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×